Estrogen negatively regulates epithelial wound healing and protective lipid mediator circuits in the cornea

Estrogen receptors (ERs) are expressed in leukocytes and in every ocular tissue. However, sex‐specific differences and the role of estradiol in ocular inflammatory‐reparative responses are not well understood. We found that female mice exhibited delayed corneal epithelial wound closure and attenuate...

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Veröffentlicht in:	The FASEB journal 2012-04, Vol.26 (4), p.1506-1516
Hauptverfasser:	Wang, Samantha B., Hu, Kyle M., Seamon, Kyle J., Mani, Vinidhra, Chen, Yangdi, Gronert, Karsten
Format:	Artikel
Sprache:	eng
Schlagworte:	15‐LOX 17β‐estradiol Animals Arachidonate 15-Lipoxygenase - metabolism Cell Line Cornea - cytology Cornea - drug effects Cornea - pathology Cornea - physiology Epithelium, Corneal - cytology Epithelium, Corneal - drug effects Epithelium, Corneal - pathology Epithelium, Corneal - physiology ERα ERβ Estrogen Receptor alpha - metabolism Estrogen Receptor beta - metabolism Estrogens - pharmacology Female Humans Leukocytes - cytology Leukocytes - drug effects Leukocytes - physiology Lipid Metabolism - drug effects lipoxin A4 Male Mice Mice, Inbred BALB C Receptors, Formyl Peptide - metabolism Research Communications Sex Characteristics sex‐specific Wound Healing - drug effects Wound Healing - physiology
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