Tissue engineering of functional articular cartilage: the current status
Osteoarthritis is a degenerative joint disease characterized by pain and disability. It involves all ages and 70% of people aged >65 have some degree of osteoarthritis. Natural cartilage repair is limited because chondrocyte density and metabolism are low and cartilage has no blood supply. The re...
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| Veröffentlicht in: | Cell and tissue research 2012-03, Vol.347 (3), p.613-627 |
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| description | Osteoarthritis is a degenerative joint disease characterized by pain and disability. It involves all ages and 70% of people aged >65 have some degree of osteoarthritis. Natural cartilage repair is limited because chondrocyte density and metabolism are low and cartilage has no blood supply. The results of joint-preserving treatment protocols such as debridement, mosaicplasty, perichondrium transplantation and autologous chondrocyte implantation vary largely and the average long-term result is unsatisfactory. One reason for limited clinical success is that most treatments require new cartilage to be formed at the site of a defect. However, the mechanical conditions at such sites are unfavorable for repair of the original damaged cartilage. Therefore, it is unlikely that healthy cartilage would form at these locations. The most promising method to circumvent this problem is to engineer mechanically stable cartilage ex vivo and to implant that into the damaged tissue area. This review outlines the issues related to the composition and functionality of tissue-engineered cartilage. In particular, the focus will be on the parameters cell source, signaling molecules, scaffolds and mechanical stimulation. In addition, the current status of tissue engineering of cartilage will be discussed, with the focus on extracellular matrix content, structure and its functionality. |
| doi_str_mv | 10.1007/s00441-011-1243-1 |
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It involves all ages and 70% of people aged >65 have some degree of osteoarthritis. Natural cartilage repair is limited because chondrocyte density and metabolism are low and cartilage has no blood supply. The results of joint-preserving treatment protocols such as debridement, mosaicplasty, perichondrium transplantation and autologous chondrocyte implantation vary largely and the average long-term result is unsatisfactory. One reason for limited clinical success is that most treatments require new cartilage to be formed at the site of a defect. However, the mechanical conditions at such sites are unfavorable for repair of the original damaged cartilage. Therefore, it is unlikely that healthy cartilage would form at these locations. The most promising method to circumvent this problem is to engineer mechanically stable cartilage ex vivo and to implant that into the damaged tissue area. This review outlines the issues related to the composition and functionality of tissue-engineered cartilage. In particular, the focus will be on the parameters cell source, signaling molecules, scaffolds and mechanical stimulation. In addition, the current status of tissue engineering of cartilage will be discussed, with the focus on extracellular matrix content, structure and its functionality.</description><identifier>ISSN: 0302-766X</identifier><identifier>EISSN: 1432-0878</identifier><identifier>DOI: 10.1007/s00441-011-1243-1</identifier><identifier>PMID: 22030892</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Age ; Animals ; Arthritis ; autografting ; Autografts ; Biomechanical Phenomena ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Cartilage ; Cartilage (articular) ; Cartilage diseases ; Cartilage, Articular - cytology ; Cartilage, Articular - metabolism ; Cartilage, Articular - physiology ; Chondrocytes ; debridement ; DNA repair ; elderly ; Extracellular matrix ; Human Genetics ; Humans ; Joint diseases ; Joints ; Mechanical properties ; Mechanical stimuli ; Metabolism ; Molecular Medicine ; Osteoarthritis ; Pain ; perichondrium ; Physiological aspects ; Proteomics ; Review ; scaffolds ; Signal Transduction ; Tissue engineering ; Tissue Engineering - methods ; Tissue Engineering - trends ; Tissue Scaffolds</subject><ispartof>Cell and tissue research, 2012-03, Vol.347 (3), p.613-627</ispartof><rights>The Author(s) 2011</rights><rights>COPYRIGHT 2012 Springer</rights><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c689t-ed66f489da8077b0168aeba9f2d5532b964dfd6d23c636631614289fc38ee5d53</citedby><cites>FETCH-LOGICAL-c689t-ed66f489da8077b0168aeba9f2d5532b964dfd6d23c636631614289fc38ee5d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00441-011-1243-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00441-011-1243-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22030892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kock, Linda</creatorcontrib><creatorcontrib>van Donkelaar, Corrinus C</creatorcontrib><creatorcontrib>Ito, Keita</creatorcontrib><title>Tissue engineering of functional articular cartilage: the current status</title><title>Cell and tissue research</title><addtitle>Cell Tissue Res</addtitle><addtitle>Cell Tissue Res</addtitle><description>Osteoarthritis is a degenerative joint disease characterized by pain and disability. It involves all ages and 70% of people aged >65 have some degree of osteoarthritis. Natural cartilage repair is limited because chondrocyte density and metabolism are low and cartilage has no blood supply. The results of joint-preserving treatment protocols such as debridement, mosaicplasty, perichondrium transplantation and autologous chondrocyte implantation vary largely and the average long-term result is unsatisfactory. One reason for limited clinical success is that most treatments require new cartilage to be formed at the site of a defect. However, the mechanical conditions at such sites are unfavorable for repair of the original damaged cartilage. Therefore, it is unlikely that healthy cartilage would form at these locations. The most promising method to circumvent this problem is to engineer mechanically stable cartilage ex vivo and to implant that into the damaged tissue area. This review outlines the issues related to the composition and functionality of tissue-engineered cartilage. In particular, the focus will be on the parameters cell source, signaling molecules, scaffolds and mechanical stimulation. In addition, the current status of tissue engineering of cartilage will be discussed, with the focus on extracellular matrix content, structure and its functionality.