Tissue engineering of functional articular cartilage: the current status

Osteoarthritis is a degenerative joint disease characterized by pain and disability. It involves all ages and 70% of people aged >65 have some degree of osteoarthritis. Natural cartilage repair is limited because chondrocyte density and metabolism are low and cartilage has no blood supply. The re...

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Veröffentlicht in:	Cell and tissue research 2012-03, Vol.347 (3), p.613-627
Hauptverfasser:	Kock, Linda, van Donkelaar, Corrinus C, Ito, Keita
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Arthritis autografting Autografts Biomechanical Phenomena Biomedical and Life Sciences Biomedicine Blood Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - cytology Cartilage, Articular - metabolism Cartilage, Articular - physiology Chondrocytes debridement DNA repair elderly Extracellular matrix Human Genetics Humans Joint diseases Joints Mechanical properties Mechanical stimuli Metabolism Molecular Medicine Osteoarthritis Pain perichondrium Physiological aspects Proteomics Review scaffolds Signal Transduction Tissue engineering Tissue Engineering - methods Tissue Engineering - trends Tissue Scaffolds
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