Activation of the central melanocortin system contributes to the increased arterial pressure in obese Zucker rats

We have previously demonstrated that leptin-mediated activation of the central nervous system (CNS) melanocortin system reduces appetite and increases sympathetic activity and blood pressure (BP). In the present study we examined whether endogenous melanocortin system activation, independent of lept...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2012-03, Vol.302 (5), p.R561-R567
Hauptverfasser:	do Carmo, Jussara M, da Silva, Alexandre A, Rushing, John S, Hall, John E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Blood pressure Blood Pressure - physiology Brain Central Nervous System - physiology Disease Models, Animal Heart rate Heart Rate - physiology Hypertension - physiopathology Infusions, Intraventricular Insulin - blood Male Melanocortins - physiology Melanocyte-Stimulating Hormones - administration & dosage Melanocyte-Stimulating Hormones - pharmacology Nervous system Neural Control Obesity Obesity - blood Obesity - physiopathology Obesity, Diabetes and Energy Homeostasis Rats Rats, Zucker Receptor, Melanocortin, Type 3 - antagonists & inhibitors Receptor, Melanocortin, Type 3 - drug effects Receptor, Melanocortin, Type 4 - antagonists & inhibitors Receptor, Melanocortin, Type 4 - drug effects Receptors, Leptin - physiology Rodents T cell receptors
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