p90RSK Targets the ERK5-CHIP Ubiquitin E3 Ligase Activity in Diabetic Hearts and Promotes Cardiac Apoptosis and Dysfunction

RATIONALE:Cardiomyocyte apoptosis is one of the key events in the development and progression of heart failure, and a crucial role for ICER (inducible cAMP early repressor) in this process has been previously reported. ERK5 is known to inhibit cardiac apoptosis after myocardial infarction (MI), espe...

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Veröffentlicht in:	Circulation research 2012-02, Vol.110 (4), p.536-550
Hauptverfasser:	Le, Nhat-Tu, Takei, Yuichiro, Shishido, Tetsuro, Woo, Chang-Hoon, Chang, Eugene, Heo, Kyung-Sun, Lee, Hakjoo, Lu, Yan, Morrell, Craig, Oikawa, Masayoshi, McClain, Carolyn, Wang, Xin, Tournier, Cathy, Molina, Carlos A, Taunton, Jack, Yan, Chen, Fujiwara, Keigi, Patterson, Cam, Yang, Jay, Abe, Jun-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Animals Animals, Newborn Apoptosis Binding Sites Binding, Competitive Biological and medical sciences Cardiology. Vascular system Cells, Cultured Coronary heart disease Cyclic AMP Response Element Modulator - metabolism Diabetes Mellitus, Experimental - enzymology Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme Activation Etiopathogenesis. Screening. Investigations. Target tissue resistance Fundamental and applied biological sciences. Psychology Heart MAP Kinase Kinase 5 - genetics MAP Kinase Kinase 5 - metabolism Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Mitogen-Activated Protein Kinase 7 - deficiency Mitogen-Activated Protein Kinase 7 - genetics Mitogen-Activated Protein Kinase 7 - metabolism Myocardial Infarction - enzymology Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocytes, Cardiac - enzymology Myocytes, Cardiac - pathology Rats Rats, Sprague-Dawley Ribosomal Protein S6 Kinases, 90-kDa - genetics Ribosomal Protein S6 Kinases, 90-kDa - metabolism Signal Transduction Time Factors Transfection Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Vertebrates: cardiovascular system
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