Environmentally induced epigenetic transgenerational inheritance of phenotype and disease
► Clarification of why environmental epigenetics critical for disease etiology. ► Clarification of why epigenetic transgenerational inheritance critical for disease and evolution. ► Clarification of the molecular mechanism involved in how environmental factors affect phenotype. ► Clarification of ro...
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Veröffentlicht in: | Molecular and cellular endocrinology 2012-05, Vol.354 (1-2), p.3-8 |
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creator | Guerrero-Bosagna, Carlos Skinner, Michael K. |
description | ► Clarification of why environmental epigenetics critical for disease etiology. ► Clarification of why epigenetic transgenerational inheritance critical for disease and evolution. ► Clarification of the molecular mechanism involved in how environmental factors affect phenotype. ► Clarification of role epigenetics in disease etiology and phenotypic variation.
Environmental epigenetics has an important role in regulating phenotype formation or disease etiology. The ability of environmental factors and exposures early in life to alter somatic cell epigenomes and subsequent development is a critical factor in how environment affects biology. Environmental epigenetics provides a molecular mechanism to explain long term effects of environment on the development of altered phenotypes and “emergent” properties, which the “genetic determinism” paradigm cannot. When environmental factors permanently alter the germ line epigenome, then epigenetic transgenerational inheritance of these environmentally altered phenotypes and diseases can occur. This environmental epigenetic transgenerational inheritance of phenotype and disease is reviewed with a systems biology perspective. |
doi_str_mv | 10.1016/j.mce.2011.10.004 |
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Environmental epigenetics has an important role in regulating phenotype formation or disease etiology. The ability of environmental factors and exposures early in life to alter somatic cell epigenomes and subsequent development is a critical factor in how environment affects biology. Environmental epigenetics provides a molecular mechanism to explain long term effects of environment on the development of altered phenotypes and “emergent” properties, which the “genetic determinism” paradigm cannot. When environmental factors permanently alter the germ line epigenome, then epigenetic transgenerational inheritance of these environmentally altered phenotypes and diseases can occur. This environmental epigenetic transgenerational inheritance of phenotype and disease is reviewed with a systems biology perspective.</description><identifier>ISSN: 0303-7207</identifier><identifier>EISSN: 1872-8057</identifier><identifier>DOI: 10.1016/j.mce.2011.10.004</identifier><identifier>PMID: 22020198</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Biology ; Cell Division - genetics ; Cellular ; Development ; Disease - genetics ; Endocrine Disruptors - pharmacology ; Endocrinology ; Environment ; Environmental Exposure ; Environmental exposures ; environmental factors ; Environmental Pollutants - pharmacology ; Epigenesis, Genetic - drug effects ; Epigenetics ; Etiology ; Exposure ; Genetics ; germ cells ; Germ-Line Mutation ; Humans ; Long term effects ; Phenotype ; Reproduction ; somatic cells ; Systems Biology ; Transgenerational</subject><ispartof>Molecular and cellular endocrinology, 2012-05, Vol.354 (1-2), p.3-8</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><rights>2011 Published by Elsevier Ireland Ltd. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c606t-346cbd5eae1dee49d8b4a03ad9a6e8b7d02ecbf6a7c92c01e3eb34c3ce5be0293</citedby><cites>FETCH-LOGICAL-c606t-346cbd5eae1dee49d8b4a03ad9a6e8b7d02ecbf6a7c92c01e3eb34c3ce5be0293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mce.2011.10.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22020198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guerrero-Bosagna, Carlos</creatorcontrib><creatorcontrib>Skinner, Michael K.</creatorcontrib><title>Environmentally induced epigenetic transgenerational inheritance of phenotype and disease</title><title>Molecular and cellular endocrinology</title><addtitle>Mol Cell Endocrinol</addtitle><description>► Clarification of why environmental epigenetics critical for disease etiology. ► Clarification of why epigenetic transgenerational inheritance critical for disease and evolution. ► Clarification of the molecular mechanism involved in how environmental factors affect phenotype. ► Clarification of role epigenetics in disease etiology and phenotypic variation.
