Three genes under different developmental control encode elongation factor 1-α in Xenopus laevis
We have cloned cDNAs encoding two variants of the elongation factor for protein synthesis in Xenopus laevis, called EF-1 alpha. One of these (42Sp50) is expressed exclusively in immature oocytes. It is one of two protein components of a 42S RNP particle that is very abundant in previtellogenic oocyt...
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| Veröffentlicht in: | Nucleic acids research 1990-06, Vol.18 (12), p.3489-3493 |
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| creator | DJE, M. K MAZABRAUD, A VIEL, A LE MAIRE, M DENIS, H CRAWFORD, E BROWN, D. D |
| description | We have cloned cDNAs encoding two variants of the elongation factor for protein synthesis in Xenopus laevis, called EF-1 alpha. One of these (42Sp50) is expressed exclusively in immature oocytes. It is one of two protein components of a 42S RNP particle that is very abundant in previtellogenic oocytes. The 42S RNP particle consists of various tRNAs, 5S RNA, 42Sp50 and a 5S RNA binding protein (42Sp43). A major function served by 42Sp50 appears to be the storage of tRNAs for later use in oogenesis and early embryogenesis. The second EF-1 alpha variant (EF-1 alpha O) is expressed mainly in oocytes but transiently in early embryogenesis as well. Its mRNA cannot be detected after neurulation in somatic cells. EF-1 alpha O is closely related to a third EF-1 alpha (EF-1 alpha S), discovered originally by Krieg et al. (1). EF-1 alpha S is expressed at low levels in oocytes but actively in somatic cells. The latter two proteins are very similar to known eukaryotic EF-1 alpha from other organisms and presumably function in their respective cell types to support protein synthesis. |
| doi_str_mv | 10.1093/nar/18.12.3489 |
| format | Article |
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K ; MAZABRAUD, A ; VIEL, A ; LE MAIRE, M ; DENIS, H ; CRAWFORD, E ; BROWN, D. D</creator><creatorcontrib>DJE, M. K ; MAZABRAUD, A ; VIEL, A ; LE MAIRE, M ; DENIS, H ; CRAWFORD, E ; BROWN, D. D</creatorcontrib><description>We have cloned cDNAs encoding two variants of the elongation factor for protein synthesis in Xenopus laevis, called EF-1 alpha. One of these (42Sp50) is expressed exclusively in immature oocytes. It is one of two protein components of a 42S RNP particle that is very abundant in previtellogenic oocytes. The 42S RNP particle consists of various tRNAs, 5S RNA, 42Sp50 and a 5S RNA binding protein (42Sp43). A major function served by 42Sp50 appears to be the storage of tRNAs for later use in oogenesis and early embryogenesis. The second EF-1 alpha variant (EF-1 alpha O) is expressed mainly in oocytes but transiently in early embryogenesis as well. Its mRNA cannot be detected after neurulation in somatic cells. EF-1 alpha O is closely related to a third EF-1 alpha (EF-1 alpha S), discovered originally by Krieg et al. (1). EF-1 alpha S is expressed at low levels in oocytes but actively in somatic cells. The latter two proteins are very similar to known eukaryotic EF-1 alpha from other organisms and presumably function in their respective cell types to support protein synthesis.</description><identifier>ISSN: 0305-1048</identifier><identifier>EISSN: 1362-4962</identifier><identifier>DOI: 10.1093/nar/18.12.3489</identifier><identifier>PMID: 2362804</identifier><identifier>CODEN: NARHAD</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Biological and medical sciences ; Blotting, Northern ; Cloning, Molecular ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Genes ; Genes. Genome ; Liver - metabolism ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Oocytes - metabolism ; Peptide Elongation Factor 1 ; Peptide Elongation Factors - biosynthesis ; Peptide Elongation Factors - genetics ; Ribonucleoproteins - genetics ; Sequence Homology, Nucleic Acid ; Xenopus laevis</subject><ispartof>Nucleic acids research, 1990-06, Vol.18 (12), p.3489-3493</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-6cbcbe4a0f2d236d9100cdb4f6385ab8eee177e387c3d4942c209e996d8c167c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC331001/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC331001/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19608822$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2362804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DJE, M. K</creatorcontrib><creatorcontrib>MAZABRAUD, A</creatorcontrib><creatorcontrib>VIEL, A</creatorcontrib><creatorcontrib>LE