Effect of Carcinogenic Acrolein on DNA Repair and Mutagenic Susceptibility

Acrolein (Acr), a ubiquitous environmental contaminant, is a human carcinogen. Acr can react with DNA to form mutagenic α- and γ-hydroxy-1, N2-cyclic propano-2′-deoxyguanosine adducts (α-OH-Acr-dG and γ-OH-Acr-dG). We demonstrate here that Acr-dG adducts can be efficiently repaired by the nucleotide...

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Veröffentlicht in:	The Journal of biological chemistry 2012-04, Vol.287 (15), p.12379-12386
Hauptverfasser:	Wang, Hsiang-Tsui, Hu, Yu, Tong, Dan, Huang, Jian, Gu, Liya, Wu, Xue-Ru, Chung, Fung-Lung, Li, Guo-Min, Tang, Moon-shong
Format:	Artikel
Sprache:	eng
Schlagworte:	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - chemistry Acrolein Acrolein - pharmacology Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Base Sequence BPDE-DNA Damage Bronchioles - cytology Carcinogens - pharmacology Cells, Cultured DNA Adducts - metabolism DNA and Chromosomes DNA Damage DNA Glycosylases - genetics DNA Glycosylases - metabolism DNA Mismatch Repair DNA Nucleotide Excision Repair DNA Repair DNA Repair - drug effects DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epithelial Cells - drug effects Epithelial Cells - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression - drug effects Humans Lung - cytology Lung Cancer Mismatch Repair Endonuclease PMS2 Mutagenesis Mutagens - chemistry Mutagens - pharmacology MutL Protein Homolog 1 Nuclear Proteins - genetics Nuclear Proteins - metabolism Oxidation-Reduction Plasmids - chemistry Plasmids - radiation effects Respiratory Mucosa - cytology Ultraviolet Rays Xeroderma Pigmentosum Group A Protein - genetics Xeroderma Pigmentosum Group A Protein - metabolism
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