Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis

Amplification of the MYCN oncogene in childhood neuroblastoma is often accompanied by mutational activation of ALK (anaplastic lymphoma kinase), suggesting their pathogenic cooperation. We generated a transgenic zebrafish model of neuroblastoma in which MYCN-induced tumors arise from a subpopulation...

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Veröffentlicht in:	Cancer cell 2012-03, Vol.21 (3), p.362-373
Hauptverfasser:	Zhu, Shizhen, Lee, Jeong-Soo, Guo, Feng, Shin, Jimann, Perez-Atayde, Antonio R., Kutok, Jeffery L., Rodig, Scott J., Neuberg, Donna S., Helman, Daniel, Feng, Hui, Stewart, Rodney A., Wang, Wenchao, George, Rani E., Kanki, John P., Look, A. Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Disease Models, Animal Humans Molecular Sequence Data N-Myc Proto-Oncogene Protein Neuroblastoma - genetics Neuroblastoma - pathology Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear Proteins - physiology Oncogene Proteins - genetics Oncogene Proteins - metabolism Oncogene Proteins - physiology Organisms, Genetically Modified Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptor Protein-Tyrosine Kinases - physiology Zebrafish - genetics
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