CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

DNA methylation at HpaII (CmCGG) sites inhibits expression of a human proenkephalin-CAT fusion gene when it is transiently expressed in CV-1 cells or stably expressed in C6-glioma cells. The inhibitory effects of HpaII methylation have been mapped to a site within the human proenkephalin promoter lo...

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Veröffentlicht in:	Nucleic acids research 1990-07, Vol.18 (13), p.3975-3982
Hauptverfasser:	COMB, M, GOODMAN, H. M
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine Base Sequence Biological and medical sciences Cloning, Molecular Cytosine - analogs & derivatives Cytosine - metabolism Deoxyribonuclease HpaII Deoxyribonucleases, Type II Site-Specific - metabolism Dinucleoside Phosphates - metabolism DNA - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enkephalins - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humans Methylation Molecular and cellular biology Molecular genetics Molecular Sequence Data Promoter Regions, Genetic Protein Precursors - genetics Restriction Mapping Transcription Factor AP-2 Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing Tumor Cells, Cultured
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