Substance P Signaling Controls Mast Cell Activation, Degranulation, and Nociceptive Sensitization in a Rat Fracture Model of Complex Regional Pain Syndrome

Patients with complex regional pain syndrome have increased tryptase in the skin of the affected extremity indicating mast cell (MC) accumulation and degranulation, processes known to be mediated by substance P (SP). The dysregulation of SP release from primary afferent neurons is characteristic of...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2012-04, Vol.116 (4), p.882-895
Hauptverfasser:	LI, Wen-Wu, GUO, Tian-Zhi, LIANG, De-Yong, YUAN SUN, KINGERY, Wade S, CLARK, J. David
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Cell activation Complex Regional Pain Syndromes - metabolism Complex Regional Pain Syndromes - pathology Degranulation Disease Models, Animal Electrical stimuli Fibers Fractures Indoles - pharmacology Limbs Male Mast cells Mast Cells - drug effects Mast Cells - metabolism Medical sciences Nerves Neurokinin NK1 receptors Neurokinin-1 Receptor Antagonists Neurons Nociception - physiology Pain Measurement - drug effects Pain Measurement - methods Pain perception Piperidines - pharmacology Rats Rats, Sprague-Dawley Receptors, Neurokinin-1 - metabolism Sciatic nerve Sensory neurons Skin Substance P Substance P - physiology Tibia Tibial Fractures - metabolism Tryptase
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