Demonstration of intrahepatic accumulated microbubble on ultrasound represents the grade of hepatic fibrosis
Objectives To examine the feasibility of perflubutane-based ultrasound for grading hepatic fibrosis. Methods This prospective study included 202 subjects; main study (controls:33, F0–1:35, F2:26, F3:23, cirrhosis:29) and subsequent study (controls:16, F0–1:7, F2:20, F3:7, cirrhosis:6). Diagnostic ab...
Gespeichert in:
| Veröffentlicht in: | European radiology 2012-05, Vol.22 (5), p.1083-1090 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1090 |
|---|---|
| container_issue | 5 |
| container_start_page | 1083 |
| container_title | European radiology |
| container_volume | 22 |
| creator | Ishibashi, Hiroyuki Maruyama, Hitoshi Takahashi, Masanori Shimada, Taro Kamesaki, Hidehiro Fujiwara, Keiichi Imazeki, Fumio Yokosuka, Osamu |
| description | Objectives
To examine the feasibility of perflubutane-based ultrasound for grading hepatic fibrosis.
Methods
This prospective study included 202 subjects; main study (controls:33, F0–1:35, F2:26, F3:23, cirrhosis:29) and subsequent study (controls:16, F0–1:7, F2:20, F3:7, cirrhosis:6). Diagnostic abilities for assessing fibrosis grade were compared between contrast findings and FIB4 (age × AST/[platelet count × ALT
0.5
]).
Results
High-power emission produced an intrahepatic band-like structure, and the three-layer appearance was less frequent and monolayer appearance was more frequent in cirrhosis than controls/chronic hepatitis (
P
|
| doi_str_mv | 10.1007/s00330-011-2346-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3321145</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2627892841</sourcerecordid><originalsourceid>FETCH-LOGICAL-c567t-446d9f47df0921819e58fb1d5d10dd970006afa7e5a70e1a058b97d9ef36a663</originalsourceid><addsrcrecordid>eNp1kUtv1TAQhS0EoreFH8AGRazYBGZsJ443SKg8pUpsureceHxvqsS-2AlS_30d3bY8JFaWPZ_PzJnD2CuEdwig3mcAIaAGxJoL2dbNE7ZDKXiN0MmnbAdadLXSWp6x85xvAECjVM_ZGeccFG-7HZs-0RxDXpJdxhiq6KsxlMuBjuVhqOwwrPM62YVcNY9Div3a9xNVBV2nwuW4BlclOibKFJZcLQeq9sk62qQeVPzYp5jH_II983bK9PL-vGDXXz5fX36rr358_X758aoemlYttZSt014q50Fz7FBT0_keXeMQnNOq-Gitt4oaq4DQQtP1WjlNXrS2bcUF-3CSPa79TG6gzdFkjmmcbbo10Y7m70oYD2YffxkhOKJsisDbe4EUf66UFzOPeaBpsoHimg0KLrqyYqkK-uYf9CauKRR3RitEjSC6AuEJKgvMOZF_nAXBbEmaU5KmJGm2JM02w-s_TTz-eIiuAPwE5FIKe0q_O_9f9Q6ogqvb</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>971191038</pqid></control><display><type>article</type><title>Demonstration of intrahepatic accumulated microbubble on ultrasound represents the grade of hepatic fibrosis</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Ishibashi, Hiroyuki ; Maruyama, Hitoshi ; Takahashi, Masanori ; Shimada, Taro ; Kamesaki, Hidehiro ; Fujiwara, Keiichi ; Imazeki, Fumio ; Yokosuka, Osamu</creator><creatorcontrib>Ishibashi, Hiroyuki ; Maruyama, Hitoshi ; Takahashi, Masanori ; Shimada, Taro ; Kamesaki, Hidehiro ; Fujiwara, Keiichi ; Imazeki, Fumio ; Yokosuka, Osamu</creatorcontrib><description>Objectives
To examine the feasibility of perflubutane-based ultrasound for grading hepatic fibrosis.
Methods
This prospective study included 202 subjects; main study (controls:33, F0–1:35, F2:26, F3:23, cirrhosis:29) and subsequent study (controls:16, F0–1:7, F2:20, F3:7, cirrhosis:6). Diagnostic abilities for assessing fibrosis grade were compared between contrast findings and FIB4 (age × AST/[platelet count × ALT
0.5
]).
