Abundance of Circulating Preadipocyte Factor 1 in Early Life
OBJECTIVE: Soluble preadipocyte factor 1 (Pref-1) inhibits adipocyte differentiation. We tested whether circulating levels of soluble Pref-1 are higher in smaller fetuses. RESEARCH DESIGN AND METHODS: We performed longitudinal assessments of circulating Pref-1 in infants born appropriate for gestati...
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| Veröffentlicht in: | Diabetes care 2012-04, Vol.35 (4), p.848-849 |
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| creator | de Zegher, Francis Díaz, Marta Sebastiani, Giorgia Martín-Ancel, Ana Sánchez-Infantes, David López-Bermejo, Abel Ibáñez, Lourdes |
| description | OBJECTIVE: Soluble preadipocyte factor 1 (Pref-1) inhibits adipocyte differentiation. We tested whether circulating levels of soluble Pref-1 are higher in smaller fetuses. RESEARCH DESIGN AND METHODS: We performed longitudinal assessments of circulating Pref-1 in infants born appropriate for gestational age (AGA) or small for gestational age (SGA) and also in late-gestational women and in newborns on days 2 and 3. RESULTS: At birth, Pref-1 levels were approximately 100-fold higher than in adults, being in SGA fetuses approximately 50% higher than in AGA fetuses. By age 4 months, Pref-1 had reached near-adult levels and the original AGA versus SGA difference had disappeared. Pref-1 levels were low in late-gestational women and were still elevated in newborns. CONCLUSIONS: Pref-1 is abundantly present in the fetus, is higher in SGA than in AGA fetuses, and is likely to be of fetal origin. We speculate that Pref-1 in early life contributes to variation in postnatal adipocyte numbers, in the subsequent expandability of adipose tissue, and thus in the susceptibility to diabetes in later life. |
| doi_str_mv | 10.2337/dc11-1990 |
| format | Article |
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We tested whether circulating levels of soluble Pref-1 are higher in smaller fetuses. RESEARCH DESIGN AND METHODS: We performed longitudinal assessments of circulating Pref-1 in infants born appropriate for gestational age (AGA) or small for gestational age (SGA) and also in late-gestational women and in newborns on days 2 and 3. RESULTS: At birth, Pref-1 levels were approximately 100-fold higher than in adults, being in SGA fetuses approximately 50% higher than in AGA fetuses. By age 4 months, Pref-1 had reached near-adult levels and the original AGA versus SGA difference had disappeared. Pref-1 levels were low in late-gestational women and were still elevated in newborns. CONCLUSIONS: Pref-1 is abundantly present in the fetus, is higher in SGA than in AGA fetuses, and is likely to be of fetal origin. We speculate that Pref-1 in early life contributes to variation in postnatal adipocyte numbers, in the subsequent expandability of adipose tissue, and thus in the susceptibility to diabetes in later life.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc11-1990</identifier><identifier>PMID: 22338099</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>adipocytes ; adipose tissue ; Adult ; adults ; Age Factors ; Biological and medical sciences ; Birth weight ; Birth Weight - physiology ; Diabetes ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Fat cells ; Female ; fetus ; Fetus - metabolism ; Follow-Up Studies ; Gestational Age ; Humans ; Infant ; Infant, Newborn - blood ; Infant, Small for Gestational Age - blood ; Infants ; Intercellular Signaling Peptides and Proteins - analysis ; Intercellular Signaling Peptides and Proteins - blood ; Intercellular Signaling Peptides and Proteins - metabolism ; Male ; Medical sciences ; Membrane proteins ; Membrane Proteins - analysis ; Membrane Proteins - blood ; Membrane Proteins - metabolism ; Metabolic diseases ; Metabolic disorders ; Miscellaneous ; neonates ; Newborn babies ; Nutrition research ; Original Research ; Physiological aspects ; Pregnancy ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; small for gestational age ; Studies ; women</subject><ispartof>Diabetes care, 2012-04, Vol.35 (4), p.848-849</ispartof><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 American Diabetes Association</rights><rights>Copyright American Diabetes Association Apr 2012</rights><rights>2012 by the American Diabetes Association. