Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking
The tendency to seek stimulating activities and intense sensations define excitement-seeking, a personality trait akin to some aspects of sensation-seeking. This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct. Those who score high on measures...
Gespeichert in:
| Veröffentlicht in: | Translational psychiatry 2011-10, Vol.1 (10), p.e49-e49 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e49 |
|---|---|
| container_issue | 10 |
| container_start_page | e49 |
| container_title | Translational psychiatry |
| container_volume | 1 |
| creator | Terracciano, A Esko, T Sutin, A R de Moor, M H M Meirelles, O Zhu, G Tanaka, T Giegling, I Nutile, T Realo, A Allik, J Hansell, N K Wright, M J Montgomery, G W Willemsen, G Hottenga, J-J Friedl, M Ruggiero, D Sorice, R Sanna, S Cannas, A Räikkönen, K Widen, E Palotie, A Eriksson, J G Cucca, F Krueger, R F Lahti, J Luciano, M Smoller, J W van Duijn, C M Abecasis, G R Boomsma, D I Ciullo, M Costa, P T Ferrucci, L Martin, N G Metspalu, A Rujescu, D Schlessinger, D Uda, M |
| description | The tendency to seek stimulating activities and intense sensations define excitement-seeking, a personality trait akin to some aspects of sensation-seeking. This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct. Those who score high on measures of excitement-seeking are more likely to smoke, use other drugs, gamble, drive recklessly, have unsafe/unprotected sex and engage in other risky behaviors of clinical and social relevance. To identify common genetic variants associated with the Excitement-Seeking scale of the Revised NEO Personality Inventory, we performed genome-wide association studies in six samples of European ancestry (
N
=7860), and combined the results in a meta-analysis. We identified a genome-wide significant association between the Excitement-Seeking scale and rs7600563 (
P
=2 × 10
−8
). This single-nucleotide polymorphism maps within the
catenin cadherin-associated protein, alpha 2
(
CTNNA2
) gene, which encodes for a brain-expressed α-catenin critical for synaptic contact. The effect of rs7600563 was in the same direction in all six samples, but did not replicate in additional samples (
N
=5105). The results provide insight into the genetics of excitement-seeking and risk-taking, and are relevant to hyperactivity, substance use, antisocial and bipolar disorders. |
| doi_str_mv | 10.1038/tp.2011.42 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3309493</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4067969701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-f60eb5e1cc498aafc6c93896833b955b69c49c43177c7888fbf2694395748b083</originalsourceid><addsrcrecordid>eNplkUtP3DAUha2KqiDKpj-gitQNAmXqZ2JvkNCI0kqUbujacjw3g2liD7bD49_Xo6GjKXjjK5_vnnvki9AngmcEM_k1r2YUEzLj9B06oETImhEp93bqfXSU0h0uR3BJWvIB7VMqGSNKHKCnn5BNbbwZnpNLVeirJfgwQv3oFlCZlIJ1Jrvgq5SnhYNUlXefXb8ubRjHojyY6IzPRfLV_Ob6-pxuG2FRPbp8W8GTdRnG0lkngD_OLz-i970ZEhy93Ifo97eLm_n3-urX5Y_5-VVtOae57hsMnQBiLVfSmN42VjGpmpK_U0J0jSqC5Yy0rW2llH3X00ZxpkTLZYclO0RnG9_V1I2wsCVCNINeRTea-KyDcfp_xbtbvQwPmjGsuGLF4PjFIIb7CVLWo0sWhsF4CFPSZQsYS0wbXtAvr9C7MMXyt4VqFWENoUIU6mRD2RhSitBvwxC8dpM6r_R6p5rTAn_ejb9F_22wAKcbIBXJLyHuzHxr9xfD2Kw1</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1791361255</pqid></control><display><type>article</type><title>Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking</title><source>MEDLINE</source><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Springer Nature OA Free Journals</source><creator>Terracciano, A ; Esko, T ; Sutin, A R ; de Moor, M H M ; Meirelles, O ; Zhu, G ; Tanaka, T ; Giegling, I ; Nutile, T ; Realo, A ; Allik, J ; Hansell, N K ; Wright, M J ; Montgomery, G W ; Willemsen, G ; Hottenga, J-J ; Friedl, M ; Ruggiero, D ; Sorice, R ; Sanna, S ; Cannas, A ; Räikkönen, K ; Widen, E ; Palotie, A ; Eriksson, J G ; Cucca, F ; Krueger, R F ; Lahti, J ; Luciano, M ; Smoller, J W ; van Duijn, C M ; Abecasis, G R ; Boomsma, D I ; Ciullo, M ; Costa, P T ; Ferrucci, L ; Martin, N G ; Metspalu, A ; Rujescu, D ; Schlessinger, D ; Uda, M</creator><creatorcontrib>Terracciano, A ; Esko, T ; Sutin, A R ; de Moor, M H M ; Meirelles, O ; Zhu, G ; Tanaka, T ; Giegling, I ; Nutile, T ; Realo, A ; Allik, J ; Hansell, N K ; Wright, M J ; Montgomery, G W ; Willemsen, G ; Hottenga, J-J ; Friedl, M ; Ruggiero, D ; Sorice, R ; Sanna, S ; Cannas, A ; Räikkönen, K ; Widen, E ; Palotie, A ; Eriksson, J G ; Cucca, F ; Krueger, R F ; Lahti, J ; Luciano, M ; Smoller, J W ; van Duijn, C M ; Abecasis, G R ; Boomsma, D I ; Ciullo, M ; Costa, P T ; Ferrucci, L ; Martin, N G ; Metspalu, A ; Rujescu, D ; Schlessinger, D ; Uda, M</creatorcontrib><description>The tendency to seek stimulating activities and intense sensations define excitement-seeking, a personality trait akin to some aspects of sensation-seeking. This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct. Those who score high on measures of excitement-seeking are more likely to smoke, use other drugs, gamble, drive recklessly, have unsafe/unprotected sex and engage in other risky behaviors of clinical and social relevance. To identify common genetic variants associated with the Excitement-Seeking scale of the Revised NEO Personality Inventory, we performed genome-wide association studies in six samples of European ancestry (
N
=7860), and combined the results in a meta-analysis. We identified a genome-wide significant association between the Excitement-Seeking scale and rs7600563 (
P
=2 × 10
−8
). This single-nucleotide polymorphism maps within the
catenin cadherin-associated protein, alpha 2
(
CTNNA2
) gene, which encodes for a brain-expressed α-catenin critical for synaptic contact. The effect of rs7600563 was in the same direction in all six samples, but did not replicate in additional samples (
N
=5105). The results provide insight into the genetics of excitement-seeking and risk-taking, and are relevant to hyperactivity, substance use, antisocial and bipolar disorders.</description><identifier>ISSN: 2158-3188</identifier><identifier>EISSN: 2158-3188</identifier><identifier>DOI: 10.1038/tp.2011.42</identifier><identifier>PMID: 22833195</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/726/649 ; 631/477 ; 692/699/476 ; Adolescent ; Adult ; alpha Catenin - genetics ; Australia - epidemiology ; Baltimore - epidemiology ; Behavioral Sciences ; Biological Psychology ; Estonia - epidemiology ; Female ; Finland - epidemiology ; Genetic Variation ; Genome-Wide Association Study - methods ; Germany - epidemiology ; Humans ; Italy - epidemiology ; Longitudinal Studies ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Netherlands - epidemiology ; Neurosciences ; Original ; original-article ; Pharmacotherapy ; Polymorphism, Single Nucleotide - genetics ; Psychiatry ; Psychomotor Agitation - classification ; Psychomotor Agitation - genetics ; Psychomotor Agitation - metabolism ; Young Adult</subject><ispartof>Translational psychiatry, 2011-10, Vol.1 (10), p.e49-e49</ispartof><rights>The Author(s) 2011</rights><rights>Copyright Nature Publishing Group Oct 2011</rights><rights>Copyright © 2011 Macmillan Publishers Limited 2011 