Radiation Dose–Volume Effects in Radiation-Induced Rectal Injury
The available dose/volume/outcome data for rectal injury were reviewed. The volume of rectum receiving ≥60Gy is consistently associated with the risk of Grade ≥2 rectal toxicity or rectal bleeding. Parameters for the Lyman-Kutcher-Burman normal tissue complication probability model from four clinica...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2010-03, Vol.76 (3), p.S123-S129 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | Michalski, Jeff M., M.D Gay, Hiram, M.D Jackson, Andrew, M.D Tucker, Susan L., Ph.D Deasy, Joseph O., Ph.D |
| description | The available dose/volume/outcome data for rectal injury were reviewed. The volume of rectum receiving ≥60Gy is consistently associated with the risk of Grade ≥2 rectal toxicity or rectal bleeding. Parameters for the Lyman-Kutcher-Burman normal tissue complication probability model from four clinical series are remarkably consistent, suggesting that high doses are predominant in determining the risk of toxicity. The best overall estimates (95% confidence interval) of the Lyman-Kutcher-Burman model parameters are n = 0.09 (0.04–0.14); m = 0.13 (0.10–0.17); and TD50 = 76.9 (73.7–80.1) Gy. Most of the models of late radiation toxicity come from three-dimensional conformal radiotherapy dose-escalation studies of early-stage prostate cancer. It is possible that intensity-modulated radiotherapy or proton beam dose distributions require modification of these models because of the inherent differences in low and intermediate dose distributions. |
| doi_str_mv | 10.1016/j.ijrobp.2009.03.078 |
| format | Article |
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The volume of rectum receiving ≥60Gy is consistently associated with the risk of Grade ≥2 rectal toxicity or rectal bleeding. Parameters for the Lyman-Kutcher-Burman normal tissue complication probability model from four clinical series are remarkably consistent, suggesting that high doses are predominant in determining the risk of toxicity. The best overall estimates (95% confidence interval) of the Lyman-Kutcher-Burman model parameters are n = 0.09 (0.04–0.14); m = 0.13 (0.10–0.17); and TD50 = 76.9 (73.7–80.1) Gy. Most of the models of late radiation toxicity come from three-dimensional conformal radiotherapy dose-escalation studies of early-stage prostate cancer. It is possible that intensity-modulated radiotherapy or proton beam dose distributions require modification of these models because of the inherent differences in low and intermediate dose distributions.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2009.03.078</identifier><identifier>PMID: 20171506</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>BEAMS ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; BODY ; DIGESTIVE SYSTEM ; DISEASES ; DOSES ; Forecasting ; Gastrointestinal Hemorrhage - etiology ; GASTROINTESTINAL TRACT ; GLANDS ; HAZARDS ; HEALTH HAZARDS ; Hematology, Oncology and Palliative Medicine ; Humans ; INJURIES ; INTESTINES ; LARGE INTESTINE ; MALE GENITALS ; MEDICINE ; Models, Biological ; Models, Statistical ; NEOPLASMS ; NTCP ; NUCLEAR MEDICINE ; NUCLEON BEAMS ; ORGANS ; PARTICLE BEAMS ; PROSTATE ; PROTON BEAMS ; RADIATION DOSE DISTRIBUTIONS ; RADIATION DOSES ; RADIATION EFFECTS ; RADIATION INJURIES ; Radiation Injuries - complications ; Radiation injury ; Radiography ; RADIOLOGY ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; Radiotherapy Dosage ; Radiotherapy, Conformal - adverse effects ; RECTUM ; Rectum - diagnostic imaging ; Rectum - radiation effects ; Risk ; THERAPY ; THREE-DIMENSIONAL CALCULATIONS ; TOXICITY</subject><ispartof>International journal of radiation oncology, biology, physics, 2010-03, Vol.76 (3), p.S123-S129</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>Copyright 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-ba1ac69443e4db0982daeb8cc4867f37c598aaed533591125983399039440d193</citedby><cites>FETCH-LOGICAL-c611t-ba1ac69443e4db0982daeb8cc4867f37c598aaed533591125983399039440d193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S036030160903291X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20171506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/21372140$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Michalski, Jeff