The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

The endocannabinoid 2‐arachidonoylglycerol (2‐AG) is a lipid mediator involved in various physiological processes. In response to neural activity, 2‐AG is synthesized post‐synaptically, then activates pre‐synaptic cannabinoid CB1 receptors (CB1Rs) in a retrograde manner, resulting in transient and l...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta Physiologica 2012-02, Vol.204 (2), p.267-276
Hauptverfasser:	Savinainen, J. R., Saario, S. M., Laitinen, J. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-AG hydrolase ABHD12 ABHD6 Animals Arachidonic Acids - metabolism Biological and medical sciences Cannabinoid Receptor Antagonists Cannabinoid Receptor Modulators - metabolism endocannabinoid Endocannabinoids Fundamental and applied biological sciences. Psychology Glycerides - metabolism Humans Mice Microglia - metabolism monoacylglycerol lipase Monoacylglycerol Lipases - metabolism Monoacylglycerol Lipases - physiology Neurons - metabolism Receptors, Cannabinoid - metabolism Reviews Signal Transduction - physiology Synaptic Transmission - physiology Vertebrates: anatomy and physiology, studies on body, several organs or systems α/β-hydrolase domain
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!