Progesterone impairs social recognition in male rats
The influence of progesterone in the brain and on the behavior of females is fairly well understood. However, less is known about the effect of progesterone in the male system. In male rats, receptors for progesterone are present in virtually all vasopressin (AVP) immunoreactive cells in the bed nuc...
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| Veröffentlicht in: | Hormones and behavior 2012-04, Vol.61 (4), p.598-604 |
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| description | The influence of progesterone in the brain and on the behavior of females is fairly well understood. However, less is known about the effect of progesterone in the male system. In male rats, receptors for progesterone are present in virtually all vasopressin (AVP) immunoreactive cells in the bed nucleus of the stria terminalis (BST) and the medial amygdala (MeA). This colocalization functions to regulate AVP expression, as progesterone and/or progestin receptors (PR)s suppress AVP expression in these same extrahypothalamic regions in the brain. These data suggest that progesterone may influence AVP-dependent behavior. While AVP is implicated in numerous behavioral and physiological functions in rodents, AVP appears essential for social recognition of conspecifics. Therefore, we examined the effects of progesterone on social recognition. We report that progesterone plays an important role in modulating social recognition in the male brain, as progesterone treatment leads to a significant impairment of social recognition in male rats. Moreover, progesterone appears to act on PRs to impair social recognition, as progesterone impairment of social recognition is blocked by a PR antagonist, RU-486. Social recognition is also impaired by a specific progestin agonist, R5020. Interestingly, we show that progesterone does not interfere with either general memory or olfactory processes, suggesting that progesterone seems critically important to social recognition memory. These data provide strong evidence that physiological levels of progesterone can have an important impact on social behavior in male rats.
► We report that progesterone is important in modulating social recognition in the male brain. ► Progesterone treatment leads to a significant impairment in social recognition in male rats. ► Progesterone impairment of social recognition is blocked by a PR antagonist, RU-486. ► Social recognition is also impaired by the synthetic progestin, R5020. ► Progesterone did not interfere with either general memory or olfactory processes. |
| doi_str_mv | 10.1016/j.yhbeh.2012.02.009 |
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► We report that progesterone is important in modulating social recognition in the male brain. ► Progesterone treatment leads to a significant impairment in social recognition in male rats. ► Progesterone impairment of social recognition is blocked by a PR antagonist, RU-486. ► Social recognition is also impaired by the synthetic progestin, R5020. ► Progesterone did not interfere with either general memory or olfactory processes.</description><identifier>ISSN: 0018-506X</identifier><identifier>EISSN: 1095-6867</identifier><identifier>DOI: 10.1016/j.yhbeh.2012.02.009</identifier><identifier>PMID: 22366506</identifier><identifier>CODEN: HOBEAO</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Amygdala - physiology ; Animal behavior ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Discrimination (Psychology) - drug effects ; Feeding Behavior - drug effects ; Fundamental and applied biological sciences. Psychology ; Hormone Antagonists - pharmacology ; Hormones and behavior ; Male ; Males ; Mifepristone - pharmacology ; Progesterone ; Progesterone - toxicity ; Progesterone Congeners - pharmacology ; Progestin receptors ; Promegestone - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychomotor Performance - physiology ; Rats ; Rats, Sprague-Dawley ; Recognition (Psychology) - drug effects ; Rodents ; Septal Nuclei - physiology ; Smell - drug effects ; Social Behavior ; Social memory ; Social recognition behavior ; Vasopressin ; Vasopressins - physiology</subject><ispartof>Hormones and behavior, 2012-04, Vol.61 (4), p.598-604</ispartof><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><rights>2012 Elsevier Inc. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-e18e13cb3573e391421d7088fa4b3fe9ceafe18d960141f8be4d0e5f601ea933</citedby><cites>FETCH-LOGICAL-c515t-e18e13cb3573e391421d7088fa4b3fe9ceafe18d960141f8be4d0e5f601ea933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.yhbeh.2012.02.