MicroRNAs in Patients on Chronic Hemodialysis (MINOS Study)
Diagnosis of acute myocardial injury with biomarkers is difficult in patients with advanced renal failure. Circulating microRNAs are promising new biomarkers of myocardial injury. It is unknown whether levels of microRNAs are affected in patients undergoing hemodialysis. High-sensitivity cardiac tro...
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| Veröffentlicht in: | Clinical journal of the American Society of Nephrology 2012-04, Vol.7 (4), p.619-623 |
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| container_title | Clinical journal of the American Society of Nephrology |
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| creator | Emilian, Cristina Goretti, Emeline Prospert, Fernand Pouthier, Dominique Duhoux, Pierre Gilson, Georges Devaux, Yvan Wagner, Daniel R |
| description | Diagnosis of acute myocardial injury with biomarkers is difficult in patients with advanced renal failure. Circulating microRNAs are promising new biomarkers of myocardial injury. It is unknown whether levels of microRNAs are affected in patients undergoing hemodialysis.
High-sensitivity cardiac troponin T (hsTnT) and cardiac-enriched miR-499 were measured in 41 patients with ESRD undergoing hemodialysis and 41 controls.
Levels of hsTnT and miR-499 were highly elevated in patients with ESRD compared with controls (>80-fold increase; P |
| doi_str_mv | 10.2215/CJN.10471011 |
| format | Article |
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High-sensitivity cardiac troponin T (hsTnT) and cardiac-enriched miR-499 were measured in 41 patients with ESRD undergoing hemodialysis and 41 controls.
Levels of hsTnT and miR-499 were highly elevated in patients with ESRD compared with controls (>80-fold increase; P<0.001). Among patients with ESRD, 98% had positive hsTnT levels and 46% had positive miR-499 levels. Levels of troponins were not affected by hemodialysis. However, miR-499 levels were decreased after hemodialysis (6.5-fold decrease; P=0.002).
Both miR-499 and troponins are elevated in patients with advanced renal failure. However, whereas levels of troponins are unaffected by hemodialysis, this is not the case for miR-499. Therefore, these observations mitigate the potential of miR-499 as a marker of myocardial injury in patients with ESRD.</description><identifier>ISSN: 1555-9041</identifier><identifier>EISSN: 1555-905X</identifier><identifier>DOI: 10.2215/CJN.10471011</identifier><identifier>PMID: 22344502</identifier><language>eng</language><publisher>United States: American Society of Nephrology</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers - blood ; Case-Control Studies ; Female ; Heart Diseases - blood ; Heart Diseases - diagnosis ; Heart Diseases - etiology ; Heart Diseases - genetics ; Humans ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - therapy ; Luxembourg ; Male ; MicroRNAs - blood ; Middle Aged ; Original ; Predictive Value of Tests ; Renal Dialysis - adverse effects ; Reproducibility of Results ; Time Factors ; Troponin T - blood</subject><ispartof>Clinical journal of the American Society of Nephrology, 2012-04, Vol.7 (4), p.619-623</ispartof><rights>Copyright © 2012 by the American Society of Nephrology 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-151b67587ad8ca07619bacb5946a7aa1bb8a012c8760ded9e04c11dadc9e4bb3</citedby><cites>FETCH-LOGICAL-c414t-151b67587ad8ca07619bacb5946a7aa1bb8a012c8760ded9e04c11dadc9e4bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315339/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315339/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22344502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Emilian, Cristina</creatorcontrib><creatorcontrib>Goretti, Emeline</creatorcontrib><creatorcontrib>Prospert, Fernand</creatorcontrib><creatorcontrib>Pouthier, Dominique</creatorcontrib><creatorcontrib>Duhoux, Pierre</creatorcontrib><creatorcontrib>Gilson, Georges</creatorcontrib><creatorcontrib>Devaux, Yvan</creatorcontrib><creatorcontrib>Wagner, Daniel R</creatorcontrib><title>MicroRNAs in Patients on Chronic Hemodialysis (MINOS Study)</title><title>Clinical journal of the American Society of Nephrology</title><addtitle>Clin J Am Soc Nephrol</addtitle><description>Diagnosis of acute myocardial injury with biomarkers is difficult in patients with advanced renal failure. Circulating microRNAs are promising new biomarkers of myocardial injury. It is unknown whether levels of microRNAs are affected in patients undergoing hemodialysis.
High-sensitivity cardiac troponin T (hsTnT) and cardiac-enriched miR-499 were measured in 41 patients with ESRD undergoing hemodialysis and 41 controls.
Levels of hsTnT and miR-499 were highly elevated in patients with ESRD compared with controls (>80-fold increase; P<0.001). Among patients with ESRD, 98% had positive hsTnT levels and 46% had positive miR-499 levels. Levels of troponins were not affected by hemodialysis. However, miR-499 levels were decreased after hemodialysis (6.5-fold decrease; P=0.002).
