Complementary Approaches To Gauge the Bioavailability and Distribution of Ingested Berry Polyphenolics
Two different strategies for investigating the likely fate, after ingestion, of natural, bioactive berry constituents (anthocyanins and other non-nutritive flavonoids) are compared. A model of the human gastrointestinal tract (TIM-1) that mimicked the biological environment from the point of swallow...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2012-06, Vol.60 (23), p.5763-5771 |
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| container_end_page | 5771 |
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| container_issue | 23 |
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| container_title | Journal of agricultural and food chemistry |
| container_volume | 60 |
| creator | Lila, Mary Ann Ribnicky, David M Rojo, Leonel E Rojas-Silva, Patricio Oren, Andrew Havenaar, Robert Janle, Elsa M Raskin, Ilya Yousef, Gad G Grace, Mary H |
| description | Two different strategies for investigating the likely fate, after ingestion, of natural, bioactive berry constituents (anthocyanins and other non-nutritive flavonoids) are compared. A model of the human gastrointestinal tract (TIM-1) that mimicked the biological environment from the point of swallowing and ingestion through the duodenum, jejunum, and ileum (but not the colon) was used to monitor the stability and bioaccessibility of anthocyanins from both maqui berry and wild blueberry. TIM-1 revealed that most anthocyanins were bioaccessible between the second and third hours after intake. Alternatively, biolabeled anthocyanins and other flavonoids generated in vitro from berry and grape cell cultures were administered to in vivo (rodent) models, allowing measurement and tracking of the absorption and transport of berry constituents and clearance through the urinary tract and colon. The advantages and limitations of the alternative strategies are considered. |
| doi_str_mv | 10.1021/jf203526h |
| format | Article |
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A model of the human gastrointestinal tract (TIM-1) that mimicked the biological environment from the point of swallowing and ingestion through the duodenum, jejunum, and ileum (but not the colon) was used to monitor the stability and bioaccessibility of anthocyanins from both maqui berry and wild blueberry. TIM-1 revealed that most anthocyanins were bioaccessible between the second and third hours after intake. Alternatively, biolabeled anthocyanins and other flavonoids generated in vitro from berry and grape cell cultures were administered to in vivo (rodent) models, allowing measurement and tracking of the absorption and transport of berry constituents and clearance through the urinary tract and colon. The advantages and limitations of the alternative strategies are considered.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf203526h</identifier><identifier>PMID: 22111523</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Absorption ; Animals ; anthocyanins ; Anthocyanins - analysis ; Anthocyanins - pharmacokinetics ; Aristotelia chilensis ; bioavailability ; Biological and medical sciences ; Biological Availability ; blueberries ; Blueberry Plants - chemistry ; Carbon Isotopes - analysis ; Carbon Isotopes - pharmacokinetics ; cell culture ; Cell Line ; colon ; Computer Simulation ; deglutition ; duodenum ; Feeding. Feeding behavior ; Food industries ; Fruit - chemistry ; Fruit and vegetable industries ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal Tract - drug effects ; Gastrointestinal Tract - metabolism ; grapes ; Humans ; ingestion ; jejunum ; Models, Biological ; Phytochemicals - analysis ; Phytochemicals - pharmacokinetics ; polyphenols ; Polyphenols - analysis ; Polyphenols - pharmacokinetics ; Rats ; rodents ; urinary tract ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitis - chemistry</subject><ispartof>Journal of agricultural and food chemistry, 2012-06, Vol.60 (23), p.5763-5771</ispartof><rights>Copyright © 2011 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a459t-b9ab97f7ca9bf53620a588402197437d5b04cb517accc83afe8cbfa79f1332923</citedby><cites>FETCH-LOGICAL-a459t-b9ab97f7ca9bf53620a588402197437d5b04cb517accc83afe8cbfa79f1332923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf203526h$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf203526h$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,309,310,314,780,784,789,790,885,2765,23930,23931,25140,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25990132$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22111523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lila, Mary