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,778,782,883,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25812065$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22366506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bychowski, Meaghan E.</creatorcontrib><creatorcontrib>Auger, Catherine J.</creatorcontrib><title>Progesterone impairs social recognition in male rats</title><title>Hormones and behavior</title><addtitle>Horm Behav</addtitle><description>The influence of progesterone in the brain and on the behavior of females is fairly well understood. However, less is known about the effect of progesterone in the male system. In male rats, receptors for progesterone are present in virtually all vasopressin (AVP) immunoreactive cells in the bed nucleus of the stria terminalis (BST) and the medial amygdala (MeA). This colocalization functions to regulate AVP expression, as progesterone and/or progestin receptors (PR)s suppress AVP expression in these same extrahypothalamic regions in the brain. These data suggest that progesterone may influence AVP-dependent behavior. While AVP is implicated in numerous behavioral and physiological functions in rodents, AVP appears essential for social recognition of conspecifics. Therefore, we examined the effects of progesterone on social recognition. We report that progesterone plays an important role in modulating social recognition in the male brain, as progesterone treatment leads to a significant impairment of social recognition in male rats. Moreover, progesterone appears to act on PRs to impair social recognition, as progesterone impairment of social recognition is blocked by a PR antagonist, RU-486. Social recognition is also impaired by a specific progestin agonist, R5020. Interestingly, we show that progesterone does not interfere with either general memory or olfactory processes, suggesting that progesterone seems critically important to social recognition memory. These data provide strong evidence that physiological levels of progesterone can have an important impact on social behavior in male rats.
► We report that progesterone is important in modulating social recognition in the male brain. ► Progesterone treatment leads to a significant impairment in social recognition in male rats. ► Progesterone impairment of social recognition is blocked by a PR antagonist, RU-486. ► Social recognition is also impaired by the synthetic progestin, R5020. ► Progesterone did not interfere with either general memory or olfactory processes.</description><subject>Amygdala - physiology</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Discrimination (Psychology) - drug effects</subject><subject>Feeding Behavior - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone Antagonists - pharmacology</subject><subject>Hormones and behavior</subject><subject>Male</subject><subject>Males</subject><subject>Mifepristone - pharmacology</subject><subject>Progesterone</subject><subject>Progesterone - toxicity</subject><subject>Progesterone Congeners - pharmacology</subject><subject>Progestin receptors</subject><subject>Promegestone - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychomotor Performance - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recognition (Psychology) - drug effects</subject><subject>Rodents</subject><subject>Septal Nuclei - physiology</subject><subject>Smell - drug effects</subject><subject>Social Behavior</subject><subject>Social memory</subject><subject>Social recognition behavior</subject><subject>Vasopressin</subject><subject>Vasopressins - physiology</subject><issn>0018-506X</issn><issn>1095-6867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQQEVISRy3vyAQlkCP686sVvLqkEAITVsItAcfehNa7awts5YcaR3Iv69SO2lyKQyIYd586DF2jjBDQPllPXtatbSaVYDVDHKAOmITBCVK2cj5MZsAYFMKkL9P2VlK65yiqOsTdlpVXMpcmLD6VwxLSiPF4Klwm61xMRUpWGeGIpINS-9GF3zhfLExAxXRjOkj-9CbIdGnwztli7uvi9vv5f3Pbz9ub-5LK1CMJWFDyG3LxZwTV1hX2M2haXpTt7wnZcn0memUBKyxb1qqOyDR55SM4nzKrvdjt7t2Q50lP0Yz6G10GxOfdDBOv694t9LL8Kg5z04Q8oDLw4AYHnb5l3oddtHnk7WSNUoFUmaI7yEbQ0qR-tcFCPpZtF7rv6L1s2gNOUDlrou3t732vJjNwOcDYJI1Qx-Nty7940SDFUiRuas9R1nko6Ook3XkLXUu6x91F9x_D_kDnTKdjQ</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Bychowski, Meaghan E.</creator><creator>Auger, Catherine J.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier BV</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>K9.