Optimal mechanical environment of the healing bone fracture/osteotomy
The aim of this paper is to review recent experimental and clinical publications on bone biology with respect to the optimal mechanical environment in the healing process of fractures and osteotomies. The basic postulates of bone fracture healing include static bone compression and immobilisation/fi...
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| Veröffentlicht in: | International orthopaedics 2012-04, Vol.36 (4), p.689-695 |
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| container_title | International orthopaedics |
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| creator | Mavčič, Blaž Antolič, Vane |
| description | The aim of this paper is to review recent experimental and clinical publications on bone biology with respect to the optimal mechanical environment in the healing process of fractures and osteotomies. The basic postulates of bone fracture healing include static bone compression and immobilisation/fixation for three weeks and intermittent dynamic loading treatment afterwards. The optimal mechanical strain should be in the range of 100–2,000 microstrain, depending on the frequency of the strain application, type of bone and location in the bone, age and hormonal status. Higher frequency of mechanical strain application or larger number of repetition cycles result in increased bone mass at the healing fracture site, but only up to a certain limit, values beyond which no additional benefit is observed. Strain application and transition period from non-load-bearing to full load-bearing can be modified by implants allowing dynamisation of compression and generating strains at the fracture healing site in a controlled manner. |
| doi_str_mv | 10.1007/s00264-012-1487-8 |
| format | Article |
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The basic postulates of bone fracture healing include static bone compression and immobilisation/fixation for three weeks and intermittent dynamic loading treatment afterwards. The optimal mechanical strain should be in the range of 100–2,000 microstrain, depending on the frequency of the strain application, type of bone and location in the bone, age and hormonal status. Higher frequency of mechanical strain application or larger number of repetition cycles result in increased bone mass at the healing fracture site, but only up to a certain limit, values beyond which no additional benefit is observed. Strain application and transition period from non-load-bearing to full load-bearing can be modified by implants allowing dynamisation of compression and generating strains at the fracture healing site in a controlled manner.</description><identifier>ISSN: 0341-2695</identifier><identifier>EISSN: 1432-5195</identifier><identifier>DOI: 10.1007/s00264-012-1487-8</identifier><identifier>PMID: 22302177</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adaptation, Physiological ; Fracture Fixation - methods ; Fracture Healing - physiology ; Fractures, Bone - physiopathology ; Humans ; Mechanotransduction, Cellular - physiology ; Medicine ; Medicine & Public Health ; Orthopedics ; Osteocytes - physiology ; Osteotomy ; Review ; Review Article ; Stress, Mechanical ; Weight-Bearing</subject><ispartof>International orthopaedics, 2012-04, Vol.36 (4), p.689-695</ispartof><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-da41f14fb7e912575c45f4be1590f91f3e5b433792f4d272ba25c27329705d983</citedby><cites>FETCH-LOGICAL-c442t-da41f14fb7e912575c45f4be1590f91f3e5b433792f4d272ba25c27329705d983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311788/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311788/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,41467,42536,51297,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22302177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mavčič, Blaž</creatorcontrib><creatorcontrib>Antolič, Vane</creatorcontrib><title>Optimal mechanical environment of the healing bone fracture/osteotomy</title><title>International orthopaedics</title><addtitle>International Orthopaedics (SICOT)</addtitle><addtitle>Int Orthop</addtitle><description>The aim of this paper is to review recent experimental and clinical publications on bone biology with respect to the optimal mechanical environment in the healing process of fractures and osteotomies. The basic postulates of bone fracture healing include static bone compression and immobilisation/fixation for three weeks and intermittent dynamic loading treatment afterwards. The optimal mechanical strain should be in the range of 100–2,000 microstrain, depending on the frequency of the strain application, type of bone and location in the bone, age and hormonal status. Higher frequency of mechanical strain application or larger number of repetition cycles result in increased bone mass at the healing fracture site, but only up to a certain limit, values beyond which no additional benefit is observed. Strain application and transition period from non-load-bearing to full load-bearing can be modified by implants allowing dynamisation of compression and generating strains at the fracture healing site in a controlled manner.