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-f60eb5e1cc498aafc6c93896833b955b69c49c43177c7888fbf2694395748b083</citedby><cites>FETCH-LOGICAL-c442t-f60eb5e1cc498aafc6c93896833b955b69c49c43177c7888fbf2694395748b083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309493/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309493/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22833195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Terracciano, A</creatorcontrib><creatorcontrib>Esko, T</creatorcontrib><creatorcontrib>Sutin, A R</creatorcontrib><creatorcontrib>de Moor, M H M</creatorcontrib><creatorcontrib>Meirelles, O</creatorcontrib><creatorcontrib>Zhu, G</creatorcontrib><creatorcontrib>Tanaka, T</creatorcontrib><creatorcontrib>Giegling, I</creatorcontrib><creatorcontrib>Nutile, T</creatorcontrib><creatorcontrib>Realo, A</creatorcontrib><creatorcontrib>Allik, J</creatorcontrib><creatorcontrib>Hansell, N K</creatorcontrib><creatorcontrib>Wright, M J</creatorcontrib><creatorcontrib>Montgomery, G W</creatorcontrib><creatorcontrib>Willemsen, G</creatorcontrib><creatorcontrib>Hottenga, J-J</creatorcontrib><creatorcontrib>Friedl, M</creatorcontrib><creatorcontrib>Ruggiero, D</creatorcontrib><creatorcontrib>Sorice, R</creatorcontrib><creatorcontrib>Sanna, S</creatorcontrib><creatorcontrib>Cannas, A</creatorcontrib><creatorcontrib>Räikkönen, K</creatorcontrib><creatorcontrib>Widen, E</creatorcontrib><creatorcontrib>Palotie, A</creatorcontrib><creatorcontrib>Eriksson, J G</creatorcontrib><creatorcontrib>Cucca, F</creatorcontrib><creatorcontrib>Krueger, R F</creatorcontrib><creatorcontrib>Lahti, J</creatorcontrib><creatorcontrib>Luciano, M</creatorcontrib><creatorcontrib>Smoller, J W</creatorcontrib><creatorcontrib>van Duijn, C M</creatorcontrib><creatorcontrib>Abecasis, G R</creatorcontrib><creatorcontrib>Boomsma, D I</creatorcontrib><creatorcontrib>Ciullo, M</creatorcontrib><creatorcontrib>Costa, P T</creatorcontrib><creatorcontrib>Ferrucci, L</creatorcontrib><creatorcontrib>Martin, N G</creatorcontrib><creatorcontrib>Metspalu, A</creatorcontrib><creatorcontrib>Rujescu, D</creatorcontrib><creatorcontrib>Schlessinger, D</creatorcontrib><creatorcontrib>Uda, M</creatorcontrib><title>Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking</title><title>Translational psychiatry</title><addtitle>Transl Psychiatry</addtitle><addtitle>Transl Psychiatry</addtitle><description>The tendency to seek stimulating activities and intense sensations define excitement-seeking, a personality trait akin to some aspects of sensation-seeking. This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct. Those who score high on measures of excitement-seeking are more likely to smoke, use other drugs, gamble, drive recklessly, have unsafe/unprotected sex and engage in other risky behaviors of clinical and social relevance. To identify common genetic variants associated with the Excitement-Seeking scale of the Revised NEO Personality Inventory, we performed genome-wide association studies in six samples of European ancestry (
N
=7860), and combined the results in a meta-analysis. We identified a genome-wide significant association between the Excitement-Seeking scale and rs7600563 (
P
=2 × 10
−8
). This single-nucleotide polymorphism maps within the
catenin cadherin-associated protein, alpha 2
(
CTNNA2
) gene, which encodes for a brain-expressed α-catenin critical for synaptic contact. The effect of rs7600563 was in the same direction in all six samples, but did not replicate in additional samples (
N
