Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug

Plasmodium parasites undergo a clinically silent and obligatory developmental phase in the host's liver cells before they are able to infect erythrocytes and cause malaria symptoms. To overcome the scarcity of compounds targeting the liver stage of malaria, we screened a library of 1037 existin...

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Veröffentlicht in:	The Journal of infectious diseases 2012-04, Vol.205 (8), p.1278-1286
Hauptverfasser:	da Cruz, Filipa P., Martin, Cécilie, Buchholz, Kathrin, Lafuente-Monasterio, Maria J., Rodrigues, Tiago, Sönnichsen, Birte, Moreira, Rui, Gamo, Francisco-Javier, Marti, Matthias, Mota, Maria M., Hannus, Michael, Prudêncio, Miguel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials Antimalarials - pharmacology Atovaquone - pharmacology Biological and medical sciences Blood Cell Line, Tumor Cell lines Cytochromes Decoquinate - pharmacology Drug Evaluation, Preclinical - methods Fundamental and applied biological sciences. Psychology Hepatocytes - parasitology Humans Infections Infectious diseases Inhibitory concentration 50 Liver Major and Brief Reports Malaria Malaria - drug therapy Malaria - parasitology Medical sciences Microbiology Mitochondria - drug effects Mitochondria - metabolism Models, Molecular Molecular Structure Parasites Plasmodium - drug effects Preclinical drug evaluation Protein Conformation
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