Development of Film Dosage Form Containing Allopurinol for Prevention and Treatment of Oral Mucositis

Development of Film Dosage Form Containing Allopurinol for Prevention and Treatment of Oral Mucositis

Film dosage forms (FDs) containing allopurinol (AP) were prepared using a casting method with water-soluble polysaccharides, such as sodium alginate (ALG), and the release profile of AP from FDs was investigated in limited dissolution medium. Some ALGs were able to form FDs incorporating AP, and the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ISRN pharmaceutics 2012, Vol.2012 (2012), p.1-5
Hauptverfasser: Murata, Yoshifumi, Kofuji, Kyoko, Nishida, Norihisa, Kamaguchi, Ryosei
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 5
container_issue 2012
container_start_page 1
container_title ISRN pharmaceutics
container_volume 2012
creator Murata, Yoshifumi
Kofuji, Kyoko
Nishida, Norihisa
Kamaguchi, Ryosei
description Film dosage forms (FDs) containing allopurinol (AP) were prepared using a casting method with water-soluble polysaccharides, such as sodium alginate (ALG), and the release profile of AP from FDs was investigated in limited dissolution medium. Some ALGs were able to form FDs incorporating AP, and the thickness was about 50 μm. All FDs were easy to handle, though the rheological properties varied with ALG species. AP was homogenously present throughout the FDs and was released with disintegration in 10 mL of physiological saline. These results confirmed that FDs are useful for preventing or treating localized problems in the oral cavity, such as mucositis. FDs are also useful for administering drugs to cancer patients receiving chemotherapy and/or radiotherapy.
doi_str_mv 10.5402/2012/764510
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3317059</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>968103320</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2820-caa41cc0a8985892e67c6453bdf8c85f2ba262d5ff781b7602fd9750c7b7ba633</originalsourceid><addsrcrecordid>eNqFkc9rHCEYhqU0NCHJqecWb4WGbT51_DGXQthk20JKekjP4ji6sczoVmdS8t_HMMnSnupFwcfne-VF6C2BT7wBek6B0HMpGk7gFTqi0MJKEM5e788NP0SnpfyCugRwrtQbdEhpIxsB6gi5S3fvhrQbXZxw8ngThhFfpmK2Dm9SHvE6xcmEGOIWXwwVnHOIacA-Zfwj17dxCiliE3t8m52ZXjw32Qz4-2xTCVMoJ-jAm6G40-f9GP3cXN2uv66ub758W19cryxVFFbWmIZYC0a1iquWOiFt_Rrreq-s4p52hgrac--lIp0UQH3fSg5WdrIzgrFj9Hnx7uZudL2tYWoOvcthNPlBJxP0vzcx3OltuteMEQm8rYIPz4Kcfs-uTHoMxbphMNGluehWKAKMUajk2ULanErJzu-nENBP1einavRSTaXf_x1sz74UUYGPC3AXYm_-hP_Y3i2wq4jzZg83rWiVZI8z06Dl</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>968103320</pqid></control><display><type>article</type><title>Development of Film Dosage Form Containing Allopurinol for Prevention and Treatment of Oral Mucositis</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Murata, Yoshifumi ; Kofuji, Kyoko ; Nishida, Norihisa ; Kamaguchi, Ryosei</creator><contributor>Ragno, G.</contributor><creatorcontrib>Murata, Yoshifumi ; Kofuji, Kyoko ; Nishida, Norihisa ; Kamaguchi, Ryosei ; Ragno, G.</creatorcontrib><description>Film dosage forms (FDs) containing allopurinol (AP) were prepared using a casting method with water-soluble polysaccharides, such as sodium alginate (ALG), and the release profile of AP from FDs was investigated in limited dissolution medium. Some ALGs were able to form FDs incorporating AP, and the thickness was about 50 μm. All FDs were easy to handle, though the rheological properties varied with ALG species. AP was homogenously present throughout the FDs and was released with disintegration in 10 mL of physiological saline. These results confirmed that FDs are useful for preventing or treating localized problems in the oral cavity, such as mucositis. FDs are also useful for administering drugs to cancer patients receiving chemotherapy and/or radiotherapy.</description><identifier>ISSN: 2090-6145</identifier><identifier>ISSN: 2090-6153</identifier><identifier>EISSN: 2090-6153</identifier><identifier>DOI: 10.5402/2012/764510</identifier><identifier>PMID: 22474608</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><ispartof>ISRN pharmaceutics, 2012, Vol.2012 (2012), p.1-5</ispartof><rights>Copyright © 2012 Yoshifumi Murata et al.</rights><rights>Copyright © 2012 Yoshifumi Murata et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2820-caa41cc0a8985892e67c6453bdf8c85f2ba262d5ff781b7602fd9750c7b7ba633</citedby><cites>FETCH-LOGICAL-c2820-caa41cc0a8985892e67c6453bdf8c85f2ba262d5ff781b7602fd9750c7b7ba633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317059/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317059/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,4025,27928,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22474608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ragno, G.