Formation of a stable complex between the human immunodeficiency virus integrase protein and viral DNA

The integrase (IN) protein of the human immunodeficiency virus (HIV) mediates two distinct reactions: (i) specific removal of two nucleotides from the 3′ ends of the viral DNA and (ii) integration of the viral DNA into target DNA. Although IN discriminates between specific (viral) DNA and nonspecifi...

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Veröffentlicht in:	Nucleic acids research 1994-10, Vol.22 (20), p.4103-4110
Hauptverfasser:	Vink, Comelis, Lutzke, Ramon A.Puras, Plasterk, Ronald H.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Base Sequence Binding Sites Binding, Competitive Cations, Divalent Cross-Linking Reagents DNA Nucleotidyltransferases - metabolism DNA, Viral - metabolism HIV-1 - enzymology Human immunodeficiency virus 1 Integrases Manganese - pharmacology Molecular Sequence Data Substrate Specificity Virus Integration
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