Evaluation of Specific Metabolic Rates of Major Organs and Tissues: Comparison Between Nonobese and Obese Women
Elia (1992) identified the specific resting metabolic rates (Ki) of major organs and tissues in young adults with normal weight: 200 for liver, 240 for brain, 440 for heart and kidneys, 13 for skeletal muscle, 4.5 for adipose tissue and 12 for residual mass (all units in kcal/kg per day). The aim of...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2012-01, Vol.20 (1), p.95-100 |
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| creator | Wang, ZiMian Ying, Zhiliang Bosy‐Westphal, Anja Zhang, Junyi Heller, Martin Later, Wiebke Heymsfield, Steven B. Müller, Manfred J. |
| description | Elia (1992) identified the specific resting metabolic rates (Ki) of major organs and tissues in young adults with normal weight: 200 for liver, 240 for brain, 440 for heart and kidneys, 13 for skeletal muscle, 4.5 for adipose tissue and 12 for residual mass (all units in kcal/kg per day). The aim of the present study was to assess the applicability of Elia's Ki values for obese adults. A sample of young women (n = 80) was divided into two groups, nonobese (BMI |
| doi_str_mv | 10.1038/oby.2011.256 |
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The aim of the present study was to assess the applicability of Elia's Ki values for obese adults. A sample of young women (n = 80) was divided into two groups, nonobese (BMI <29.9 kg/m2) and obese (BMI 30.0–43.2 kg/m2). This study was based on the mechanistic model: REE = σ (Ki × Ti), where REE is whole‐body resting energy expenditure measured by indirect calorimetry and Ti is the mass of individual organs and tissues measured by magnetic resonance imaging. For each organ/tissue, the corresponding Elia's Ki value was analyzed respectively for nonobese and obese groups by using stepwise univariate regression analysis. Elia's Ki values were within the range of 95% confidence intervals (CIs) in the nonobese group. However, Elia's Ki values were outside the right boundaries of 95% CIs in the obese group and a corresponding obesity‐adjusted coefficient was calculated as 0.98, indicating that Elia's values overestimate Ki by 2.0% in obese adults. Obesity‐adjusted Ki values were 196 for liver, 235 for brain, 431 for heart and kidneys, 12.7 for skeletal muscle, 4.4 for adipose tissue, and 11.8 for residual mass. In conclusion, although Elia's Ki values were validated in nonobese women, obesity‐adjustments are appropriate for application in obese women.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>EISSN: 1930-7381</identifier><identifier>DOI: 10.1038/oby.2011.256</identifier><identifier>PMID: 21836642</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adipose Tissue - metabolism ; Adult ; Analysis of Variance ; Brain - metabolism ; Comparative studies ; Energy Metabolism ; Female ; Humans ; Kidney - metabolism ; Liver - metabolism ; Magnetic Resonance Imaging ; Metabolism ; Models, Biological ; Muscle, Skeletal - metabolism ; Myocardium - metabolism ; Obesity - metabolism ; Weight ; Women</subject><ispartof>Obesity (Silver Spring, Md.), 2012-01, Vol.20 (1), p.95-100</ispartof><rights>2012 North American Association for the Study of Obesity (NAASO)</rights><rights>Copyright Nature Publishing Group Jan 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5186-2e98080fda109d1d706b2b881174aaa85dca8b5d086f8a7698e78843e5ba3623</citedby><cites>FETCH-LOGICAL-c5186-2e98080fda109d1d706b2b881174aaa85dca8b5d086f8a7698e78843e5ba3623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1038%2Foby.2011.256$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1038%2Foby.2011.256$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21836642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, ZiMian</creatorcontrib><creatorcontrib>Ying, Zhiliang</creatorcontrib><creatorcontrib>Bosy‐Westphal, Anja</creatorcontrib><creatorcontrib>Zhang, Junyi</creatorcontrib><creatorcontrib>Heller, Martin</creatorcontrib><creatorcontrib>Later, Wiebke</creatorcontrib><creatorcontrib>Heymsfield, Steven B.