Results
High-power emission produced an intrahepatic band-like structure, and the three-layer appearance was less frequent and monolayer appearance was more frequent in cirrhosis than controls/chronic hepatitis (
P
< 0.0001). Intensity difference at 15-min phase showed most significant correlation with fibrosis grade (
ρ
= 0.79,
P
< 0.0001), and the best areas under the receiver operating characteristic curves are 0.88 for marked fibrosis, 0.95 for advanced fibrosis and 0.97 for cirrhosis, which were significantly higher than those of FIB4, 0.85 for marked fibrosis, 0.89 for advanced fibrosis and 0.90 for cirrhosis. Sensitivity, specificity and efficiency of the intensity difference were 88%, 72% and 81% for marked fibrosis, 85%, 91% and 89% for advanced fibrosis and 97%, 90% and 91% for cirrhosis, respectively. The subsequent study validated the main study results; significant correlation between the intensity difference and the fibrosis grade (
ρ
= 0.73–0.77,
P
< 0.0001).
Conclusions
Perflubutane-based ultrasound accurately predicts the grade of hepatic fibrosis.
Key Points
•
The behaviour of intrahepatic microbubbles depends on the severity of hepatic fibrosis
.
•
Layer enhancement pattern simply represents the degree of chronic liver disease
.
•
Parenchymal intensity change due to high-power emission predicts the hepatic fibrosis grade
.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-011-2346-5</identifier><identifier>PMID: 22207268</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Age ; Aged ; Biopsy ; Cirrhosis ; Contrast Media - pharmacokinetics ; Diagnostic Radiology ; Feasibility Studies ; Female ; Ferric Compounds - pharmacokinetics ; Fibrosis ; Fluorocarbons - pharmacokinetics ; Hepatitis ; Hepatobiliary-Pancreas ; Humans ; Image Interpretation, Computer-Assisted - methods ; Imaging ; Internal Medicine ; Interventional Radiology ; Iron - pharmacokinetics ; Liver cirrhosis ; Liver Cirrhosis - diagnostic imaging ; Liver diseases ; Medicine ; Medicine & Public Health ; Microbubbles ; Middle Aged ; Neuroradiology ; Oxides - pharmacokinetics ; Platelets ; Radiology ; Reproducibility of Results ; Sensitivity and Specificity ; Severity of Illness Index ; Ultrasonic imaging ; Ultrasonography - methods ; Ultrasound ; Young Adult</subject><ispartof>European radiology, 2012-05, Vol.22 (5), p.1083-1090</ispartof><rights>The Author(s) 2011</rights><rights>European Society of Radiology 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-446d9f47df0921819e58fb1d5d10dd970006afa7e5a70e1a058b97d9ef36a663</citedby><cites>FETCH-LOGICAL-c567t-446d9f47df0921819e58fb1d5d10dd970006afa7e5a70e1a058b97d9ef36a663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-011-2346-5$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-011-2346-5$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22207268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishibashi, Hiroyuki</creatorcontrib><creatorcontrib>Maruyama, Hitoshi</creatorcontrib><creatorcontrib>Takahashi, Masanori</creatorcontrib><creatorcontrib>Shimada, Taro</creatorcontrib><creatorcontrib>Kamesaki, Hidehiro</creatorcontrib><creatorcontrib>Fujiwara, Keiichi</creatorcontrib><creatorcontrib>Imazeki, Fumio</creatorcontrib><creatorcontrib>Yokosuka, Osamu</creatorcontrib><title>Demonstration of intrahepatic accumulated microbubble on ultrasound represents the grade of hepatic fibrosis</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To examine the feasibility of perflubutane-based ultrasound for grading hepatic fibrosis.
Methods
This prospective study included 202 subjects; main study (controls:33, F0–1:35, F2:26, F3:23, cirrhosis:29) and subsequent study (controls:16, F0–1:7, F2:20, F3:7, cirrhosis:6). Diagnostic abilities for assessing fibrosis grade were compared between contrast findings and FIB4 (age × AST/[platelet count × ALT
0.5
]).
Results
High-power emission produced an intrahepatic band-like structure, and the three-layer appearance was less frequent and monolayer appearance was more frequent in cirrhosis than controls/chronic hepatitis (
P
< 0.0001). Intensity difference at 15-min phase showed most significant correlation with fibrosis grade (
ρ
= 0.79,
P
< 0.0001), and the best areas under the receiver operating characteristic curves are 0.88 for marked fibrosis, 0.95 for advanced fibrosis and 0.97 for cirrhosis, which were significantly higher than those of FIB4, 0.85 for marked fibrosis, 0.89 for advanced fibrosis and 0.90 for cirrhosis. Sensitivity, specificity and efficiency of the intensity difference were 88%, 72% and 81% for marked fibrosis, 85%, 91% and 89% for advanced fibrosis and 97%, 90% and 91% for cirrhosis, respectively. The subsequent study validated the main study results; significant correlation between the intensity difference and the fibrosis grade (
ρ
= 0.73–0.77,
P
< 0.0001).
