Childhood adversity, serotonin transporter (5-HTTLPR) genotype, and risk for cigarette smoking and nicotine dependence in alcohol dependent adults
Abstract Background This study examined the extent to which cigarette smoking and nicotine dependence in adults with alcohol dependence (AD) are associated with adverse childhood experiences. Gender, social support, and an allelic variant in the gene encoding the serotonin transporter (5-HTTLPR) wer...
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| Veröffentlicht in: | Drug and alcohol dependence 2012-06, Vol.123 (1), p.201-206 |
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| description | Abstract Background This study examined the extent to which cigarette smoking and nicotine dependence in adults with alcohol dependence (AD) are associated with adverse childhood experiences. Gender, social support, and an allelic variant in the gene encoding the serotonin transporter (5-HTTLPR) were examined as moderators of this relationship. Methods The Semi-Structured Assessment for the Genetics of Alcoholism – Version II (SSAGA-II) was used to assess DSM-IV diagnoses and cigarette smoking characteristics as well as traumatic life events and social support during childhood in 256 AD men ( n = 149) and women ( n = 107). Results An increase in number of adverse childhood events was associated with heightened risk of cigarette use and nicotine dependence. 5-HTTLPR genotype, gender, and social support did not significantly moderate the relationships among childhood adversity and ever-smoking or nicotine dependence. Conclusions Results extend previous findings to suggest that childhood adversity is strongly related to risk for ever-smoking and nicotine dependence in AD individuals. Additional research is needed to examine other potential genetic and environmental moderators and mediators of the relationships among smoking, alcohol use, and childhood trauma. |
| doi_str_mv | 10.1016/j.drugalcdep.2011.11.013 |
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Gender, social support, and an allelic variant in the gene encoding the serotonin transporter (5-HTTLPR) were examined as moderators of this relationship. Methods The Semi-Structured Assessment for the Genetics of Alcoholism – Version II (SSAGA-II) was used to assess DSM-IV diagnoses and cigarette smoking characteristics as well as traumatic life events and social support during childhood in 256 AD men ( n = 149) and women ( n = 107). Results An increase in number of adverse childhood events was associated with heightened risk of cigarette use and nicotine dependence. 5-HTTLPR genotype, gender, and social support did not significantly moderate the relationships among childhood adversity and ever-smoking or nicotine dependence. Conclusions Results extend previous findings to suggest that childhood adversity is strongly related to risk for ever-smoking and nicotine dependence in AD individuals. Additional research is needed to examine other potential genetic and environmental moderators and mediators of the relationships among smoking, alcohol use, and childhood trauma.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/j.drugalcdep.2011.11.013</identifier><identifier>PMID: 22172222</identifier><identifier>CODEN: DADEDV</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Addictive behaviors ; Adolescent ; Adult ; Adult and adolescent clinical studies ; Adversity ; Alcohol ; alcoholism ; Alcoholism - epidemiology ; Alcoholism - genetics ; Alcoholism - psychology ; Anxiety Disorders - epidemiology ; Anxiety Disorders - psychology ; Biological and medical sciences ; Child ; Child Abuse - psychology ; Child Abuse, Sexual - psychology ; Childhood ; Children ; Cigarettes ; Drug dependency ; Drugs ; Female ; Gender ; Gene-Environment Interaction ; Genetics ; Genotype ; Genotypes ; Humans ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Mood Disorders - epidemiology ; Mood Disorders - psychology ; Nicotine ; Poverty ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Risk ; Serotonin Plasma Membrane Transport Proteins - genetics ; Sex Factors ; Smoking ; Smoking - epidemiology ; Smoking - genetics ; Smoking - psychology ; Social Support ; Socioeconomic Factors ; Stress, Psychological - genetics ; Stress, Psychological - psychology ; Substance abuse ; Tobacco ; Tobacco smoking ; Tobacco Use Disorder - epidemiology ; Tobacco Use Disorder - genetics ; Tobacco Use Disorder - psychology ; Tobacco, tobacco smoking ; Toxicology ; Trauma ; Victimology ; Violence</subject><ispartof>Drug and alcohol dependence, 2012-06, Vol.123 (1), p.201-206</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><rights>2011 Elsevier Ireland Ltd. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c630t-d1be387a3c2f51e0e154ecb07a84d9f34c7d2cb4e4c2dcc052e03b5c291bda1e3</citedby><cites>FETCH-LOGICAL-c630t-d1be387a3c2f51e0e154ecb07a84d9f34c7d2cb4e4c2dcc052e03b5c291bda1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.drugalcdep.2011.11.