Understanding latent tuberculosis: a moving target
Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection. Latently infected persons, of which there are estimated to be approximately 2 billion in the world, represent an enormous reser...
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| Veröffentlicht in: | The Journal of immunology (1950) 2010-07, Vol.185 (1), p.15-22 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 185 |
| creator | Lin, Philana Ling Flynn, Joanne L |
| description | Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection. Latently infected persons, of which there are estimated to be approximately 2 billion in the world, represent an enormous reservoir of potential reactivation TB, which can spread to other people. The immunology of TB is complex and multifaceted. Identifying the immune mechanisms that lead to control of initial infection and prevent reactivation of latent infection is crucial to combating this disease. |
| doi_str_mv | 10.4049/jimmunol.0903856 |
| format | Article |
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Infection with Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection. Latently infected persons, of which there are estimated to be approximately 2 billion in the world, represent an enormous reservoir of potential reactivation TB, which can spread to other people. The immunology of TB is complex and multifaceted. Identifying the immune mechanisms that lead to control of initial infection and prevent reactivation of latent infection is crucial to combating this disease.</description><subject>Adaptive Immunity</subject><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Immunity, Innate</subject><subject>Latent Tuberculosis - diagnosis</subject><subject>Latent Tuberculosis - epidemiology</subject><subject>Latent Tuberculosis - immunology</subject><subject>Latent Tuberculosis - microbiology</subject><subject>Mycobacterium tuberculosis - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkL1PwzAQxS0EoqWwM6FuTCnnc2I7DEio4kuqxEJny3GckiqJi-0g8d-Tqh-CW2649949_Qi5pjBLIc3v1nXb9p1rZpADkxk_IWOaZZBwDvyUjAEQEyq4GJGLENYAwAHTczJCyDgil2OCy660PkTdlXW3mjY62i5OY19Yb_rGhTrcT_W0dd_ba9R-ZeMlOat0E-zVfk_I8vnpY_6aLN5f3uaPi8SknMakFDyVXILUVcmFMZlMLYiCUWRc5AwLKaqCI8dCYwEsq0qJ1kg-dNNYWWQT8rDL3fRFa0szFPO6URtft9r_KKdr9f_S1Z9q5b4VY5TmWT4E3O4DvPvqbYiqrYOxTaM76_qgBBsGWS4HJeyUxrsQvK2OXyioLWl1IK32pAfLzd92R8MBLfsFHol8fA</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Lin, Philana Ling</creator><creator>Flynn, Joanne L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100701</creationdate><title>Understanding latent tuberculosis: a moving target</title><author>Lin, Philana Ling ; Flynn, Joanne L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-d76486808afd67cc584e07b312367932b87fb6262ba2b035fd82ec86205a2fe23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adaptive Immunity</topic><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Immunity, Innate</topic><topic>Latent Tuberculosis - diagnosis</topic><topic>Latent Tuberculosis - epidemiology</topic><topic>Latent Tuberculosis - immunology</topic><topic>Latent Tuberculosis - microbiology</topic><topic>Mycobacterium tuberculosis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Philana Ling</creatorcontrib><creatorcontrib>Flynn, Joanne L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Philana Ling</au><au>Flynn, Joanne L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Understanding latent tuberculosis: a moving target</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>185</volume><issue>1</issue><spage>15</spage><epage>22</epage><pages>15-22</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Tuberculosis (TB) remains a threat to the health of people worldwide. 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| fulltext | fulltext |
| identifier | ISSN: 0022-1767 |
| ispartof | The Journal of immunology (1950), 2010-07, Vol.185 (1), p.15-22 |
| issn | 0022-1767 1550-6606 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3311959 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adaptive Immunity Animals Disease Models, Animal Humans Immunity, Cellular Immunity, Innate Latent Tuberculosis - diagnosis Latent Tuberculosis - epidemiology Latent Tuberculosis - immunology Latent Tuberculosis - microbiology Mycobacterium tuberculosis - immunology |
| title | Understanding latent tuberculosis: a moving target |
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