Conclusions
Perflubutane-based ultrasound accurately predicts the grade of hepatic fibrosis.
Key Points
•
The behaviour of intrahepatic microbubbles depends on the severity of hepatic fibrosis
.
•
Layer enhancement pattern simply represents the degree of chronic liver disease
.
•
Parenchymal intensity change due to high-power emission predicts the hepatic fibrosis grade
.</description><subject>Age</subject><subject>Aged</subject><subject>Biopsy</subject><subject>Cirrhosis</subject><subject>Contrast Media - pharmacokinetics</subject><subject>Diagnostic Radiology</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Ferric Compounds - pharmacokinetics</subject><subject>Fibrosis</subject><subject>Fluorocarbons - pharmacokinetics</subject><subject>Hepatitis</subject><subject>Hepatobiliary-Pancreas</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Iron - pharmacokinetics</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - diagnostic imaging</subject><subject>Liver diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microbubbles</subject><subject>Middle Aged</subject><subject>Neuroradiology</subject><subject>Oxides - pharmacokinetics</subject><subject>Platelets</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography - methods</subject><subject>Ultrasound</subject><subject>Young Adult</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUtv1TAQhS0EoreFH8AGRazYBGZsJ443SKg8pUpsureceHxvqsS-2AlS_30d3bY8JFaWPZ_PzJnD2CuEdwig3mcAIaAGxJoL2dbNE7ZDKXiN0MmnbAdadLXSWp6x85xvAECjVM_ZGeccFG-7HZs-0RxDXpJdxhiq6KsxlMuBjuVhqOwwrPM62YVcNY9Div3a9xNVBV2nwuW4BlclOibKFJZcLQeq9sk62qQeVPzYp5jH_II983bK9PL-vGDXXz5fX36rr358_X758aoemlYttZSt014q50Fz7FBT0_keXeMQnNOq-Gitt4oaq4DQQtP1WjlNXrS2bcUF-3CSPa79TG6gzdFkjmmcbbo10Y7m70oYD2YffxkhOKJsisDbe4EUf66UFzOPeaBpsoHimg0KLrqyYqkK-uYf9CauKRR3RitEjSC6AuEJKgvMOZF_nAXBbEmaU5KmJGm2JM02w-s_TTz-eIiuAPwE5FIKe0q_O_9f9Q6ogqvb</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Ishibashi, Hiroyuki</creator><creator>Maruyama, Hitoshi</creator><creator>Takahashi, Masanori</creator><creator>Shimada, Taro</creator><creator>Kamesaki, Hidehiro</creator><creator>Fujiwara, Keiichi</creator><creator>Imazeki, Fumio</creator><creator>Yokosuka, Osamu</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20120501</creationdate><title>Demonstration of intrahepatic accumulated microbubble on ultrasound represents the grade of hepatic fibrosis</title><author>Ishibashi, Hiroyuki ; Maruyama, Hitoshi ; Takahashi, Masanori ; Shimada, Taro ; Kamesaki, Hidehiro ; Fujiwara, Keiichi ; Imazeki, Fumio ; Yokosuka, Osamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-446d9f47df0921819e58fb1d5d10dd970006afa7e5a70e1a058b97d9ef36a663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age</topic><topic>Aged</topic><topic>Biopsy</topic><topic>Cirrhosis</topic><topic>Contrast Media - pharmacokinetics</topic><topic>Diagnostic Radiology</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Ferric Compounds - pharmacokinetics</topic><topic>Fibrosis</topic><topic>Fluorocarbons - pharmacokinetics</topic><topic>Hepatitis</topic><topic>Hepatobiliary-Pancreas</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Iron - pharmacokinetics</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - diagnostic imaging</topic><topic>Liver diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microbubbles</topic><topic>Middle Aged</topic><topic>Neuroradiology</topic><topic>Oxides - pharmacokinetics</topic><topic>Platelets</topic><topic>Radiology</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography - methods</topic><topic>Ultrasound</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishibashi, Hiroyuki</creatorcontrib><creatorcontrib>Maruyama, Hitoshi</creatorcontrib><creatorcontrib>Takahashi, Masanori</creatorcontrib><creatorcontrib>Shimada, Taro</creatorcontrib><creatorcontrib>Kamesaki, Hidehiro</creatorcontrib><creatorcontrib>Fujiwara, Keiichi</creatorcontrib><creatorcontrib>Imazeki, Fumio</creatorcontrib><creatorcontrib>Yokosuka, Osamu</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishibashi, Hiroyuki</au><au>Maruyama, Hitoshi</au><au>Takahashi, Masanori</au><au>Shimada, Taro</au><au>Kamesaki, Hidehiro</au><au>Fujiwara, Keiichi</au><au>Imazeki, Fumio</au><au>Yokosuka, Osamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Demonstration of intrahepatic accumulated microbubble on ultrasound represents the grade of hepatic fibrosis</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>22</volume><issue>5</issue><spage>1083</spage><epage>1090</epage><pages>1083-1090</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
To examine the feasibility of perflubutane-based ultrasound for grading hepatic fibrosis.
