Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells

Rejuvenation of telomeres with various lengths has been found in induced pluripotent stem cells （iPSCs）. Mechanisms of telomere length regulation during induction and proliferation of iPSCs remain elusive. We show that telomere dynamics are variable in mouse iPSCs during reprogramming and passage, a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell research 2012-04, Vol.22 (4), p.757-768
Hauptverfasser:	Wang, Fang, Yin, Yu, Ye, Xiaoying, Liu, Kai, Zhu, Haiying, Wang, Lingling, Chiourea, Maria, Okuka, Maja, Ji, Guangzhen, Dan, Jiameng, Zuo, Bingfeng, Li, Minshu, Zhang, Qian, Liu, Na, Chen, Lingyi, Pan, Xinghua, Gagos, Sarantis, Keefe, David L, Liu, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Cell Biology Cell Differentiation - genetics Cells, Cultured Cellular Reprogramming Cloning Elongation Embryo cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Fibroblasts - cytology Gene Expression Heterogeneity In Situ Hybridization, Fluorescence Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Inhibitory postsynaptic potentials Life Sciences Mice Original original-article Recombination Recombination, Genetic - genetics somatic cell nuclear transfer Stem cells Telomerase Telomerase - deficiency Telomerase - genetics Telomerase - metabolism Telomere - genetics Telomere - metabolism Telomere Homeostasis - genetics Telomeres Transcription Factors - genetics Transcription Factors - metabolism 体细胞核移植分子多能干细胞异质性端粒长度诱导调控机制重新编程
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!