Terminally differentiated astrocytes lack DNA damage response signaling and are radioresistant but retain DNA repair proficiency

The impact and consequences of damage generation into genomic DNA, especially in the form of DNA double-strand breaks, and of the DNA-damage response (DDR) pathways that are promptly activated, have been elucidated in great detail. Most of this research, however, has been performed on proliferating,...

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Veröffentlicht in:	Cell death and differentiation 2012-04, Vol.19 (4), p.582-591
Hauptverfasser:	Schneider, L, Fumagalli, M, d'Adda di Fagagna, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Astrocytes Astrocytes - cytology Astrocytes - metabolism Ataxia Telangiectasia Mutated Proteins Biochemistry Biomedical and Life Sciences Brain Brain research Cell Biology Cell cycle Cell Cycle Analysis Cell Cycle Proteins - biosynthesis Cell death Cell Differentiation Cell Line Cellular Biology DNA Breaks, Double-Stranded - radiation effects DNA damage DNA repair DNA Repair - physiology DNA Repair - radiation effects DNA-Activated Protein Kinase - metabolism DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - metabolism DNA-dependent protein kinase Gamma Rays - adverse effects genomics Ionizing radiation Kinases Life Sciences Mice Neural stem cells Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurons Neurons - cytology Neurons - metabolism Non-homologous end joining Nuclear Proteins - metabolism Oncology Original Paper Phosphatidylinositol 3-Kinases - metabolism Physiology Plasticity (developmental) Protein kinase Protein-Serine-Threonine Kinases - biosynthesis Proteins Radiation Radiation Tolerance - physiology Radiation Tolerance - radiation effects Radiosensitivity Signal transduction Signal Transduction - physiology Signal Transduction - radiation effects Stem Cells Transcription Transcription, Genetic - physiology Transcription, Genetic - radiation effects Tumor Suppressor Proteins - biosynthesis X-rays
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