Methods
This prospective study included 202 subjects; main study (controls:33, F0–1:35, F2:26, F3:23, cirrhosis:29) and subsequent study (controls:16, F0–1:7, F2:20, F3:7, cirrhosis:6). Diagnostic abilities for assessing fibrosis grade were compared between contrast findings and FIB4 (age × AST/[platelet count × ALT
0.5
]).
Results
High-power emission produced an intrahepatic band-like structure, and the three-layer appearance was less frequent and monolayer appearance was more frequent in cirrhosis than controls/chronic hepatitis (
P
< 0.0001). Intensity difference at 15-min phase showed most significant correlation with fibrosis grade (
ρ
= 0.79,
P
< 0.0001), and the best areas under the receiver operating characteristic curves are 0.88 for marked fibrosis, 0.95 for advanced fibrosis and 0.97 for cirrhosis, which were significantly higher than those of FIB4, 0.85 for marked fibrosis, 0.89 for advanced fibrosis and 0.90 for cirrhosis. Sensitivity, specificity and efficiency of the intensity difference were 88%, 72% and 81% for marked fibrosis, 85%, 91% and 89% for advanced fibrosis and 97%, 90% and 91% for cirrhosis, respectively. The subsequent study validated the main study results; significant correlation between the intensity difference and the fibrosis grade (
ρ
= 0.73–0.77,
P
< 0.0001).
Conclusions
Perflubutane-based ultrasound accurately predicts the grade of hepatic fibrosis.
Key Points
•
The behaviour of intrahepatic microbubbles depends on the severity of hepatic fibrosis
.
•
Layer enhancement pattern simply represents the degree of chronic liver disease
.
•
Parenchymal intensity change due to high-power emission predicts the hepatic fibrosis grade
.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22207268</pmid><doi>10.1007/s00330-011-2346-5</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2012-05, Vol.22 (5), p.1083-1090 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3321145 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Age Aged Biopsy Cirrhosis Contrast Media - pharmacokinetics Diagnostic Radiology Feasibility Studies Female Ferric Compounds - pharmacokinetics Fibrosis Fluorocarbons - pharmacokinetics Hepatitis Hepatobiliary-Pancreas Humans Image Interpretation, Computer-Assisted - methods Imaging Internal Medicine Interventional Radiology Iron - pharmacokinetics Liver cirrhosis Liver Cirrhosis - diagnostic imaging Liver diseases Medicine Medicine & Public Health Microbubbles Middle Aged Neuroradiology Oxides - pharmacokinetics Platelets Radiology Reproducibility of Results Sensitivity and Specificity Severity of Illness Index Ultrasonic imaging Ultrasonography - methods Ultrasound Young Adult |
| title | Demonstration of intrahepatic accumulated microbubble on ultrasound represents the grade of hepatic fibrosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T10%3A19%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Demonstration%20of%20intrahepatic%20accumulated%20microbubble%20on%20ultrasound%20represents%20the%20grade%20of%20hepatic%20fibrosis&rft.jtitle=European%20radiology&rft.au=Ishibashi,%20Hiroyuki&rft.date=2012-05-01&rft.volume=22&rft.issue=5&rft.spage=1083&rft.epage=1090&rft.pages=1083-1090&rft.issn=0938-7994&rft.eissn=1432-1084&rft_id=info:doi/10.1007/s00330-011-2346-5&rft_dat=%3Cproquest_pubme%3E2627892841%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=971191038&rft_id=info:pmid/22207268&rfr_iscdi=true |