Potent synergistic effect of IL-3 and TNF on matrix metalloproteinase 9 generation by human eosinophils

► IL-3 in combination with TNF induces exuberant amounts of eosinophil MMP-9. ► The synergistic effect of IL-3/TNF is due to MMP-9 synthesis by eosinophils. ► Enhanced mRNA stabilization is associated with the synergistic induction of MMP-9. ► MMP-9 synthesis requires the interaction of multiple sig...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2012-05, Vol.58 (2), p.199-206
Hauptverfasser:	Kelly, Elizabeth A.B., Liu, Lin Ying, Esnault, Stephane, Quinchia Johnson, Beatriz Helena, Jarjour, Nizar N.
Format:	Artikel
Sprache:	eng
Schlagworte:	c-Jun amino-terminal kinase Cell activation Cell culture chemokines Cytokines - metabolism Enzyme-Linked Immunosorbent Assay eosinophils Eosinophils - metabolism Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Flow Cytometry gamma -Interferon gelatin Gelatinase B Granulocyte-macrophage colony-stimulating factor Helper cells Humans IL-3 IL-5 Immunoblotting Interleukin 3 Interleukin 4 Interleukin 5 Interleukin-3 - metabolism Intracellular signalling Leukocytes (eosinophilic) Life Sciences Lymphocytes T MAP kinase Matrix metalloproteinase Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism MEK kinase mitogen-activated protein kinase mitogen-activated protein kinase kinase kinase MMP-9 mRNA stability NF- Kappa B protein Phosphorylation Polymerase chain reaction Post-transcription quantitative polymerase chain reaction Real-Time Polymerase Chain Reaction RNA, Messenger - genetics Signal transduction Statistical analysis Synergism Transcription factors Tumor necrosis factor Tumor necrosis factor- alpha Tumor Necrosis Factor-alpha - metabolism
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