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-d7814efc134d03509f261bc2b6177819a8a98a5f550eb576f4f0f54e99485dfd3</citedby><cites>FETCH-LOGICAL-c560t-d7814efc134d03509f261bc2b6177819a8a98a5f550eb576f4f0f54e99485dfd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25654759$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22338099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Zegher, Francis</creatorcontrib><creatorcontrib>Díaz, Marta</creatorcontrib><creatorcontrib>Sebastiani, Giorgia</creatorcontrib><creatorcontrib>Martín-Ancel, Ana</creatorcontrib><creatorcontrib>Sánchez-Infantes, David</creatorcontrib><creatorcontrib>López-Bermejo, Abel</creatorcontrib><creatorcontrib>Ibáñez, Lourdes</creatorcontrib><title>Abundance of Circulating Preadipocyte Factor 1 in Early Life</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>OBJECTIVE: Soluble preadipocyte factor 1 (Pref-1) inhibits adipocyte differentiation. We tested whether circulating levels of soluble Pref-1 are higher in smaller fetuses. RESEARCH DESIGN AND METHODS: We performed longitudinal assessments of circulating Pref-1 in infants born appropriate for gestational age (AGA) or small for gestational age (SGA) and also in late-gestational women and in newborns on days 2 and 3. RESULTS: At birth, Pref-1 levels were approximately 100-fold higher than in adults, being in SGA fetuses approximately 50% higher than in AGA fetuses. By age 4 months, Pref-1 had reached near-adult levels and the original AGA versus SGA difference had disappeared. Pref-1 levels were low in late-gestational women and were still elevated in newborns. CONCLUSIONS: Pref-1 is abundantly present in the fetus, is higher in SGA than in AGA fetuses, and is likely to be of fetal origin. We speculate that Pref-1 in early life contributes to variation in postnatal adipocyte numbers, in the subsequent expandability of adipose tissue, and thus in the susceptibility to diabetes in later life.</description><subject>adipocytes</subject><subject>adipose tissue</subject><subject>Adult</subject><subject>adults</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Birth weight</subject><subject>Birth Weight - physiology</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Fat cells</subject><subject>Female</subject><subject>fetus</subject><subject>Fetus - metabolism</subject><subject>Follow-Up Studies</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn - blood</subject><subject>Infant, Small for Gestational Age - blood</subject><subject>Infants</subject><subject>Intercellular Signaling Peptides and Proteins - analysis</subject><subject>Intercellular Signaling Peptides and Proteins - blood</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane proteins</subject><subject>Membrane Proteins - analysis</subject><subject>Membrane Proteins - blood</subject><subject>Membrane Proteins - metabolism</subject><subject>Metabolic diseases</subject><subject>Metabolic disorders</subject><subject>Miscellaneous</subject><subject>neonates</subject><subject>Newborn babies</subject><subject>Nutrition research</subject><subject>Original Research</subject><subject>Physiological aspects</subject><subject>Pregnancy</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>small for gestational age</subject><subject>Studies</subject><subject>women</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptklGL1DAUhYMo7jj64B_Q4iLiQ9ekSdoEZGEYdlUYUNB9Dml6U7N0kjFphfn3ps64ujLkIZD73XNvDgeh5wRfVJQ27zpDSEmkxA_QgkjKS86ZeIgWmDBZcimrM_QkpVuMMWNCPEZnVW4TWMoFer9qJ99pb6AItli7aKZBj873xZcIunO7YPYjFNfajCEWpHC-uNJx2BcbZ-EpemT1kODZ8V6im-urb-uP5ebzh0_r1aY0vMZj2TWCMLCGUNZhyrG0VU1aU7U1aXJJaqGl0NxyjqHlTW2ZxZYzkJIJ3tmOLtHlQXc3tVvoDPgx6kHtotvquFdBO3W_4t131YefilIsKkmywJujQAw_Jkij2rpkYBi0hzAllQcJSUR2ZYle_Ufehin6_Dsla8qJqMksd36Aej2Act6GPNXMkmpV_SaElJkqT1A9eMgrBg_W5ed7_MUJPp8Ots6cbHh7aDAxpBTB3jlCsJqDoeZgqDkYmX3xr4V35J8kZOD1EdDJ6MHGnAmX_nK85qzhM_fywFkdlO5jZm6-VjlpGBPOMBX0F9WdxY4</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>de Zegher, Francis</creator><creator>Díaz, Marta</creator><creator>Sebastiani, Giorgia</creator><creator>Martín-Ancel, Ana</creator><creator>Sánchez-Infantes, David</creator><creator>López-Bermejo, Abel</creator><creator>Ibáñez, Lourdes</creator><general>American Diabetes Association</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120401</creationdate><title>Abundance of Circulating Preadipocyte Factor 1 in Early Life</title><author>de Zegher, Francis ; Díaz, Marta ; Sebastiani, Giorgia ; Martín-Ancel, Ana ; Sánchez-Infantes, David ; López-Bermejo, Abel ; Ibáñez, Lourdes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c560t-d7814efc134d03509f261bc2b6177819a8a98a5f550eb576f4f0f54e99485dfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>adipocytes</topic><topic>adipose