M., M.D</creatorcontrib><creatorcontrib>Gay, Hiram, M.D</creatorcontrib><creatorcontrib>Jackson, Andrew, M.D</creatorcontrib><creatorcontrib>Tucker, Susan L., Ph.D</creatorcontrib><creatorcontrib>Deasy, Joseph O., Ph.D</creatorcontrib><title>Radiation Dose–Volume Effects in Radiation-Induced Rectal Injury</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>The available dose/volume/outcome data for rectal injury were reviewed. The volume of rectum receiving ≥60Gy is consistently associated with the risk of Grade ≥2 rectal toxicity or rectal bleeding. Parameters for the Lyman-Kutcher-Burman normal tissue complication probability model from four clinical series are remarkably consistent, suggesting that high doses are predominant in determining the risk of toxicity. The best overall estimates (95% confidence interval) of the Lyman-Kutcher-Burman model parameters are n = 0.09 (0.04–0.14); m = 0.13 (0.10–0.17); and TD50 = 76.9 (73.7–80.1) Gy. Most of the models of late radiation toxicity come from three-dimensional conformal radiotherapy dose-escalation studies of early-stage prostate cancer. It is possible that intensity-modulated radiotherapy or proton beam dose distributions require modification of these models because of the inherent differences in low and intermediate dose distributions.</description><subject>BEAMS</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BODY</subject><subject>DIGESTIVE SYSTEM</subject><subject>DISEASES</subject><subject>DOSES</subject><subject>Forecasting</subject><subject>Gastrointestinal Hemorrhage - etiology</subject><subject>GASTROINTESTINAL TRACT</subject><subject>GLANDS</subject><subject>HAZARDS</subject><subject>HEALTH HAZARDS</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>INJURIES</subject><subject>INTESTINES</subject><subject>LARGE INTESTINE</subject><subject>MALE GENITALS</subject><subject>MEDICINE</subject><subject>Models, Biological</subject><subject>Models, Statistical</subject><subject>NEOPLASMS</subject><subject>NTCP</subject><subject>NUCLEAR MEDICINE</subject><subject>NUCLEON BEAMS</subject><subject>ORGANS</subject><subject>PARTICLE BEAMS</subject><subject>PROSTATE</subject><subject>PROTON BEAMS</subject><subject>RADIATION DOSE DISTRIBUTIONS</subject><subject>RADIATION DOSES</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION INJURIES</subject><subject>Radiation Injuries - complications</subject><subject>Radiation injury</subject><subject>Radiography</subject><subject>RADIOLOGY</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy, Conformal - adverse effects</subject><subject>RECTUM</subject><subject>Rectum - diagnostic imaging</subject><subject>Rectum - radiation effects</subject><subject>Risk</subject><subject>THERAPY</subject><subject>THREE-DIMENSIONAL CALCULATIONS</subject><subject>TOXICITY</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9O3DAQxi3UCra0b4CqSD0nnYnzz5dKLaWwEhIS0Iqb5dgOOGTtlZ0g7a3v0Dfsk-BoYUt76cmy5ptvvvkNIUcIGQJWH_vM9N616ywHYBnQDOpmjyywqVlKy_LmFVkArSClUXxA3oTQAwBiXeyTgxywxhKqBflyKZQRo3E2-eqC_v3z1w83TCudnHSdlmNIjE12knRp1SS1Si5jSQzJ0vaT37wlrzsxBP3u6T0k37-dXB-fpecXp8vjz-eprBDHtBUoZMWKgupCtcCaXAndNlIWTVV3tJYla4TQqqS0ZIh5_FLKGNDYAgoZPSSftr7rqV1pJbUdvRj42puV8BvuhOF_V6y547fugVOKrKjqaPBha-DCaHiQZtTyTjpr4zY8R1rnWEBUFVuV9C4Er7vdBAQ-k-c935LnM3kOlEfyse39y3S7pmfUf-LryOjBaD8n0DbiNH4OoJz534R_DeRgrJFiuNcbHXo3eRv5c-Qh58Cv5uvPx4fIMGd4Qx8BVdisLA</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Michalski, Jeff M., M.D</creator><creator>Gay, Hiram, M.D</creator><creator>Jackson, Andrew, M.D</creator><creator>Tucker, Susan L., Ph.D</creator><creator>Deasy, Joseph O., Ph.