MAIRE, M</creatorcontrib><creatorcontrib>DENIS, H</creatorcontrib><creatorcontrib>CRAWFORD, E</creatorcontrib><creatorcontrib>BROWN, D. D</creatorcontrib><title>Three genes under different developmental control encode elongation factor 1-α in Xenopus laevis</title><title>Nucleic acids research</title><addtitle>Nucleic Acids Res</addtitle><description>We have cloned cDNAs encoding two variants of the elongation factor for protein synthesis in Xenopus laevis, called EF-1 alpha. One of these (42Sp50) is expressed exclusively in immature oocytes. It is one of two protein components of a 42S RNP particle that is very abundant in previtellogenic oocytes. The 42S RNP particle consists of various tRNAs, 5S RNA, 42Sp50 and a 5S RNA binding protein (42Sp43). A major function served by 42Sp50 appears to be the storage of tRNAs for later use in oogenesis and early embryogenesis. The second EF-1 alpha variant (EF-1 alpha O) is expressed mainly in oocytes but transiently in early embryogenesis as well. Its mRNA cannot be detected after neurulation in somatic cells. EF-1 alpha O is closely related to a third EF-1 alpha (EF-1 alpha S), discovered originally by Krieg et al. (1). EF-1 alpha S is expressed at low levels in oocytes but actively in somatic cells. The latter two proteins are very similar to known eukaryotic EF-1 alpha from other organisms and presumably function in their respective cell types to support protein synthesis.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Cloning, Molecular</subject><subject>Fundamental and applied biological sciences. 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D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-6cbcbe4a0f2d236d9100cdb4f6385ab8eee177e387c3d4942c209e996d8c167c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Cloning, Molecular</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Genes</topic><topic>Genes. 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K</au><au>MAZABRAUD, A</au><au>VIEL, A</au><au>LE MAIRE, M</au><au>DENIS, H</au><au>CRAWFORD, E</au><au>BROWN, D. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three genes under different developmental control encode elongation factor 1-α in Xenopus laevis</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucleic Acids Res</addtitle><date>1990-06-25</date><risdate>1990</risdate><volume>18</volume><issue>12</issue><spage>3489</spage><epage>3493</epage><pages>3489-3493</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><coden>NARHAD</coden><abstract>We have cloned cDNAs encoding two variants of the elongation factor for protein synthesis in Xenopus laevis, called EF-1 alpha. One of these (42Sp50) is expressed exclusively in immature oocytes. It is one of two protein components of a 42S RNP particle that is very abundant in previtellogenic oocytes. The 42S RNP particle consists of various tRNAs, 5S RNA, 42Sp50 and a 5S RNA binding protein (42Sp43). A major function served by 42Sp50 appears to be the storage of tRNAs for later use in oogenesis and early embryogenesis. The second EF-1 alpha variant (EF-1 alpha O) is expressed mainly in oocytes but transiently in early embryogenesis as well. Its mRNA cannot be detected after neurulation in somatic cells. EF-1 alpha O is closely related to a third EF-1 alpha (EF-1 alpha S), discovered originally by Krieg et al. (1). EF-1 alpha S is expressed at low levels in oocytes but actively in somatic cells. The latter two proteins are very similar to known eukaryotic EF-1 alpha from other organisms and presumably function in their respective cell types to support protein synthesis.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>2362804</pmid><doi>10.1093/nar/18.12.3489</doi><tpages>5</tpages></addata></record> |
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| ispartof | Nucleic acids research, 1990-06, Vol.18 (12), p.3489-3493 |
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| source | MEDLINE; PubMed Central; Oxford University Press Journals Digital Archive Legacy |
| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences Blotting, Northern Cloning, Molecular Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes Genes. Genome Liver - metabolism Molecular and cellular biology Molecular genetics Molecular Sequence Data Oocytes - metabolism Peptide Elongation Factor 1 Peptide Elongation Factors - biosynthesis Peptide Elongation Factors - genetics Ribonucleoproteins - genetics Sequence Homology, Nucleic Acid Xenopus laevis |
| title | Three genes under different developmental control encode elongation factor 1-α in Xenopus laevis |
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