Double-illumination photoacoustic microscopy
Recent developments of optical-resolution photoacoustic microscopy (OR-PAM) have improved its spatial resolution and imaging speed. However, the penetration depth of OR-PAM is still limited to ~1 mm in tissue, owing to the strong tissue scattering. Here, we have developed double-illumination PAM (DI...
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| Veröffentlicht in: | Optics letters 2012-02, Vol.37 (4), p.659-661 |
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| container_issue | 4 |
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| container_title | Optics letters |
| container_volume | 37 |
| creator | Yao, Junjie Maslov, Konstantin I Puckett, Ernest R Rowland, Kathryn J Warner, Brad W Wang, Lihong V |
| description | Recent developments of optical-resolution photoacoustic microscopy (OR-PAM) have improved its spatial resolution and imaging speed. However, the penetration depth of OR-PAM is still limited to ~1 mm in tissue, owing to the strong tissue scattering. Here, we have developed double-illumination PAM (DI-PAM), which illuminates the sample from both top and bottom sides simultaneously. Through phantom and in vivo experiments, we have demonstrated for thin targets that DI-PAM has a penetration depth of ~2 mm in tissue at 532 nm and a focal zone of 260 μm, both significant improvements over traditional reflection or transmission-mode OR-PAM. |
| doi_str_mv | 10.1364/OL.37.000659 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0146-9592 |
| ispartof | Optics letters, 2012-02, Vol.37 (4), p.659-661 |
| issn | 0146-9592 1539-4794 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3306616 |
| source | MEDLINE; Optica Publishing Group Journals |
| subjects | Animals Biocompatibility Biomedical materials Chickens Ear - anatomy & histology Humans In vivo testing In vivo tests Light Mice Mice, Inbred C57BL Microscopy, Acoustic - instrumentation Microscopy, Acoustic - methods Penetration depth Phantoms, Imaging Photoacoustic microscopy Reflection Surgical implants |
| title | Double-illumination photoacoustic microscopy |
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