Both miR-499 and troponins are elevated in patients with advanced renal failure. However, whereas levels of troponins are unaffected by hemodialysis, this is not the case for miR-499. Therefore, these observations mitigate the potential of miR-499 as a marker of myocardial injury in patients with ESRD.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Heart Diseases - blood</subject><subject>Heart Diseases - diagnosis</subject><subject>Heart Diseases - etiology</subject><subject>Heart Diseases - genetics</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Luxembourg</subject><subject>Male</subject><subject>MicroRNAs - blood</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Predictive Value of Tests</subject><subject>Renal Dialysis - adverse effects</subject><subject>Reproducibility of Results</subject><subject>Time Factors</subject><subject>Troponin T - blood</subject><issn>1555-9041</issn><issn>1555-905X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtLxDAQh4Movm-epScf4GqmSdoGQVgWdVf2IerBW5im0Ub6WJuusv-9kX2gpxmYj9_8-Ag5AnoZhiCueg_jS6A8BgqwQXZBCNGRVLxurncOO2TPuQ9KOWeh2CY7Ycg4FzTcJdcjq5v6adx1ga2CR2ytqVoX1FXQy5u6sjrom7LOLBZzZ11wNhqMJ8_BczvL5ucHZOsNC2cOl3OfvNzdvvT6neHkftDrDjuaA287ICCNYpHEmCUaaRyBTFGnQvIIY0RI0wQphDqJI5qZTBrKNUCGmZaGpynbJzeL2OksLU2mfcEGCzVtbInNXNVo1f9LZXP1Xn8pxkAwJn3A6TKgqT9nxrWqtE6bosDK1DOnpGSSJknMPHmxIL0T5xrztv4CVP3aVt62Wtn2-PHfZmt4pdcDJwsgt-_5t22MciUWhcdDpT_QVbHiyvtgPyvLh6g</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Emilian, Cristina</creator><creator>Goretti, Emeline</creator><creator>Prospert, Fernand</creator><creator>Pouthier, Dominique</creator><creator>Duhoux, Pierre</creator><creator>Gilson, Georges</creator><creator>Devaux, Yvan</creator><creator>Wagner, Daniel R</creator><general>American Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120401</creationdate><title>MicroRNAs in Patients on Chronic Hemodialysis (MINOS Study)</title><author>Emilian, Cristina ; Goretti, Emeline ; Prospert, Fernand ; Pouthier, Dominique ; Duhoux, Pierre ; Gilson, Georges ; Devaux, Yvan ; Wagner, Daniel R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-151b67587ad8ca07619bacb5946a7aa1bb8a012c8760ded9e04c11dadc9e4bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Heart Diseases - blood</topic><topic>Heart Diseases - diagnosis</topic><topic>Heart Diseases - etiology</topic><topic>Heart Diseases - genetics</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Luxembourg</topic><topic>Male</topic><topic>MicroRNAs - blood</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Predictive Value of Tests</topic><topic>Renal Dialysis - adverse effects</topic><topic>Reproducibility of Results</topic><topic>Time Factors</topic><topic>Troponin T - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Emilian, Cristina</creatorcontrib><creatorcontrib>Goretti, Emeline</creatorcontrib><creatorcontrib>Prospert, Fernand</creatorcontrib><creatorcontrib>Pouthier, Dominique</creatorcontrib><creatorcontrib>Duhoux, Pierre</creatorcontrib><creatorcontrib>Gilson, Georges</creatorcontrib><creatorcontrib>Devaux, Yvan</creatorcontrib><creatorcontrib>Wagner, Daniel R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical journal of the American Society of Nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Emilian, Cristina</au><au>Goretti, Emeline</au><au>Prospert, Fernand</au><au>Pouthier, Dominique</au><au>Duhoux, Pierre</au><au>Gilson, Georges</au><au>Devaux, Yvan</au><au>Wagner, Daniel R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNAs in Patients on Chronic Hemodialysis (MINOS Study)</atitle><jtitle>Clinical journal of the American Society of Nephrology</jtitle><addtitle>Clin J Am Soc Nephrol</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>7</volume><issue>4</issue><spage>619</spage><epage>623</epage><pages>619-623</pages><issn>1555-9041</issn><eissn>1555-905X</eissn><abstract>Diagnosis of acute myocardial injury with biomarkers is difficult in patients with advanced renal failure. Circulating microRNAs are promising new biomarkers of myocardial injury. It is unknown whether levels of microRNAs are affected in patients undergoing hemodialysis.
High-sensitivity cardiac troponin T (hsTnT) and cardiac-enriched miR-499 were measured in 41 patients with ESRD undergoing hemodialysis and 41 controls.
Levels of hsTnT and miR-499 were highly elevated in patients with ESRD compared with controls (>80-fold increase; P<0.001). Among patients with ESRD, 98% had positive hsTnT levels and 46% had positive miR-499 levels. Levels of troponins were not affected by hemodialysis. However, miR-499 levels were decreased after hemodialysis (6.5-fold decrease; P=0.002).
Both miR-499 and troponins are elevated in patients with advanced renal failure. However, whereas levels of troponins are unaffected by hemodialysis, this is not the case for miR-499. Therefore, these observations mitigate the potential of miR-499 as a marker of myocardial injury in patients with ESRD.</abstract><cop>United States</cop><pub>American Society of Nephrology</pub><pmid>22344502</pmid><doi>10.2215/CJN.10471011</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biomarkers - blood Case-Control Studies Female Heart Diseases - blood Heart Diseases - diagnosis Heart Diseases - etiology Heart Diseases - genetics Humans Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy Luxembourg Male MicroRNAs - blood Middle Aged Original Predictive Value of Tests Renal Dialysis - adverse effects Reproducibility of Results Time Factors Troponin T - blood |
| title | MicroRNAs in Patients on Chronic Hemodialysis (MINOS Study) |
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