NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease

Oxidative stress has long been considered as a major contributing factor in the pathogenesis of Parkinson's disease. However, molecular sources for reactive oxygen species in Parkinson's disease have not been clearly elucidated. Herein, we sought to investigate whether a superoxide-produci...

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Veröffentlicht in:	Antioxidants & redox signaling 2012-05, Vol.16 (10), p.1033-1045
Hauptverfasser:	Choi, Dong-Hee, Cristóvão, Ana Clara, Guhathakurta, Subhrangshu, Lee, Jongmin, Joh, Tong H, Beal, M Flint, Kim, Yoon-Seong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Death - drug effects Cell Line Cell Nucleus - metabolism Corpus Striatum - metabolism DNA Damage Dopaminergic Neurons - enzymology Dopaminergic Neurons - pathology Gene Expression Gene Silencing Humans NADH, NADPH Oxidoreductases - antagonists & inhibitors NADH, NADPH Oxidoreductases - genetics NADH, NADPH Oxidoreductases - metabolism NADPH Oxidase 1 Original Research Communications Oxidative Stress Oxidopamine - pharmacology Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - pathology Protein Transport rac1 GTP-Binding Protein - antagonists & inhibitors rac1 GTP-Binding Protein - metabolism Rats Reactive Oxygen Species - metabolism
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