Succinate Dehydrogenase (SDH) D Subunit (SDHD) Inactivation in a Growth-Hormone-Producing Pituitary Tumor: A New Association for SDH?

Background: Mutations in the subunits B, C, and D of succinate dehydrogenase (SDH) mitochondrial complex II have been associated with the development of paragangliomas (PGL), gastrointestinal stromal tumors, papillary thyroid and renal carcinoma (SDHB), and testicular seminoma (SDHD). Aim: Our aim w...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2012-03, Vol.97 (3), p.E357-E366
Hauptverfasser:	Xekouki, Paraskevi, Pacak, Karel, Almeida, Madson, Wassif, Christopher A, Rustin, Pierre, Nesterova, Maria, de la Luz Sierra, Maria, Matro, Joey, Ball, Evan, Azevedo, Monalisa, Horvath, Anelia, Lyssikatos, Charalampos, Quezado, Martha, Patronas, Nicholas, Ferrando, Barbara, Pasini, Barbara, Lytras, Aristides, Tolis, George, Stratakis, Constantine A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acromegaly - genetics Acromegaly - metabolism Adenoma - genetics Adenoma - metabolism Adult Codon, Nonsense Frameshift Mutation Genetic Loci Germ-Line Mutation Growth Hormone - metabolism Hot Topics in Translational Endocrinology Humans Hypertension - genetics Hypertension - metabolism Loss of Heterozygosity Male Pituitary Neoplasms - genetics Pituitary Neoplasms - metabolism Succinate Dehydrogenase - genetics Succinate Dehydrogenase - metabolism
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