MicroRNAs in Patients on Chronic Hemodialysis (MINOS Study)

Diagnosis of acute myocardial injury with biomarkers is difficult in patients with advanced renal failure. Circulating microRNAs are promising new biomarkers of myocardial injury. It is unknown whether levels of microRNAs are affected in patients undergoing hemodialysis. High-sensitivity cardiac tro...

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Veröffentlicht in:	Clinical journal of the American Society of Nephrology 2012-04, Vol.7 (4), p.619-623
Hauptverfasser:	Emilian, Cristina, Goretti, Emeline, Prospert, Fernand, Pouthier, Dominique, Duhoux, Pierre, Gilson, Georges, Devaux, Yvan, Wagner, Daniel R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers - blood Case-Control Studies Female Heart Diseases - blood Heart Diseases - diagnosis Heart Diseases - etiology Heart Diseases - genetics Humans Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy Luxembourg Male MicroRNAs - blood Middle Aged Original Predictive Value of Tests Renal Dialysis - adverse effects Reproducibility of Results Time Factors Troponin T - blood
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Zusammenfassung:	Diagnosis of acute myocardial injury with biomarkers is difficult in patients with advanced renal failure. Circulating microRNAs are promising new biomarkers of myocardial injury. It is unknown whether levels of microRNAs are affected in patients undergoing hemodialysis. High-sensitivity cardiac troponin T (hsTnT) and cardiac-enriched miR-499 were measured in 41 patients with ESRD undergoing hemodialysis and 41 controls. Levels of hsTnT and miR-499 were highly elevated in patients with ESRD compared with controls (>80-fold increase; P
ISSN:	1555-9041 1555-905X
DOI:	10.2215/CJN.10471011