Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms

The glial environment is an important determinant of neuronal health in experimental models of neurodegeneration. Specifically, astrocytes have been shown, dependent on context, to be both injurious and protective. Human pluripotent stem cells offer a powerful new system to improve our understanding...

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Veröffentlicht in:	Cell death and differentiation 2012-05, Vol.19 (5), p.779-787
Hauptverfasser:	Gupta, K, Patani, R, Baxter, P, Serio, A, Story, D, Tsujita, T, Hayes, J D, Pedersen, R A, Hardingham, G E, Chandran, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyotrophic lateral sclerosis Animals Antioxidants Apoptosis Astrocytes Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Biochemistry Biology Biomedical and Life Sciences Catalytic subunits Cell Biology Cell Cycle Analysis Cell death Cell Line Cell Survival - drug effects Cells, Cultured Disease Embryo cells Embryonic Stem Cells - cytology Glutamate-cysteine ligase Glutamate-Cysteine Ligase - metabolism Glutathione Glutathione - metabolism Humans Hydrogen peroxide Hydrogen Peroxide - pharmacology Immunohistochemistry Life Sciences Mice Mice, Mutant Strains Neural Stem Cells - cytology Neural Stem Cells - drug effects Neural Stem Cells - metabolism Neurodegeneration Neuronal-glial interactions Neurons Neuroprotection NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oleanolic Acid - analogs & derivatives Oleanolic Acid - pharmacology Original Paper Oxidative stress Parkinson's disease Physiology Regenerative medicine Smad protein Stem Cells Transcription factors triterpenoids
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