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>20100301</creationdate><title>Radiation Dose–Volume Effects in Radiation-Induced Rectal Injury</title><author>Michalski, Jeff M., M.D ; Gay, Hiram, M.D ; Jackson, Andrew, M.D ; Tucker, Susan L., Ph.D ; Deasy, Joseph O., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-ba1ac69443e4db0982daeb8cc4867f37c598aaed533591125983399039440d193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>BEAMS</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BODY</topic><topic>DIGESTIVE SYSTEM</topic><topic>DISEASES</topic><topic>DOSES</topic><topic>Forecasting</topic><topic>Gastrointestinal Hemorrhage - etiology</topic><topic>GASTROINTESTINAL TRACT</topic><topic>GLANDS</topic><topic>HAZARDS</topic><topic>HEALTH HAZARDS</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>INJURIES</topic><topic>INTESTINES</topic><topic>LARGE INTESTINE</topic><topic>MALE GENITALS</topic><topic>MEDICINE</topic><topic>Models, Biological</topic><topic>Models, Statistical</topic><topic>NEOPLASMS</topic><topic>NTCP</topic><topic>NUCLEAR MEDICINE</topic><topic>NUCLEON BEAMS</topic><topic>ORGANS</topic><topic>PARTICLE BEAMS</topic><topic>PROSTATE</topic><topic>PROTON BEAMS</topic><topic>RADIATION DOSE DISTRIBUTIONS</topic><topic>RADIATION DOSES</topic><topic>RADIATION EFFECTS</topic><topic>RADIATION INJURIES</topic><topic>Radiation Injuries - complications</topic><topic>Radiation injury</topic><topic>Radiography</topic><topic>RADIOLOGY</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOTHERAPY</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy, Conformal - adverse effects</topic><topic>RECTUM</topic><topic>Rectum - diagnostic imaging</topic><topic>Rectum - radiation effects</topic><topic>Risk</topic><topic>THERAPY</topic><topic>THREE-DIMENSIONAL CALCULATIONS</topic><topic>TOXICITY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Michalski, Jeff M., M.D</creatorcontrib><creatorcontrib>Gay, Hiram, M.D</creatorcontrib><creatorcontrib>Jackson, Andrew, M.D</creatorcontrib><creatorcontrib>Tucker, Susan L., Ph.D</creatorcontrib><creatorcontrib>Deasy, Joseph O., Ph.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Michalski, Jeff M., M.D</au><au>Gay, Hiram, M.D</au><au>Jackson, Andrew, M.D</au><au>Tucker, Susan L., Ph.D</au><au>Deasy, Joseph O., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiation Dose–Volume Effects in Radiation-Induced Rectal Injury</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>76</volume><issue>3</issue><spage>S123</spage><epage>S129</epage><pages>S123-S129</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>The available dose/volume/outcome data for rectal injury were reviewed. The volume of rectum receiving ≥60Gy is consistently associated with the risk of Grade ≥2 rectal toxicity or rectal bleeding. Parameters for the Lyman-Kutcher-Burman normal tissue complication probability model from four clinical series are remarkably consistent, suggesting that high doses are predominant in determining the risk of toxicity. The best overall estimates (95% confidence interval) of the Lyman-Kutcher-Burman model parameters are n = 0.09 (0.04–0.14); m = 0.13 (0.10–0.17); and TD50 = 76.9 (73.7–80.1) Gy. Most of the models of late radiation toxicity come from three-dimensional conformal radiotherapy dose-escalation studies of early-stage prostate cancer. It is possible that intensity-modulated radiotherapy or proton beam dose distributions require modification of these models because of the inherent differences in low and intermediate dose distributions.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20171506</pmid><doi>10.1016/j.ijrobp.2009.03.078</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3016 |
| ispartof | International journal of radiation oncology, biology, physics, 2010-03, Vol.76 (3), p.S123-S129 |
| issn | 0360-3016 1879-355X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | BEAMS BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BODY DIGESTIVE SYSTEM DISEASES DOSES Forecasting Gastrointestinal Hemorrhage - etiology GASTROINTESTINAL TRACT GLANDS HAZARDS HEALTH HAZARDS Hematology, Oncology and Palliative Medicine Humans INJURIES INTESTINES LARGE INTESTINE MALE GENITALS MEDICINE Models, Biological Models, Statistical NEOPLASMS NTCP NUCLEAR MEDICINE NUCLEON BEAMS ORGANS PARTICLE BEAMS PROSTATE PROTON BEAMS RADIATION DOSE DISTRIBUTIONS RADIATION DOSES RADIATION EFFECTS RADIATION INJURIES Radiation Injuries - complications Radiation injury Radiography RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage Radiotherapy, Conformal - adverse effects RECTUM Rectum - diagnostic imaging Rectum - radiation effects Risk THERAPY THREE-DIMENSIONAL CALCULATIONS TOXICITY |
| title | Radiation Dose–Volume Effects in Radiation-Induced Rectal Injury |
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