=5105). The results provide insight into the genetics of excitement-seeking and risk-taking, and are relevant to hyperactivity, substance use, antisocial and bipolar disorders.</description><subject>631/208/726/649</subject><subject>631/477</subject><subject>692/699/476</subject><subject>Adolescent</subject><subject>Adult</subject><subject>alpha Catenin - genetics</subject><subject>Australia - epidemiology</subject><subject>Baltimore - epidemiology</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Estonia - epidemiology</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Genetic Variation</subject><subject>Genome-Wide Association Study - methods</subject><subject>Germany - epidemiology</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Netherlands - epidemiology</subject><subject>Neurosciences</subject><subject>Original</subject><subject>original-article</subject><subject>Pharmacotherapy</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Psychiatry</subject><subject>Psychomotor Agitation - classification</subject><subject>Psychomotor Agitation - genetics</subject><subject>Psychomotor Agitation - metabolism</subject><subject>Young Adult</subject><issn>2158-3188</issn><issn>2158-3188</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkUtP3DAUha2KqiDKpj-gitQNAmXqZ2JvkNCI0kqUbujacjw3g2liD7bD49_Xo6GjKXjjK5_vnnvki9AngmcEM_k1r2YUEzLj9B06oETImhEp93bqfXSU0h0uR3BJWvIB7VMqGSNKHKCnn5BNbbwZnpNLVeirJfgwQv3oFlCZlIJ1Jrvgq5SnhYNUlXefXb8ubRjHojyY6IzPRfLV_Ob6-pxuG2FRPbp8W8GTdRnG0lkngD_OLz-i970ZEhy93Ifo97eLm_n3-urX5Y_5-VVtOae57hsMnQBiLVfSmN42VjGpmpK_U0J0jSqC5Yy0rW2llH3X00ZxpkTLZYclO0RnG9_V1I2wsCVCNINeRTea-KyDcfp_xbtbvQwPmjGsuGLF4PjFIIb7CVLWo0sWhsF4CFPSZQsYS0wbXtAvr9C7MMXyt4VqFWENoUIU6mRD2RhSitBvwxC8dpM6r_R6p5rTAn_ejb9F_22wAKcbIBXJLyHuzHxr9xfD2Kw1</recordid><startdate>20111018</startdate><enddate>20111018</enddate><creator>Terracciano, A</creator><creator>Esko, T</creator><creator>Sutin, A R</creator><creator>de Moor, M H M</creator><creator>Meirelles, O</creator><creator>Zhu, G</creator><creator>Tanaka, T</creator><creator>Giegling, I</creator><creator>Nutile, T</creator><creator>Realo, A</creator><creator>Allik, J</creator><creator>Hansell, N K</creator><creator>Wright, M J</creator><creator>Montgomery, G W</creator><creator>Willemsen, G</creator><creator>Hottenga, J-J</creator><creator>Friedl, M</creator><creator>Ruggiero, D</creator><creator>Sorice, R</creator><creator>Sanna, S</creator><creator>Cannas, A</creator><creator>Räikkönen, K</creator><creator>Widen, E</creator><creator>Palotie, A</creator><creator>Eriksson, J G</creator><creator>Cucca, F</creator><creator>Krueger, R F</creator><creator>Lahti, J</creator><creator>Luciano, M</creator><creator>Smoller, J W</creator><creator>van Duijn, C M</creator><creator>Abecasis, G R</creator><creator>Boomsma, D I</creator><creator>Ciullo, M</creator><creator>Costa, P T</creator><creator>Ferrucci, L</creator><creator>Martin, N G</creator><creator>Metspalu, A</creator><creator>Rujescu, D</creator><creator>Schlessinger, D</creator><creator>Uda, M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111018</creationdate><title>Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking</title><author>Terracciano, A ; Esko, T ; Sutin, A R ; de Moor, M H M ; Meirelles, O ; Zhu, G ; Tanaka, T ; Giegling, I ; Nutile, T ; Realo, A ; Allik, J ; Hansell, N K ; Wright, M J ; Montgomery, G W ; Willemsen, G ; Hottenga, J-J ; Friedl, M ; Ruggiero, D ; Sorice, R ; Sanna, S ; Cannas, A ; Räikkönen, K ; Widen, E ; Palotie, A ; Eriksson, J G ; Cucca, F ; Krueger, R F ; Lahti, J ; Luciano, M ; Smoller, J W ; van Duijn, C M ; Abecasis, G R ; Boomsma, D I ; Ciullo, M ; Costa, P T ; Ferrucci, L ; Martin, N G ; Metspalu, A ; Rujescu, D ; Schlessinger, D ; Uda, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-f60eb5e1cc498aafc6c93896833b955b69c49c43177c7888fbf2694395748b083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>631/208/726/649</topic><topic>631/477</topic><topic>692/699/476</topic><topic>Adolescent</topic><topic>Adult</topic><topic>alpha Catenin - genetics</topic><topic>Australia - epidemiology</topic><topic>Baltimore - epidemiology</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Estonia - epidemiology</topic><topic>Female</topic><topic>Finland - epidemiology</topic><topic>Genetic Variation</topic><topic>Genome-Wide Association Study - methods</topic><topic>Germany - epidemiology</topic><topic>Humans</topic><topic>Italy - epidemiology</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Netherlands - epidemiology</topic><topic>Neurosciences</topic><topic>Original</topic><topic>original-article</topic><topic>Pharmacotherapy</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Psychiatry</topic><topic>Psychomotor Agitation - classification</topic><topic>Psychomotor Agitation - genetics</topic><topic>Psychomotor Agitation - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Terracciano, A</creatorcontrib><creatorcontrib>Esko, T</creatorcontrib><creatorcontrib>Sutin, A R</creatorcontrib><creatorcontrib>de Moor, M H M</creatorcontrib><creatorcontrib>Meirelles, O</creatorcontrib><creatorcontrib>Zhu, G</creatorcontrib><creatorcontrib>Tanaka, T</creatorcontrib><creatorcontrib>Giegling, I</creatorcontrib><creatorcontrib>Nutile, T</creatorcontrib><creatorcontrib>Realo, A</creatorcontrib><creatorcontrib>Allik, J</creatorcontrib><creatorcontrib>Hansell, N K</creatorcontrib><creatorcontrib>Wright, M J</creatorcontrib><creatorcontrib>Montgomery, G W</creatorcontrib><creatorcontrib>Willemsen, G</creatorcontrib><creatorcontrib>Hottenga, J-J</creatorcontrib><creatorcontrib>Friedl, M</creatorcontrib><creatorcontrib>Ruggiero, D</creatorcontrib><creatorcontrib>Sorice, R</creatorcontrib><creatorcontrib>Sanna, S</creatorcontrib><creatorcontrib>Cannas, A</creatorcontrib><creatorcontrib>Räikkönen, K</creatorcontrib><creatorcontrib>Widen, E</creatorcontrib><creatorcontrib>Palotie, A</creatorcontrib><creatorcontrib>Eriksson, J G</creatorcontrib><creatorcontrib>Cucca, F</creatorcontrib><creatorcontrib>Krueger, R F</creatorcontrib><creatorcontrib>Lahti, J</creatorcontrib><creatorcontrib>Luciano, M</creatorcontrib><creatorcontrib>Smoller, J W</creatorcontrib><creatorcontrib>van Duijn, C M</creatorcontrib><creatorcontrib>Abecasis, G R</creatorcontrib><creatorcontrib>Boomsma, D I</creatorcontrib><creatorcontrib>Ciullo, M</creatorcontrib><creatorcontrib>Costa, P T</creatorcontrib><creatorcontrib>Ferrucci, L</creatorcontrib><creatorcontrib>Martin, N G</creatorcontrib><creatorcontrib>Metspalu, A</creatorcontrib><creatorcontrib>Rujescu, D</creatorcontrib><creatorcontrib>Schlessinger, D</creatorcontrib><creatorcontrib>Uda, M</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Terracciano, A</au><au>Esko, T</au><au>Sutin, A R</au><au>de Moor, M H M</au><au>Meirelles, O</au><au>Zhu, G</au><au>Tanaka, T</au><au>Giegling, I</au><au>Nutile, T</au><au>Realo, A</au><au>Allik, J</au><au>Hansell, N K</au><au>Wright, M J</au><au>Montgomery, G W</au><au>Willemsen, G</au><au>Hottenga, J-J</au><au>Friedl, M</au><au>Ruggiero, D</au><au>Sorice, R</au><au>Sanna, S</au><au>Cannas, A</au><au>Räikkönen, K</au><au>Widen, E</au><au>Palotie, A</au><au>Eriksson, J G</au><au>Cucca, F</au><au>Krueger, R F</au><au>Lahti, J</au><au>Luciano, M</au><au>Smoller, J W</au><au>van Duijn, C