High Affinity Neurexin Binding to Cell Adhesion G-protein-coupled Receptor CIRL1/Latrophilin-1 Produces an Intercellular Adhesion Complex

The G-protein-coupled receptor CIRL1/latrophilin-1 (CL1) and the type-1 membrane proteins neurexins represent distinct neuronal cell adhesion molecules that exhibit no similarities except for one common function: both proteins are receptors for α-latrotoxin, a component of black widow spider venom t...

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Veröffentlicht in:	The Journal of biological chemistry 2012-03, Vol.287 (12), p.9399-9413
Hauptverfasser:	Boucard, Antony A., Ko, Jaewon, Südhof, Thomas C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autism Cell Adhesion Cell Adhesion Molecules, Neuronal - genetics Cell Adhesion Molecules, Neuronal - metabolism Cell Line Cell Surface Receptor G-protein-coupled Receptors (GPCR) Humans Kinetics Neurobiology Neurological Diseases Neuroscience Neurotoxin Protein Binding Protein Structure, Tertiary Protein/Protein Interactions Rats Receptor Structure-Function Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, G-Protein-Coupled - classification Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Peptide - classification Receptors, Peptide - genetics Receptors, Peptide - metabolism Synapses
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