Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms

In most sexually reproducing animals, replication and maintenance of telomeres occurs in the germ line and during early development in embryogenesis through the use of telomerase. Somatic cells generally do not maintain telomere sequences, and these cells become senescent in adults as telomeres shor...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-03, Vol.109 (11), p.4209-4214
Hauptverfasser:	Tan, Thomas C. J, Rahman, Ruman, Jaber-Hijazi, Farah, Felix, Daniel A, Chen, Chen, Louis, Edward J, Aboobaker, Aziz
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptability Adaptations adults Alternative Splicing Alternative Splicing - genetics Amputation Animal reproduction Animal traps Animals Biological Sciences Cellular senescence Chromosomes Cloning cytology early development Embryogenesis Enzymes enzymology Evolution Gene Expression Regulation genetics Germ cells Germ Cells - metabolism growth & development In Situ Hybridization Irradiation Maintenance metabolism Molecular Sequence Data Planarians Planarians - enzymology Planarians - genetics Planarians - growth & development protein subunits Proteins Regeneration Regeneration - genetics Replication Reproduction Reproduction, Asexual Reproduction, Asexual - genetics RNA Interference RNA, Messenger RNA, Messenger - genetics RNA, Messenger - metabolism Sexual reproduction Somatic cells Stem cells Stem Cells - cytology Stem Cells - metabolism Structure-function relationships T tests Telomerase Telomerase - metabolism Telomere Telomere - metabolism Telomere Homeostasis Telomere Homeostasis - genetics Telomeres
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