Mapping the growth hormone–Stat5b–IGF-I transcriptional circuit

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) exert powerful influences on somatic growth, metabolism, and tissue repair, and have been implicated in aging and carcinogenesis. Since the formulation of the somatomedin hypothesis over 50 years ago, GH and IGF-I have been linked intimate...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2012-04, Vol.23 (4), p.186-193
1. Verfasser:	Rotwein, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Endocrinology & Metabolism Fundamental and applied biological sciences. Psychology Growth Hormone - genetics Growth Hormone - metabolism Humans Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Models, Biological STAT5 Transcription Factor - genetics STAT5 Transcription Factor - metabolism Transcription, Genetic - genetics Vertebrates: endocrinology
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