</contributor><creatorcontrib>Murata, Yoshifumi</creatorcontrib><creatorcontrib>Kofuji, Kyoko</creatorcontrib><creatorcontrib>Nishida, Norihisa</creatorcontrib><creatorcontrib>Kamaguchi, Ryosei</creatorcontrib><title>Development of Film Dosage Form Containing Allopurinol for Prevention and Treatment of Oral Mucositis</title><title>ISRN pharmaceutics</title><addtitle>ISRN Pharm</addtitle><description>Film dosage forms (FDs) containing allopurinol (AP) were prepared using a casting method with water-soluble polysaccharides, such as sodium alginate (ALG), and the release profile of AP from FDs was investigated in limited dissolution medium. Some ALGs were able to form FDs incorporating AP, and the thickness was about 50 μm. All FDs were easy to handle, though the rheological properties varied with ALG species. AP was homogenously present throughout the FDs and was released with disintegration in 10 mL of physiological saline. These results confirmed that FDs are useful for preventing or treating localized problems in the oral cavity, such as mucositis. FDs are also useful for administering drugs to cancer patients receiving chemotherapy and/or radiotherapy.</description><issn>2090-6145</issn><issn>2090-6153</issn><issn>2090-6153</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><recordid>eNqFkc9rHCEYhqU0NCHJqecWb4WGbT51_DGXQthk20JKekjP4ji6sczoVmdS8t_HMMnSnupFwcfne-VF6C2BT7wBek6B0HMpGk7gFTqi0MJKEM5e788NP0SnpfyCugRwrtQbdEhpIxsB6gi5S3fvhrQbXZxw8ngThhFfpmK2Dm9SHvE6xcmEGOIWXwwVnHOIacA-Zfwj17dxCiliE3t8m52ZXjw32Qz4-2xTCVMoJ-jAm6G40-f9GP3cXN2uv66ub758W19cryxVFFbWmIZYC0a1iquWOiFt_Rrreq-s4p52hgrac--lIp0UQH3fSg5WdrIzgrFj9Hnx7uZudL2tYWoOvcthNPlBJxP0vzcx3OltuteMEQm8rYIPz4Kcfs-uTHoMxbphMNGluehWKAKMUajk2ULanErJzu-nENBP1einavRSTaXf_x1sz74UUYGPC3AXYm_-hP_Y3i2wq4jzZg83rWiVZI8z06Dl</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Murata, Yoshifumi</creator><creator>Kofuji, Kyoko</creator><creator>Nishida, Norihisa</creator><creator>Kamaguchi, Ryosei</creator><general>Hindawi Puplishing Corporation</general><general>International Scholarly Research Network</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2012</creationdate><title>Development of Film Dosage Form Containing Allopurinol for Prevention and Treatment of Oral Mucositis</title><author>Murata, Yoshifumi ; Kofuji, Kyoko ; Nishida, Norihisa ; Kamaguchi, Ryosei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2820-caa41cc0a8985892e67c6453bdf8c85f2ba262d5ff781b7602fd9750c7b7ba633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murata, Yoshifumi</creatorcontrib><creatorcontrib>Kofuji, Kyoko</creatorcontrib><creatorcontrib>Nishida, Norihisa</creatorcontrib><creatorcontrib>Kamaguchi, Ryosei</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>ISRN pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murata, Yoshifumi</au><au>Kofuji, Kyoko</au><au>Nishida, Norihisa</au><au>Kamaguchi, Ryosei</au><au>Ragno, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of Film Dosage Form Containing Allopurinol for Prevention and Treatment of Oral Mucositis</atitle><jtitle>ISRN pharmaceutics</jtitle><addtitle>ISRN Pharm</addtitle><date>2012</date><risdate>2012</risdate><volume>2012</volume><issue>2012</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>2090-6145</issn><issn>2090-6153</issn><eissn>2090-6153</eissn><abstract>Film dosage forms (FDs) containing allopurinol (AP) were prepared using a casting method with water-soluble polysaccharides, such as sodium alginate (ALG), and the release profile of AP from FDs was investigated in limited dissolution medium. Some ALGs were able to form FDs incorporating AP, and the thickness was about 50 μm. All FDs were easy to handle, though the rheological properties varied with ALG species. AP was homogenously present throughout the FDs and was released with disintegration in 10 mL of physiological saline. These results confirmed that FDs are useful for preventing or treating localized problems in the oral cavity, such as mucositis. FDs are also useful for administering drugs to cancer patients receiving chemotherapy and/or radiotherapy.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>22474608</pmid><doi>10.5402/2012/764510</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2090-6145
ispartof ISRN pharmaceutics, 2012, Vol.2012 (2012), p.1-5
issn 2090-6145
2090-6153
2090-6153
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3317059
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central
title Development of Film Dosage Form Containing Allopurinol for Prevention and Treatment of Oral Mucositis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T04%3A35%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20Film%20Dosage%20Form%20Containing%20Allopurinol%20for%20Prevention%20and%20Treatment%20of%20Oral%20Mucositis&rft.jtitle=ISRN%20pharmaceutics&rft.au=Murata,%20Yoshifumi&rft.date=2012&rft.volume=2012&rft.issue=2012&rft.spage=1&rft.epage=5&rft.pages=1-5&rft.issn=2090-6145&rft.eissn=2090-6153&rft_id=info:doi/10.5402/2012/764510&rft_dat=%3Cproquest_pubme%3E968103320%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=968103320&rft_id=info:pmid/22474608&rfr_iscdi=true