</scope><scope>5PM</scope></search><sort><creationdate>20120401</creationdate><title>Progesterone impairs social recognition in male rats</title><author>Bychowski, Meaghan E. ; Auger, Catherine J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-e18e13cb3573e391421d7088fa4b3fe9ceafe18d960141f8be4d0e5f601ea933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Amygdala - physiology</topic><topic>Animal behavior</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Discrimination (Psychology) - drug effects</topic><topic>Feeding Behavior - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone Antagonists - pharmacology</topic><topic>Hormones and behavior</topic><topic>Male</topic><topic>Males</topic><topic>Mifepristone - pharmacology</topic><topic>Progesterone</topic><topic>Progesterone - toxicity</topic><topic>Progesterone Congeners - pharmacology</topic><topic>Progestin receptors</topic><topic>Promegestone - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychomotor Performance - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recognition (Psychology) - drug effects</topic><topic>Rodents</topic><topic>Septal Nuclei - physiology</topic><topic>Smell - drug effects</topic><topic>Social Behavior</topic><topic>Social memory</topic><topic>Social recognition behavior</topic><topic>Vasopressin</topic><topic>Vasopressins - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bychowski, Meaghan E.</creatorcontrib><creatorcontrib>Auger, Catherine J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hormones and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bychowski, Meaghan E.</au><au>Auger, Catherine J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progesterone impairs social recognition in male rats</atitle><jtitle>Hormones and behavior</jtitle><addtitle>Horm Behav</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>61</volume><issue>4</issue><spage>598</spage><epage>604</epage><pages>598-604</pages><issn>0018-506X</issn><eissn>1095-6867</eissn><coden>HOBEAO</coden><abstract>The influence of progesterone in the brain and on the behavior of females is fairly well understood. However, less is known about the effect of progesterone in the male system. In male rats, receptors for progesterone are present in virtually all vasopressin (AVP) immunoreactive cells in the bed nucleus of the stria terminalis (BST) and the medial amygdala (MeA). This colocalization functions to regulate AVP expression, as progesterone and/or progestin receptors (PR)s suppress AVP expression in these same extrahypothalamic regions in the brain. These data suggest that progesterone may influence AVP-dependent behavior. While AVP is implicated in numerous behavioral and physiological functions in rodents, AVP appears essential for social recognition of conspecifics. Therefore, we examined the effects of progesterone on social recognition. We report that progesterone plays an important role in modulating social recognition in the male brain, as progesterone treatment leads to a significant impairment of social recognition in male rats. Moreover, progesterone appears to act on PRs to impair social recognition, as progesterone impairment of social recognition is blocked by a PR antagonist, RU-486. Social recognition is also impaired by a specific progestin agonist, R5020. Interestingly, we show that progesterone does not interfere with either general memory or olfactory processes, suggesting that progesterone seems critically important to social recognition memory. These data provide strong evidence that physiological levels of progesterone can have an important impact on social behavior in male rats.
► We report that progesterone is important in modulating social recognition in the male brain. ► Progesterone treatment leads to a significant impairment in social recognition in male rats. ► Progesterone impairment of social recognition is blocked by a PR antagonist, RU-486. ► Social recognition is also impaired by the synthetic progestin, R5020. ► Progesterone did not interfere with either general memory or olfactory processes.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>22366506</pmid><doi>10.1016/j.yhbeh.2012.02.009</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amygdala - physiology Animal behavior Animals Behavioral psychophysiology Biological and medical sciences Discrimination (Psychology) - drug effects Feeding Behavior - drug effects Fundamental and applied biological sciences. Psychology Hormone Antagonists - pharmacology Hormones and behavior Male Males Mifepristone - pharmacology Progesterone Progesterone - toxicity Progesterone Congeners - pharmacology Progestin receptors Promegestone - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - physiology Rats Rats, Sprague-Dawley Recognition (Psychology) - drug effects Rodents Septal Nuclei - physiology Smell - drug effects Social Behavior Social memory Social recognition behavior Vasopressin Vasopressins - physiology |
| title | Progesterone impairs social recognition in male rats |
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