FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis

Clathrin-mediated endocytosis regulates the internalization of many nutrient and signaling receptors. Clathrin and endocytic accessory proteins are recruited to receptors by specific adaptors. The adaptor Disabled-2 (Dab2) recruits its cargoes, including the low-density lipoprotein receptor (LDLR),...

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Veröffentlicht in:	Molecular biology of the cell 2012-04, Vol.23 (7), p.1330-1342
Hauptverfasser:	Mulkearns, Erin E, Cooper, Jonathan A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Protein Complex 2 - antagonists & inhibitors Adaptor Protein Complex 2 - genetics Adaptor Protein Complex 2 - metabolism Adaptor Proteins, Signal Transducing - antagonists & inhibitors Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Base Sequence Cell Line Clathrin-Coated Vesicles - metabolism Endocytosis - physiology HeLa Cells Humans Membrane Proteins Mutagenesis, Site-Directed Mutant Proteins - chemistry Mutant Proteins - genetics Mutant Proteins - metabolism Protein Interaction Domains and Motifs Proteins - antagonists & inhibitors Proteins - chemistry Proteins - genetics Proteins - metabolism Receptors, LDL - metabolism Receptors, Transferrin - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism RNA, Small Interfering - genetics Tumor Suppressor Proteins
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