Extremely Conserved ATP- or ADP-dependent Enzymatic System for Nicotinamide Nucleotide Repair

The reduced forms of NAD and NADP, two major nucleotides playing a central role in metabolism, are continuously damaged by enzymatic or heat-dependent hydration. We report the molecular identification of the eukaryotic dehydratase that repairs these nucleotides and show that this enzyme (Carkd in ma...

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Veröffentlicht in:	The Journal of biological chemistry 2011-12, Vol.286 (48), p.41246-41252
Hauptverfasser:	Marbaix, Alexandre Y., Noël, Gaëtane, Detroux, Aline M., Vertommen, Didier, Van Schaftingen, Emile, Linster, Carole L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - chemistry Adenosine Diphosphate - genetics Adenosine Diphosphate - metabolism Adenosine Triphosphate - chemistry Adenosine Triphosphate - genetics Adenosine Triphosphate - metabolism Animals Enzyme Kinetics Enzyme Purification Enzymes Enzymology Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Hydro-Lyases - chemistry Hydro-Lyases - genetics Hydro-Lyases - metabolism Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Metabolism Mice NAD - analogs & derivatives NAD - chemistry NAD - genetics NAD - metabolism NADH NADP - chemistry NADP - genetics NADP - metabolism Protein Structure, Tertiary Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Homology, Amino Acid
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