Ann</creatorcontrib><creatorcontrib>Ribnicky, David M</creatorcontrib><creatorcontrib>Rojo, Leonel E</creatorcontrib><creatorcontrib>Rojas-Silva, Patricio</creatorcontrib><creatorcontrib>Oren, Andrew</creatorcontrib><creatorcontrib>Havenaar, Robert</creatorcontrib><creatorcontrib>Janle, Elsa M</creatorcontrib><creatorcontrib>Raskin, Ilya</creatorcontrib><creatorcontrib>Yousef, Gad G</creatorcontrib><creatorcontrib>Grace, Mary H</creatorcontrib><title>Complementary Approaches To Gauge the Bioavailability and Distribution of Ingested Berry Polyphenolics</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Two different strategies for investigating the likely fate, after ingestion, of natural, bioactive berry constituents (anthocyanins and other non-nutritive flavonoids) are compared. A model of the human gastrointestinal tract (TIM-1) that mimicked the biological environment from the point of swallowing and ingestion through the duodenum, jejunum, and ileum (but not the colon) was used to monitor the stability and bioaccessibility of anthocyanins from both maqui berry and wild blueberry. TIM-1 revealed that most anthocyanins were bioaccessible between the second and third hours after intake. Alternatively, biolabeled anthocyanins and other flavonoids generated in vitro from berry and grape cell cultures were administered to in vivo (rodent) models, allowing measurement and tracking of the absorption and transport of berry constituents and clearance through the urinary tract and colon. The advantages and limitations of the alternative strategies are considered.</description><subject>Absorption</subject><subject>Animals</subject><subject>anthocyanins</subject><subject>Anthocyanins - analysis</subject><subject>Anthocyanins - pharmacokinetics</subject><subject>Aristotelia chilensis</subject><subject>bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>blueberries</subject><subject>Blueberry Plants - chemistry</subject><subject>Carbon Isotopes - analysis</subject><subject>Carbon Isotopes - pharmacokinetics</subject><subject>cell culture</subject><subject>Cell Line</subject><subject>colon</subject><subject>Computer Simulation</subject><subject>deglutition</subject><subject>duodenum</subject><subject>Feeding. Feeding behavior</subject><subject>Food industries</subject><subject>Fruit - chemistry</subject><subject>Fruit and vegetable industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal Tract - drug effects</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>grapes</subject><subject>Humans</subject><subject>ingestion</subject><subject>jejunum</subject><subject>Models, Biological</subject><subject>Phytochemicals - analysis</subject><subject>Phytochemicals - pharmacokinetics</subject><subject>polyphenols</subject><subject>Polyphenols - analysis</subject><subject>Polyphenols - pharmacokinetics</subject><subject>Rats</subject><subject>rodents</subject><subject>urinary tract</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitis - chemistry</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMFOGzEQhq2qVQmUQ1-g9YUDhy0ee51dXypB2lIkJCoBZ2vs2FlHm_XK3iDl7WsUGlqpJx_mm9_zf4R8BPYFGIeLtedMSD7v3pAZSM4qCdC-JTNWhlUr53BEjnNeM8Za2bD35IhzgAKKGfGLuBl7t3HDhGlHL8cxRbSdy_Qh0mvcrhydOkevQsQnDD2a0IdpR3FY0m8hTymY7RTiQKOnN8PK5ckt6ZVLJepX7Hdj54bYB5s_kHce--xOX94T8vjj-8PiZ3V7d32zuLytsJZqqoxCoxrfWFTGSzHnDGXb1qWGamrRLKVhtTUSGrTWtgK9a63x2CgPQnDFxQn5us8dt2bjlrbUStjrMYVNqacjBv3vZAidXsUnLUQx2UAJON8H2BRzTs4fdoHpZ9n6ILuwn_7-7ED-sVuAsxcAs8XeJxxsyK-cVIqBeL76857zGDWuUmEe7zmDmjGAhkP7moQ263XcpqFY_M9JvwFogZ6m</recordid><startdate>20120613</startdate><enddate>20120613</enddate><creator>Lila, Mary Ann</creator><creator>Ribnicky, David M</creator><creator>Rojo, Leonel E</creator><creator>Rojas-Silva, Patricio</creator><creator>Oren, Andrew</creator><creator>Havenaar, Robert</creator><creator>Janle, Elsa M</creator><creator>Raskin, Ilya</creator><creator>Yousef, Gad G</creator><creator>Grace, Mary H</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20120613</creationdate><title>Complementary Approaches To Gauge the Bioavailability and Distribution of Ingested Berry Polyphenolics</title><author>Lila, Mary Ann ; Ribnicky, David M ; Rojo, Leonel E ; Rojas-Silva, Patricio ; Oren, Andrew ; Havenaar, Robert ; Janle, Elsa M ; Raskin, Ilya ; Yousef, Gad G ; Grace, Mary H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a459t-b9ab97f7ca9bf53620a588402197437d5b04cb517accc83afe8cbfa79f1332923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>anthocyanins</topic><topic>Anthocyanins - analysis</topic><topic>Anthocyanins - pharmacokinetics</topic><topic>Aristotelia chilensis</topic><topic>bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>blueberries</topic><topic>Blueberry Plants - chemistry</topic><topic>Carbon Isotopes - analysis</topic><topic>Carbon Isotopes - pharmacokinetics</topic><topic>cell culture</topic><topic>Cell Line</topic><topic>colon</topic><topic>Computer Simulation</topic><topic>deglutition</topic><topic>duodenum</topic><topic>Feeding. Feeding behavior</topic><topic>Food industries</topic><topic>Fruit - chemistry</topic><topic>Fruit and vegetable industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal Tract - drug effects</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>grapes</topic><topic>Humans</topic><topic>ingestion</topic><topic>jejunum</topic><topic>Models, Biological</topic><topic>Phytochemicals - analysis</topic><topic>Phytochemicals - pharmacokinetics</topic><topic>polyphenols</topic><topic>Polyphenols - analysis</topic><topic>Polyphenols - pharmacokinetics</topic><topic>Rats</topic><topic>rodents</topic><topic>urinary tract</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitis - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lila, Mary Ann</creatorcontrib><creatorcontrib>Ribnicky, David M</creatorcontrib><creatorcontrib>Rojo, Leonel E</creatorcontrib><creatorcontrib>Rojas-Silva, Patricio</creatorcontrib><creatorcontrib>Oren, Andrew</creatorcontrib><creatorcontrib>Havenaar, Robert</creatorcontrib><creatorcontrib>Janle, Elsa M</creatorcontrib><creatorcontrib>Raskin, Ilya</creatorcontrib><creatorcontrib>Yousef, Gad G</creatorcontrib><creatorcontrib>Grace, Mary H</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lila, Mary Ann</au><au>Ribnicky, David M</au><au>Rojo, Leonel E</au><au>Rojas-Silva, Patricio</au><au>Oren, Andrew</au><au>Havenaar, Robert</au><au>Janle, Elsa M</au><au>Raskin, Ilya</au><au>Yousef, Gad G</au><au>Grace, Mary H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complementary Approaches To Gauge the Bioavailability and Distribution of Ingested Berry Polyphenolics</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2012-06-13</date><risdate>2012</risdate><volume>60</volume><issue>23</issue><spage>5763</spage><epage>5771</epage><pages>5763-5771</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Two different strategies for investigating the likely fate, after ingestion, of natural, bioactive berry constituents (anthocyanins and other non-nutritive flavonoids) are compared. A model of the human gastrointestinal tract (TIM-1) that mimicked the biological environment from the point of swallowing and ingestion through the duodenum, jejunum, and ileum (but not the colon) was used to monitor the stability and bioaccessibility of anthocyanins from both maqui berry and wild blueberry. TIM-1 revealed that most anthocyanins were bioaccessible between the second and third hours after intake. Alternatively, biolabeled anthocyanins and other flavonoids generated in vitro from berry and grape cell cultures were administered to in vivo (rodent) models, allowing measurement and tracking of the absorption and transport of berry constituents and clearance through the urinary tract and colon. The advantages and limitations of the alternative strategies are considered.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>22111523</pmid><doi>10.1021/jf203526h</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of agricultural and food chemistry, 2012-06, Vol.60 (23), p.5763-5771 |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Absorption Animals anthocyanins Anthocyanins - analysis Anthocyanins - pharmacokinetics Aristotelia chilensis bioavailability Biological and medical sciences Biological Availability blueberries Blueberry Plants - chemistry Carbon Isotopes - analysis Carbon Isotopes - pharmacokinetics cell culture Cell Line colon Computer Simulation deglutition duodenum Feeding. Feeding behavior Food industries Fruit - chemistry Fruit and vegetable industries Fundamental and applied biological sciences. Psychology Gastrointestinal Tract - drug effects Gastrointestinal Tract - metabolism grapes Humans ingestion jejunum Models, Biological Phytochemicals - analysis Phytochemicals - pharmacokinetics polyphenols Polyphenols - analysis Polyphenols - pharmacokinetics Rats rodents urinary tract Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitis - chemistry |
| title | Complementary Approaches To Gauge the Bioavailability and Distribution of Ingested Berry Polyphenolics |
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