</description><subject>Adaptation, Physiological</subject><subject>Fracture Fixation - methods</subject><subject>Fracture Healing - physiology</subject><subject>Fractures, Bone - physiopathology</subject><subject>Humans</subject><subject>Mechanotransduction, Cellular - physiology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Orthopedics</subject><subject>Osteocytes - physiology</subject><subject>Osteotomy</subject><subject>Review</subject><subject>Review Article</subject><subject>Stress, Mechanical</subject><subject>Weight-Bearing</subject><issn>0341-2695</issn><issn>1432-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EglL4ADYoSzahHj_iZIOEEC8JiQ2sLccdt0GJXeykUv-eVIUKNqxsaa6P7xxCLoBeA6VqlihlhcgpsBxEqfLygExAcJZLqOQhmVAuIGdFJU_IaUoflIIqSjgmJ4xxykCpCbl_XfVNZ9qsQ7s0vrHjFf26icF36PssuKxfYrZE0zZ-kdXBY-aisf0QcRZSj6EP3eaMHDnTJjz_Pqfk_eH-7e4pf3l9fL67fcmtEKzP50aAA-FqhRUwqaQV0okaQVbUVeA4ylpwrirmxJwpVhsmLVOcVYrKeVXyKbnZcVdD3eHcjg2jafUqjivEjQ6m0X8nvlnqRVhrzgFUuQVcfQNi-Bww9bprksW2NR7DkDRQoAUvirHFlMAuamNIKaLbfwNUb_XrnX496tdb_XqLv_zdb__ix_cYYLtAGkd-gVF_hCH60dk_1C_2RZDV</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Mavčič, Blaž</creator><creator>Antolič, Vane</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120401</creationdate><title>Optimal mechanical environment of the healing bone fracture/osteotomy</title><author>Mavčič, Blaž ; Antolič, Vane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-da41f14fb7e912575c45f4be1590f91f3e5b433792f4d272ba25c27329705d983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adaptation, Physiological</topic><topic>Fracture Fixation - methods</topic><topic>Fracture Healing - physiology</topic><topic>Fractures, Bone - physiopathology</topic><topic>Humans</topic><topic>Mechanotransduction, Cellular - physiology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Orthopedics</topic><topic>Osteocytes - physiology</topic><topic>Osteotomy</topic><topic>Review</topic><topic>Review Article</topic><topic>Stress, Mechanical</topic><topic>Weight-Bearing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mavčič, Blaž</creatorcontrib><creatorcontrib>Antolič, Vane</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International orthopaedics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mavčič, Blaž</au><au>Antolič, Vane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimal mechanical environment of the healing bone fracture/osteotomy</atitle><jtitle>International orthopaedics</jtitle><stitle>International Orthopaedics (SICOT)</stitle><addtitle>Int Orthop</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>36</volume><issue>4</issue><spage>689</spage><epage>695</epage><pages>689-695</pages><issn>0341-2695</issn><eissn>1432-5195</eissn><abstract>The aim of this paper is to review recent experimental and clinical publications on bone biology with respect to the optimal mechanical environment in the healing process of fractures and osteotomies. The basic postulates of bone fracture healing include static bone compression and immobilisation/fixation for three weeks and intermittent dynamic loading treatment afterwards. The optimal mechanical strain should be in the range of 100–2,000 microstrain, depending on the frequency of the strain application, type of bone and location in the bone, age and hormonal status. Higher frequency of mechanical strain application or larger number of repetition cycles result in increased bone mass at the healing fracture site, but only up to a certain limit, values beyond which no additional benefit is observed. 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| ispartof | International orthopaedics, 2012-04, Vol.36 (4), p.689-695 |
| issn | 0341-2695 1432-5195 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Adaptation, Physiological Fracture Fixation - methods Fracture Healing - physiology Fractures, Bone - physiopathology Humans Mechanotransduction, Cellular - physiology Medicine Medicine & Public Health Orthopedics Osteocytes - physiology Osteotomy Review Review Article Stress, Mechanical Weight-Bearing |
| title | Optimal mechanical environment of the healing bone fracture/osteotomy |
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