Transforming Growth Factor-β1-induced Transcript 1 Protein, a Novel Marker for Smooth Muscle Contractile Phenotype, Is Regulated by Serum Response Factor/Myocardin Protein

Serum response factor (SRF) plays a central role in regulating expression of smooth muscle-specific genes partly by associating with the potent tissue-specific cofactor myocardin. Previous studies have shown that transforming growth factor-β1-induced transcript 1 (TGFB1I1, also known as Hic-5) is a...

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Veröffentlicht in:	The Journal of biological chemistry 2011-12, Vol.286 (48), p.41589-41599
Hauptverfasser:	Wang, Xiaobo, Hu, Guoqing, Betts, Courtney, Harmon, Erin Yund, Keller, Rebecca S., Van De Water, Livingston, Zhou, Jiliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation - biosynthesis Antigens, Differentiation - genetics Cell Proliferation Chlorocebus aethiops COS Cells Cytoskeletal Proteins - biosynthesis Cytoskeletal Proteins - genetics DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Gene Expression Regulation - physiology Gene Regulation HEK293 Cells Hic-5 Humans Intracellular Signaling Peptides and Proteins - genetics LIM Domain Proteins - biosynthesis LIM Domain Proteins - genetics Mice Muscle Contraction - physiology Muscle, Smooth - cytology Muscle, Smooth - metabolism Myocardin Nuclear Proteins - genetics Nuclear Proteins - metabolism Phenotypic Modulation Rats Response Elements - physiology Serum Response Factor Smooth Muscle Smooth Muscle Cell Differentiation Trans-Activators - genetics Trans-Activators - metabolism Transcription Transcription Promoter Transcription Regulation Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Transforming Growth Factor-β (TGF-β)
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