</creatorcontrib><creatorcontrib>Müller, Manfred J.</creatorcontrib><title>Evaluation of Specific Metabolic Rates of Major Organs and Tissues: Comparison Between Nonobese and Obese Women</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Elia (1992) identified the specific resting metabolic rates (Ki) of major organs and tissues in young adults with normal weight: 200 for liver, 240 for brain, 440 for heart and kidneys, 13 for skeletal muscle, 4.5 for adipose tissue and 12 for residual mass (all units in kcal/kg per day). The aim of the present study was to assess the applicability of Elia's Ki values for obese adults. A sample of young women (n = 80) was divided into two groups, nonobese (BMI <29.9 kg/m2) and obese (BMI 30.0–43.2 kg/m2). This study was based on the mechanistic model: REE = σ (Ki × Ti), where REE is whole‐body resting energy expenditure measured by indirect calorimetry and Ti is the mass of individual organs and tissues measured by magnetic resonance imaging. For each organ/tissue, the corresponding Elia's Ki value was analyzed respectively for nonobese and obese groups by using stepwise univariate regression analysis. Elia's Ki values were within the range of 95% confidence intervals (CIs) in the nonobese group. However, Elia's Ki values were outside the right boundaries of 95% CIs in the obese group and a corresponding obesity‐adjusted coefficient was calculated as 0.98, indicating that Elia's values overestimate Ki by 2.0% in obese adults. Obesity‐adjusted Ki values were 196 for liver, 235 for brain, 431 for heart and kidneys, 12.7 for skeletal muscle, 4.4 for adipose tissue, and 11.8 for residual mass. In conclusion, although Elia's Ki values were validated in nonobese women, obesity‐adjustments are appropriate for application in obese women.</description><subject>Adipose Tissue - metabolism</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Brain - metabolism</subject><subject>Comparative studies</subject><subject>Energy Metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney - metabolism</subject><subject>Liver - metabolism</subject><subject>Magnetic Resonance Imaging</subject><subject>Metabolism</subject><subject>Models, Biological</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Myocardium - metabolism</subject><subject>Obesity - metabolism</subject><subject>Weight</subject><subject>Women</subject><issn>1930-7381</issn><issn>1930-739X</issn><issn>1930-7381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0Eoh9w44wiLly6i8dOHIcDEl2VD6llJVgJOFmTZFK8SuzFTlrtv8fbLSvgwGleaR69mtHD2DPgc-BSv_L1di44wFwU6gE7hkryWSmrbw8PWcMRO4lxzXmueAGP2ZEALZXKxTHzFzfYTzha7zLfZV821NjONtkVjVj7PqXPOFLc7a5w7UO2DNfoYoauzVY2xoni62zhhw0GG1PHOY23RC775J2vKdIduLxLX_1A7gl71GEf6en9PGWrdxerxYfZ5fL9x8Xby1lTgFYzQZXmmnctAq9aaEuualFrDVDmiKiLtkFdFy3XqtNYqkpTqXUuqahRKiFP2Zt97WaqB2obcmPA3myCHTBsjUdr_t44-8Nc-xsjJVRc8lTw8r4g-J_pydEMNjbU9-jIT9FUIFSeS5CJfPEPufZTcOm5HZSYXKgEne2hJvgYA3WHU4CbnUaTNJqdRpM0Jvz5n-cf4N_eEgB74Nb2tP1vmVmefxdSKvkLJE2ong</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Wang, ZiMian</creator><creator>Ying, Zhiliang</creator><creator>Bosy‐Westphal, Anja</creator><creator>Zhang, Junyi</creator><creator>Heller, Martin</creator><creator>Later, Wiebke</creator><creator>Heymsfield, Steven B.</creator><creator>Müller, Manfred J.