Hip geometry variation is associated with bone mineralization pathway gene variants: The framingham study

Mineralization of bone matrix is an important process in bone formation; thus defects in mineralization have been implicated in bone mineral density (BMD) and bone structure alterations. Three central regulators of phosphate balance, ALPL, ANKH, and ENPP1, are central in the matrix mineralization pr...

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Veröffentlicht in:	Journal of bone and mineral research 2010-07, Vol.25 (7), p.1564-1571
Hauptverfasser:	Cheung, Ching‐Lung, Livshits, Gregory, Zhou, Yanhua, Meigs, James B, McAteer, Jarred B, Florez, Jose C, Cupples, L Adrienne, Demissie, Serkalem, Kiel, Douglas P, Karasik, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alkaline Phosphatase - genetics ALPL ANKH association Binding Sites - genetics Biological and medical sciences Bone Density bone geometry bone mineral density Calcification, Physiologic - genetics Cohort Studies ENPP1 Female Fundamental and applied biological sciences. Psychology Genotype Hip - anatomy & histology Homeodomain Proteins - genetics Humans Male Middle Aged mineralization Original Osteoporosis - genetics Osteoporosis - physiopathology Phosphate Transport Proteins - genetics Phosphoric Diester Hydrolases - genetics Polymorphism, Single Nucleotide Pyrophosphatases - genetics Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system
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