Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer

DNA amplifications, leading to the overexpression of oncogenes, are a cardinal feature of lung cancer and directly contribute to its pathogenesis. To uncover such novel alterations, we performed an array-based comparative genomic hybridization survey of 128 non-small-cell lung cancer cell lines and...

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Veröffentlicht in:	Oncogene 2010-03, Vol.29 (10), p.1421-1430
Hauptverfasser:	Kim, Y H, Kwei, K A, Girard, L, Salari, K, Kao, J, Pacyna-Gengelbach, M, Wang, P, Hernandez-Boussard, T, Gazdar, A F, Petersen, I, Minna, J D, Pollack, J R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Adaptor proteins Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adaptor Proteins, Signal Transducing - physiology Apoptosis BCR-ABL protein Biological and medical sciences Blotting, Western Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - physiopathology Cell Biology Cell growth Cell Line, Tumor Cell Movement Cell physiology Cell Proliferation Cell Survival Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome 22 Chromosomes, Human, Pair 22 - genetics Chronic myeloid leukemia Comparative Genomic Hybridization Epithelial cells Fundamental and applied biological sciences. Psychology Fusion protein Gene Amplification Gene expression Gene Expression Profiling Genetic aspects Genomics Human Genetics Humans Hybridization In Situ Hybridization, Fluorescence Internal Medicine Kinases Lung cancer Lung cancer, Non-small cell Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - physiopathology Medical sciences Medicine Medicine & Public Health Molecular and cellular biology Myeloid leukemia Non-small cell lung carcinoma Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear Proteins - physiology Oligonucleotide Array Sequence Analysis Oncogenes Oncology original-article Phenotypes Physiological aspects Pneumology Proteins RNA Interference RNA-mediated interference Signal transduction Transcription Tumor cell lines Tumorigenesis Tumors Tumors of the respiratory system and mediastinum
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