M</au><au>Abecasis, G R</au><au>Boomsma, D I</au><au>Ciullo, M</au><au>Costa, P T</au><au>Ferrucci, L</au><au>Martin, N G</au><au>Metspalu, A</au><au>Rujescu, D</au><au>Schlessinger, D</au><au>Uda, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking</atitle><jtitle>Translational psychiatry</jtitle><stitle>Transl Psychiatry</stitle><addtitle>Transl Psychiatry</addtitle><date>2011-10-18</date><risdate>2011</risdate><volume>1</volume><issue>10</issue><spage>e49</spage><epage>e49</epage><pages>e49-e49</pages><issn>2158-3188</issn><eissn>2158-3188</eissn><abstract>The tendency to seek stimulating activities and intense sensations define excitement-seeking, a personality trait akin to some aspects of sensation-seeking. This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct. Those who score high on measures of excitement-seeking are more likely to smoke, use other drugs, gamble, drive recklessly, have unsafe/unprotected sex and engage in other risky behaviors of clinical and social relevance. To identify common genetic variants associated with the Excitement-Seeking scale of the Revised NEO Personality Inventory, we performed genome-wide association studies in six samples of European ancestry (
N
=7860), and combined the results in a meta-analysis. We identified a genome-wide significant association between the Excitement-Seeking scale and rs7600563 (
P
=2 × 10
−8
). This single-nucleotide polymorphism maps within the
catenin cadherin-associated protein, alpha 2
(
CTNNA2
) gene, which encodes for a brain-expressed α-catenin critical for synaptic contact. The effect of rs7600563 was in the same direction in all six samples, but did not replicate in additional samples (
N
=5105). The results provide insight into the genetics of excitement-seeking and risk-taking, and are relevant to hyperactivity, substance use, antisocial and bipolar disorders.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22833195</pmid><doi>10.1038/tp.2011.42</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2158-3188 |
| ispartof | Translational psychiatry, 2011-10, Vol.1 (10), p.e49-e49 |
| issn | 2158-3188 2158-3188 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3309493 |
| source | MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Springer Nature OA Free Journals |
| subjects | 631/208/726/649 631/477 692/699/476 Adolescent Adult alpha Catenin - genetics Australia - epidemiology Baltimore - epidemiology Behavioral Sciences Biological Psychology Estonia - epidemiology Female Finland - epidemiology Genetic Variation Genome-Wide Association Study - methods Germany - epidemiology Humans Italy - epidemiology Longitudinal Studies Male Medicine Medicine & Public Health Middle Aged Netherlands - epidemiology Neurosciences Original original-article Pharmacotherapy Polymorphism, Single Nucleotide - genetics Psychiatry Psychomotor Agitation - classification Psychomotor Agitation - genetics Psychomotor Agitation - metabolism Young Adult |
| title | Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T21%3A01%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Meta-analysis%20of%20genome-wide%20association%20studies%20identifies%20common%20variants%20in%20CTNNA2%20associated%20with%20excitement-seeking&rft.jtitle=Translational%20psychiatry&rft.au=Terracciano,%20A&rft.date=2011-10-18&rft.volume=1&rft.issue=10&rft.spage=e49&rft.epage=e49&rft.pages=e49-e49&rft.issn=2158-3188&rft.eissn=2158-3188&rft_id=info:doi/10.1038/tp.2011.42&rft_dat=%3Cproquest_pubme%3E4067969701%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1791361255&rft_id=info:pmid/22833195&rfr_iscdi=true |