Organ-specific Sulfation Patterns of Heparan Sulfate Generated by Extracellular Sulfatases Sulf1 and Sulf2 in Mice

Heparan sulfate endosulfatases Sulf1 and Sulf2 hydrolyze 6-O-sulfate in heparan sulfate, thereby regulating cellular signaling. Previous studies have revealed that Sulfs act predominantly on UA2S-GlcNS6S disaccharides and weakly on UA-GlcNS6S disaccharides. However, the specificity of Sulfs and thei...

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Veröffentlicht in:	The Journal of biological chemistry 2012-03, Vol.287 (12), p.9579-9590
Hauptverfasser:	Nagamine, Satoshi, Tamba, Michiko, Ishimine, Hisako, Araki, Kota, Shiomi, Kensuke, Okada, Takuya, Ohto, Tatsuyuki, Kunita, Satoshi, Takahashi, Satoru, Wismans, Ronnie G.P., van Kuppevelt, Toin H., Masu, Masayuki, Keino-Masu, Kazuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - enzymology Brain - metabolism Carbohydrate Biosynthesis Carbohydrate Structure Disaccharide Enzymes Extracellular Space - enzymology Extracellular Space - genetics Gene Knockout Glycobiology Glycobiology and Extracellular Matrices Heparan Sulfate Heparitin Sulfate - chemistry Heparitin Sulfate - metabolism Kidney - enzymology Kidney - metabolism Lung - enzymology Lung - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Molecular Structure Mouse Muscle, Skeletal - enzymology Muscle, Skeletal - metabolism Organ Specificity Proteins - genetics Proteins - metabolism Sulfatase Sulfation Sulfotransferases - genetics Sulfotransferases - metabolism
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