tissue</topic><topic>Adult</topic><topic>adults</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Birth weight</topic><topic>Birth Weight - physiology</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Fat cells</topic><topic>Female</topic><topic>fetus</topic><topic>Fetus - metabolism</topic><topic>Follow-Up Studies</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn - blood</topic><topic>Infant, Small for Gestational Age - blood</topic><topic>Infants</topic><topic>Intercellular Signaling Peptides and Proteins - analysis</topic><topic>Intercellular Signaling Peptides and Proteins - blood</topic><topic>Intercellular Signaling Peptides and Proteins - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane proteins</topic><topic>Membrane Proteins - analysis</topic><topic>Membrane Proteins - blood</topic><topic>Membrane Proteins - metabolism</topic><topic>Metabolic diseases</topic><topic>Metabolic disorders</topic><topic>Miscellaneous</topic><topic>neonates</topic><topic>Newborn babies</topic><topic>Nutrition research</topic><topic>Original Research</topic><topic>Physiological aspects</topic><topic>Pregnancy</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>small for gestational age</topic><topic>Studies</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Zegher, Francis</creatorcontrib><creatorcontrib>Díaz, Marta</creatorcontrib><creatorcontrib>Sebastiani, Giorgia</creatorcontrib><creatorcontrib>Martín-Ancel, Ana</creatorcontrib><creatorcontrib>Sánchez-Infantes, David</creatorcontrib><creatorcontrib>López-Bermejo, Abel</creatorcontrib><creatorcontrib>Ibáñez, Lourdes</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Zegher, Francis</au><au>Díaz, Marta</au><au>Sebastiani, Giorgia</au><au>Martín-Ancel, Ana</au><au>Sánchez-Infantes, David</au><au>López-Bermejo, Abel</au><au>Ibáñez, Lourdes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abundance of Circulating Preadipocyte Factor 1 in Early Life</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>35</volume><issue>4</issue><spage>848</spage><epage>849</epage><pages>848-849</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>OBJECTIVE: Soluble preadipocyte factor 1 (Pref-1) inhibits adipocyte differentiation. We tested whether circulating levels of soluble Pref-1 are higher in smaller fetuses. RESEARCH DESIGN AND METHODS: We performed longitudinal assessments of circulating Pref-1 in infants born appropriate for gestational age (AGA) or small for gestational age (SGA) and also in late-gestational women and in newborns on days 2 and 3. RESULTS: At birth, Pref-1 levels were approximately 100-fold higher than in adults, being in SGA fetuses approximately 50% higher than in AGA fetuses. By age 4 months, Pref-1 had reached near-adult levels and the original AGA versus SGA difference had disappeared. Pref-1 levels were low in late-gestational women and were still elevated in newborns. CONCLUSIONS: Pref-1 is abundantly present in the fetus, is higher in SGA than in AGA fetuses, and is likely to be of fetal origin. We speculate that Pref-1 in early life contributes to variation in postnatal adipocyte numbers, in the subsequent expandability of adipose tissue, and thus in the susceptibility to diabetes in later life.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>22338099</pmid><doi>10.2337/dc11-1990</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes care, 2012-04, Vol.35 (4), p.848-849 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3308291 |
| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | adipocytes adipose tissue Adult adults Age Factors Biological and medical sciences Birth weight Birth Weight - physiology Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Fat cells Female fetus Fetus - metabolism Follow-Up Studies Gestational Age Humans Infant Infant, Newborn - blood Infant, Small for Gestational Age - blood Infants Intercellular Signaling Peptides and Proteins - analysis Intercellular Signaling Peptides and Proteins - blood Intercellular Signaling Peptides and Proteins - metabolism Male Medical sciences Membrane proteins Membrane Proteins - analysis Membrane Proteins - blood Membrane Proteins - metabolism Metabolic diseases Metabolic disorders Miscellaneous neonates Newborn babies Nutrition research Original Research Physiological aspects Pregnancy Public health. Hygiene Public health. Hygiene-occupational medicine small for gestational age Studies women |
| title | Abundance of Circulating Preadipocyte Factor 1 in Early Life |
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