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,31000,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25948653$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22172222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mingione, Carolyn J</creatorcontrib><creatorcontrib>Heffner, Jaimee L</creatorcontrib><creatorcontrib>Blom, Thomas J</creatorcontrib><creatorcontrib>Anthenelli, Robert M</creatorcontrib><title>Childhood adversity, serotonin transporter (5-HTTLPR) genotype, and risk for cigarette smoking and nicotine dependence in alcohol dependent adults</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>Abstract Background This study examined the extent to which cigarette smoking and nicotine dependence in adults with alcohol dependence (AD) are associated with adverse childhood experiences. Gender, social support, and an allelic variant in the gene encoding the serotonin transporter (5-HTTLPR) were examined as moderators of this relationship. Methods The Semi-Structured Assessment for the Genetics of Alcoholism – Version II (SSAGA-II) was used to assess DSM-IV diagnoses and cigarette smoking characteristics as well as traumatic life events and social support during childhood in 256 AD men ( n = 149) and women ( n = 107). Results An increase in number of adverse childhood events was associated with heightened risk of cigarette use and nicotine dependence. 5-HTTLPR genotype, gender, and social support did not significantly moderate the relationships among childhood adversity and ever-smoking or nicotine dependence. Conclusions Results extend previous findings to suggest that childhood adversity is strongly related to risk for ever-smoking and nicotine dependence in AD individuals. Additional research is needed to examine other potential genetic and environmental moderators and mediators of the relationships among smoking, alcohol use, and childhood trauma.</description><subject>Addictive behaviors</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Adversity</subject><subject>Alcohol</subject><subject>alcoholism</subject><subject>Alcoholism - epidemiology</subject><subject>Alcoholism - genetics</subject><subject>Alcoholism - psychology</subject><subject>Anxiety Disorders - epidemiology</subject><subject>Anxiety Disorders - psychology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child Abuse - psychology</subject><subject>Child Abuse, Sexual - psychology</subject><subject>Childhood</subject><subject>Children</subject><subject>Cigarettes</subject><subject>Drug dependency</subject><subject>Drugs</subject><subject>Female</subject><subject>Gender</subject><subject>Gene-Environment Interaction</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood Disorders - epidemiology</subject><subject>Mood Disorders - psychology</subject><subject>Nicotine</subject><subject>Poverty</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Risk</subject><subject>Serotonin Plasma Membrane Transport Proteins - genetics</subject><subject>Sex Factors</subject><subject>Smoking</subject><subject>Smoking - epidemiology</subject><subject>Smoking - genetics</subject><subject>Smoking - psychology</subject><subject>Social Support</subject><subject>Socioeconomic Factors</subject><subject>Stress, Psychological - genetics</subject><subject>Stress, Psychological - psychology</subject><subject>Substance abuse</subject><subject>Tobacco</subject><subject>Tobacco smoking</subject><subject>Tobacco Use Disorder - epidemiology</subject><subject>Tobacco Use Disorder - genetics</subject><subject>Tobacco Use Disorder - psychology</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><subject>Trauma</subject><subject>Victimology</subject><subject>Violence</subject><issn>0376-8716</issn><issn>1879-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkt-OEyEUxidG466rr2C4MVmTncqB-XuziTbqmjTRaL0mDJy2tFOowDTpa_jEMrZ21RslBBL4-Pjgd7KMAJ0AherVeqL9sJS90ribMAowSZ0Cf5BdQlO3OaVF9TC7pLyu8qaG6iJ7EsKapla19HF2wRjULLXL7Pt0ZXq9ck4Tqffog4mHGxLQu-issSR6acPO-YieXJf53Xw--_T5JVmidfGwwxsirSbehA1ZOE-UWUqPMSIJW7cxdvlz2xrlorFIUlq0Gq1CkqxTfLdy_Xk1pgRDH8PT7NFC9gGfnear7Ou7t_PpXT77-P7D9PUsVxWnMdfQIW9qyRVblIAUoSxQdbSWTaHbBS9UrZnqCiwU00rRkiHlXalYC52WgPwquz367oZui1qlBF72YufNVvqDcNKIP3esWYml2wvOoawoTwbXJwPvvg0YotiaoLDvpUU3BAHAStZwRut_S2nLi7JKQ5I2R6nyLgSPi3MioGKkL9binr4Y6aebRKKfjj7__UXng79wJ8GLk0AGJftFgqtMuNeVbdFU5Wj05qjD9P97g14EZUZu2nhUUWhn_ifN7V8mqjepFmS_wQOGtRu8TXwFiMAEFV_Gah2LFYDSEqDgPwB2Vut7</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Mingione, Carolyn J</creator><creator>Heffner, Jaimee L</creator><creator>Blom, Thomas J</creator><creator>Anthenelli, Robert M</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7QJ</scope><scope>5PM</scope></search><sort><creationdate>20120601</creationdate><title>Childhood adversity, serotonin transporter (5-HTTLPR) genotype, and risk for cigarette smoking and nicotine dependence in alcohol dependent adults</title><author>Mingione, Carolyn J ; Heffner, Jaimee L ; Blom, Thomas J ; Anthenelli, Robert M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c630t-d1be387a3c2f51e0e154ecb07a84d9f34c7d2cb4e4c2dcc052e03b5c291bda1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Addictive behaviors</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Adversity</topic><topic>Alcohol</topic><topic>alcoholism</topic><topic>Alcoholism - epidemiology</topic><topic>Alcoholism - genetics</topic><topic>Alcoholism - psychology</topic><topic>Anxiety Disorders - epidemiology</topic><topic>Anxiety Disorders - psychology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child Abuse - psychology</topic><topic>Child Abuse, Sexual - psychology</topic><topic>Childhood</topic><topic>Children</topic><topic>Cigarettes</topic><topic>Drug dependency</topic><topic>Drugs</topic><topic>Female</topic><topic>Gender</topic><topic>Gene-Environment Interaction</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood Disorders - epidemiology</topic><topic>Mood Disorders - psychology</topic><topic>Nicotine</topic><topic>Poverty</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Risk</topic><topic>Serotonin Plasma Membrane Transport Proteins - genetics</topic><topic>Sex Factors</topic><topic>Smoking</topic><topic>Smoking - epidemiology</topic><topic>Smoking - genetics</topic><topic>Smoking - psychology</topic><topic>Social Support</topic><topic>Socioeconomic Factors</topic><topic>Stress, Psychological - genetics</topic><topic>Stress, Psychological - psychology</topic><topic>Substance abuse</topic><topic>Tobacco</topic><topic>Tobacco smoking</topic><topic>Tobacco Use Disorder - epidemiology</topic><topic>Tobacco Use Disorder - genetics</topic><topic>Tobacco Use Disorder - psychology</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><topic>Trauma</topic><topic>Victimology</topic><topic>Violence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mingione, Carolyn J</creatorcontrib><creatorcontrib>Heffner, Jaimee L</creatorcontrib><creatorcontrib>Blom, Thomas J</creatorcontrib><creatorcontrib>Anthenelli, Robert M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Drug and alcohol dependence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mingione, Carolyn J</au><au>Heffner, Jaimee L</au><au>Blom, Thomas J</au><au>Anthenelli, Robert M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Childhood adversity, serotonin transporter (5-HTTLPR) genotype, and risk for cigarette smoking and nicotine dependence in alcohol dependent adults</atitle><jtitle>Drug and alcohol dependence</jtitle><addtitle>Drug Alcohol Depend</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>123</volume><issue>1</issue><spage>201</spage><epage>206</epage><pages>201-206</pages><issn>0376-8716</issn><eissn>1879-0046</eissn><coden>DADEDV</coden><abstract>Abstract Background This study examined the extent to which cigarette smoking and nicotine dependence in adults with alcohol dependence (AD) are associated with adverse childhood experiences. Gender, social support, and an allelic variant in the gene encoding the serotonin transporter (5-HTTLPR) were examined as moderators of this relationship. Methods The Semi-Structured Assessment for the Genetics of Alcoholism – Version II (SSAGA-II) was used to assess DSM-IV diagnoses and cigarette smoking characteristics as well as traumatic life events and social support during childhood in 256 AD men ( n = 149) and women ( n = 107). Results An increase in number of adverse childhood events was associated with heightened risk of cigarette use and nicotine dependence. 5-HTTLPR genotype, gender, and social support did not significantly moderate the relationships among childhood adversity and ever-smoking or nicotine dependence. Conclusions Results extend previous findings to suggest that childhood adversity is strongly related to risk for ever-smoking and nicotine dependence in AD individuals. Additional research is needed to examine other potential genetic and environmental moderators and mediators of the relationships among smoking, alcohol use, and childhood trauma.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>22172222</pmid><doi>10.1016/j.drugalcdep.2011.11.013</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Addictive behaviors Adolescent Adult Adult and adolescent clinical studies Adversity Alcohol alcoholism Alcoholism - epidemiology Alcoholism - genetics Alcoholism - psychology Anxiety Disorders - epidemiology Anxiety Disorders - psychology Biological and medical sciences Child Child Abuse - psychology Child Abuse, Sexual - psychology Childhood Children Cigarettes Drug dependency Drugs Female Gender Gene-Environment Interaction Genetics Genotype Genotypes Humans Logistic Models Male Medical sciences Middle Aged Mood Disorders - epidemiology Mood Disorders - psychology Nicotine Poverty Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Serotonin Plasma Membrane Transport Proteins - genetics Sex Factors Smoking Smoking - epidemiology Smoking - genetics Smoking - psychology Social Support Socioeconomic Factors Stress, Psychological - genetics Stress, Psychological - psychology Substance abuse Tobacco Tobacco smoking Tobacco Use Disorder - epidemiology Tobacco Use Disorder - genetics Tobacco Use Disorder - psychology Tobacco, tobacco smoking Toxicology Trauma Victimology Violence |
| title | Childhood adversity, serotonin transporter (5-HTTLPR) genotype, and risk for cigarette smoking and nicotine dependence in alcohol dependent adults |
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