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201201</creationdate><title>Evaluation of Specific Metabolic Rates of Major Organs and Tissues: Comparison Between Nonobese and Obese Women</title><author>Wang, ZiMian ; Ying, Zhiliang ; Bosy‐Westphal, Anja ; Zhang, Junyi ; Heller, Martin ; Later, Wiebke ; Heymsfield, Steven B. ; Müller, Manfred J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5186-2e98080fda109d1d706b2b881174aaa85dca8b5d086f8a7698e78843e5ba3623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Brain - metabolism</topic><topic>Comparative studies</topic><topic>Energy Metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney - metabolism</topic><topic>Liver - metabolism</topic><topic>Magnetic Resonance Imaging</topic><topic>Metabolism</topic><topic>Models, Biological</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Myocardium - metabolism</topic><topic>Obesity - metabolism</topic><topic>Weight</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, ZiMian</creatorcontrib><creatorcontrib>Ying, Zhiliang</creatorcontrib><creatorcontrib>Bosy‐Westphal, Anja</creatorcontrib><creatorcontrib>Zhang, Junyi</creatorcontrib><creatorcontrib>Heller, Martin</creatorcontrib><creatorcontrib>Later, Wiebke</creatorcontrib><creatorcontrib>Heymsfield, Steven B.</creatorcontrib><creatorcontrib>Müller, Manfred J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, ZiMian</au><au>Ying, Zhiliang</au><au>Bosy‐Westphal, Anja</au><au>Zhang, Junyi</au><au>Heller, Martin</au><au>Later, Wiebke</au><au>Heymsfield, Steven B.</au><au>Müller, Manfred J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Specific Metabolic Rates of Major Organs and Tissues: Comparison Between Nonobese and Obese Women</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2012-01</date><risdate>2012</risdate><volume>20</volume><issue>1</issue><spage>95</spage><epage>100</epage><pages>95-100</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><eissn>1930-7381</eissn><abstract>Elia (1992) identified the specific resting metabolic rates (Ki) of major organs and tissues in young adults with normal weight: 200 for liver, 240 for brain, 440 for heart and kidneys, 13 for skeletal muscle, 4.5 for adipose tissue and 12 for residual mass (all units in kcal/kg per day). The aim of the present study was to assess the applicability of Elia's Ki values for obese adults. A sample of young women (n = 80) was divided into two groups, nonobese (BMI <29.9 kg/m2) and obese (BMI 30.0–43.2 kg/m2). This study was based on the mechanistic model: REE = σ (Ki × Ti), where REE is whole‐body resting energy expenditure measured by indirect calorimetry and Ti is the mass of individual organs and tissues measured by magnetic resonance imaging. For each organ/tissue, the corresponding Elia's Ki value was analyzed respectively for nonobese and obese groups by using stepwise univariate regression analysis. Elia's Ki values were within the range of 95% confidence intervals (CIs) in the nonobese group. However, Elia's Ki values were outside the right boundaries of 95% CIs in the obese group and a corresponding obesity‐adjusted coefficient was calculated as 0.98, indicating that Elia's values overestimate Ki by 2.0% in obese adults. Obesity‐adjusted Ki values were 196 for liver, 235 for brain, 431 for heart and kidneys, 12.7 for skeletal muscle, 4.4 for adipose tissue, and 11.8 for residual mass. In conclusion, although Elia's Ki values were validated in nonobese women, obesity‐adjustments are appropriate for application in obese women.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21836642</pmid><doi>10.1038/oby.2011.256</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose Tissue - metabolism Adult Analysis of Variance Brain - metabolism Comparative studies Energy Metabolism Female Humans Kidney - metabolism Liver - metabolism Magnetic Resonance Imaging Metabolism Models, Biological Muscle, Skeletal - metabolism Myocardium - metabolism Obesity - metabolism Weight Women |
| title | Evaluation of Specific Metabolic Rates of Major Organs and Tissues: Comparison Between Nonobese and Obese Women |
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