Environmental epigenetics has an important role in regulating phenotype formation or disease etiology. The ability of environmental factors and exposures early in life to alter somatic cell epigenomes and subsequent development is a critical factor in how environment affects biology. Environmental epigenetics provides a molecular mechanism to explain long term effects of environment on the development of altered phenotypes and “emergent” properties, which the “genetic determinism” paradigm cannot. When environmental factors permanently alter the germ line epigenome, then epigenetic transgenerational inheritance of these environmentally altered phenotypes and diseases can occur. This environmental epigenetic transgenerational inheritance of phenotype and disease is reviewed with a systems biology perspective.</description><subject>Animals</subject><subject>Biology</subject><subject>Cell Division - genetics</subject><subject>Cellular</subject><subject>Development</subject><subject>Disease - genetics</subject><subject>Endocrine Disruptors - pharmacology</subject><subject>Endocrinology</subject><subject>Environment</subject><subject>Environmental Exposure</subject><subject>Environmental exposures</subject><subject>environmental factors</subject><subject>Environmental Pollutants - pharmacology</subject><subject>Epigenesis, Genetic - drug effects</subject><subject>Epigenetics</subject><subject>Etiology</subject><subject>Exposure</subject><subject>Genetics</subject><subject>germ cells</subject><subject>Germ-Line Mutation</subject><subject>Humans</subject><subject>Long term effects</subject><subject>Phenotype</subject><subject>Reproduction</subject><subject>somatic cells</subject><subject>Systems Biology</subject><subject>Transgenerational</subject><issn>0303-7207</issn><issn>1872-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGO0zAQQC0EYrsLH8AFcuSSMrYTJxESElotC9JKHGAPnKyJPWldJXaw00r9e1x1WcEFTtZ43oxm5jH2isOaA1fvduvJ0FoA5zleA1RP2Iq3jShbqJunbAUSZNkIaC7YZUo7AGhq0T5nF0JAruraFftx4w8uBj-RX3Acj4Xzdm_IFjS7DXlanCmWiD6dgoiLCx7HDG0pugW9oSIMxbwlH5bjTAV6W1iXCBO9YM8GHBO9fHiv2P2nm-_Xn8u7r7dfrj_elUaBWkpZKdPbmpC4Jao62_YVgkTboaK2bywIMv2gsDGdMMBJUi8rIw3VPYHo5BX7cO477_uJrMmLRBz1HN2E8agDOv13xrut3oSDlpILxevc4O1Dgxh-7iktenLJ0Diip7BPmquG16pRQv0fBSE6yG6qjPIzamJIKdLwOBEHfbKndzrb0yd7p69sL9e8_nOVx4rfujLw5gwMGDRuokv6_ltO1QC8ha6FTLw_E5RPfnAUdTKOsifrIplF2-D-McAvJMy3bA</recordid><startdate>20120506</startdate><enddate>20120506</enddate><creator>Guerrero-Bosagna, Carlos</creator><creator>Skinner, Michael K.</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7U5</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20120506</creationdate><title>Environmentally induced epigenetic transgenerational inheritance of phenotype and disease</title><author>Guerrero-Bosagna, Carlos ; Skinner, Michael K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c606t-346cbd5eae1dee49d8b4a03ad9a6e8b7d02ecbf6a7c92c01e3eb34c3ce5be0293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Biology</topic><topic>Cell Division - genetics</topic><topic>Cellular</topic><topic>Development</topic><topic>Disease - genetics</topic><topic>Endocrine Disruptors - pharmacology</topic><topic>Endocrinology</topic><topic>Environment</topic><topic>Environmental Exposure</topic><topic>Environmental exposures</topic><topic>environmental factors</topic><topic>Environmental Pollutants - pharmacology</topic><topic>Epigenesis, Genetic - drug effects</topic><topic>Epigenetics</topic><topic>Etiology</topic><topic>Exposure</topic><topic>Genetics</topic><topic>germ cells</topic><topic>Germ-Line Mutation</topic><topic>Humans</topic><topic>Long term effects</topic><topic>Phenotype</topic><topic>Reproduction</topic><topic>somatic cells</topic><topic>Systems Biology</topic><topic>Transgenerational</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guerrero-Bosagna, Carlos</creatorcontrib><creatorcontrib>Skinner, Michael K.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular and cellular endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guerrero-Bosagna, Carlos</au><au>Skinner, Michael K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmentally induced epigenetic transgenerational inheritance of phenotype and disease</atitle><jtitle>Molecular and cellular endocrinology</jtitle><addtitle>Mol Cell Endocrinol</addtitle><date>2012-05-06</date><risdate>2012</risdate><volume>354</volume><issue>1-2</issue><spage>3</spage><epage>8</epage><pages>3-8</pages><issn>0303-7207</issn><eissn>1872-8057</eissn><abstract>► Clarification of why environmental epigenetics critical for disease etiology. ► Clarification of why epigenetic transgenerational inheritance critical for disease and evolution. ► Clarification of the molecular mechanism involved in how environmental factors affect phenotype. ► Clarification of role epigenetics in disease etiology and phenotypic variation.
Environmental epigenetics has an important role in regulating phenotype formation or disease etiology. The ability of environmental factors and exposures early in life to alter somatic cell epigenomes and subsequent development is a critical factor in how environment affects biology. Environmental epigenetics provides a molecular mechanism to explain long term effects of environment on the development of altered phenotypes and “emergent” properties, which the “genetic determinism” paradigm cannot. When environmental factors permanently alter the germ line epigenome, then epigenetic transgenerational inheritance of these environmentally altered phenotypes and diseases can occur. This environmental epigenetic transgenerational inheritance of phenotype and disease is reviewed with a systems biology perspective.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>22020198</pmid><doi>10.1016/j.mce.2011.10.004</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Biology Cell Division - genetics Cellular Development Disease - genetics Endocrine Disruptors - pharmacology Endocrinology Environment Environmental Exposure Environmental exposures environmental factors Environmental Pollutants - pharmacology Epigenesis, Genetic - drug effects Epigenetics Etiology Exposure Genetics germ cells Germ-Line Mutation Humans Long term effects Phenotype Reproduction somatic cells Systems Biology Transgenerational |
title | Environmentally induced epigenetic transgenerational inheritance of phenotype and disease |
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