Immunotherapy with IL-10- and IFN-γ-producing CD4 effector cells modulate “Natural” and “Inducible” CD4 TReg cell subpopulation levels: observations in four cases of patients with ovarian cancer

Adoptive T cell therapy for cancer patients optimally requires participation of CD4 T cells. In this phase I/II study, we assessed the therapeutic effects of adoptively transferred IL-10- and IFN-γ-producing CD4 effector cells in patients with recurrent ovarian cancer. Using MUC1 peptide and IL-2 fo...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2012-06, Vol.61 (6), p.839-854
Hauptverfasser:	Dobrzanski, Mark J., Rewers-Felkins, Kathleen A., Samad, Khaliquzzaman A., Quinlin, Imelda S., Phillips, Catherine A., Robinson, William, Dobrzanski, David J., Wright, Stephen E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic agents Biological and medical sciences Cancer Research CD4 antigen Cell number Cell survival Effector cells Female Female genital diseases gamma -Interferon Gynecology. Andrology. Obstetrics Humans Immune response (cell-mediated) Immunological memory Immunology Immunotherapy Interferon-gamma - biosynthesis Interferon-gamma - immunology Interleukin 10 Interleukin 2 Interleukin-10 - immunology Lymphocytes T Medical sciences Medicine Medicine & Public Health Memory cells Middle Aged Mucin-1 - immunology Oncology Original Article Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - immunology Ovarian Neoplasms - therapy Pharmacology. Drug treatments Phenotype T-Lymphocytes, Regulatory - immunology Tumor necrosis factor Tumors
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