</description><subject>Age</subject><subject>Animals</subject><subject>Arthritis</subject><subject>autografting</subject><subject>Autografts</subject><subject>Biomechanical Phenomena</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Cartilage</subject><subject>Cartilage (articular)</subject><subject>Cartilage diseases</subject><subject>Cartilage, Articular - cytology</subject><subject>Cartilage, Articular - metabolism</subject><subject>Cartilage, Articular - physiology</subject><subject>Chondrocytes</subject><subject>debridement</subject><subject>DNA repair</subject><subject>elderly</subject><subject>Extracellular matrix</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Joint diseases</subject><subject>Joints</subject><subject>Mechanical properties</subject><subject>Mechanical stimuli</subject><subject>Metabolism</subject><subject>Molecular Medicine</subject><subject>Osteoarthritis</subject><subject>Pain</subject><subject>perichondrium</subject><subject>Physiological aspects</subject><subject>Proteomics</subject><subject>Review</subject><subject>scaffolds</subject><subject>Signal Transduction</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - 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cytology</topic><topic>Cartilage, Articular - metabolism</topic><topic>Cartilage, Articular - physiology</topic><topic>Chondrocytes</topic><topic>debridement</topic><topic>DNA repair</topic><topic>elderly</topic><topic>Extracellular matrix</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Joint diseases</topic><topic>Joints</topic><topic>Mechanical properties</topic><topic>Mechanical stimuli</topic><topic>Metabolism</topic><topic>Molecular Medicine</topic><topic>Osteoarthritis</topic><topic>Pain</topic><topic>perichondrium</topic><topic>Physiological aspects</topic><topic>Proteomics</topic><topic>Review</topic><topic>scaffolds</topic><topic>Signal Transduction</topic><topic>Tissue engineering</topic><topic>Tissue Engineering - methods</topic><topic>Tissue Engineering - trends</topic><topic>Tissue Scaffolds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kock, Linda</creatorcontrib><creatorcontrib>van Donkelaar, Corrinus C</creatorcontrib><creatorcontrib>Ito, Keita</creatorcontrib><collection>AGRIS</collection><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell and tissue research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kock, Linda</au><au>van Donkelaar, Corrinus C</au><au>Ito, Keita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue engineering of functional articular cartilage: the current status</atitle><jtitle>Cell and tissue research</jtitle><stitle>Cell Tissue Res</stitle><addtitle>Cell Tissue Res</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>347</volume><issue>3</issue><spage>613</spage><epage>627</epage><pages>613-627</pages><issn>0302-766X</issn><eissn>1432-0878</eissn><abstract>Osteoarthritis is a degenerative joint disease characterized by pain and disability. It involves all ages and 70% of people aged >65 have some degree of osteoarthritis. Natural cartilage repair is limited because chondrocyte density and metabolism are low and cartilage has no blood supply. The results of joint-preserving treatment protocols such as debridement, mosaicplasty, perichondrium transplantation and autologous chondrocyte implantation vary largely and the average long-term result is unsatisfactory. One reason for limited clinical success is that most treatments require new cartilage to be formed at the site of a defect. However, the mechanical conditions at such sites are unfavorable for repair of the original damaged cartilage. Therefore, it is unlikely that healthy cartilage would form at these locations. The most promising method to circumvent this problem is to engineer mechanically stable cartilage ex vivo and to implant that into the damaged tissue area. This review outlines the issues related to the composition and functionality of tissue-engineered cartilage. In particular, the focus will be on the parameters cell source, signaling molecules, scaffolds and mechanical stimulation. In addition, the current status of tissue engineering of cartilage will be discussed, with the focus on extracellular matrix content, structure and its functionality.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22030892</pmid><doi>10.1007/s00441-011-1243-1</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell and tissue research, 2012-03, Vol.347 (3), p.613-627 |
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| subjects | Age Animals Arthritis autografting Autografts Biomechanical Phenomena Biomedical and Life Sciences Biomedicine Blood Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - cytology Cartilage, Articular - metabolism Cartilage, Articular - physiology Chondrocytes debridement DNA repair elderly Extracellular matrix Human Genetics Humans Joint diseases Joints Mechanical properties Mechanical stimuli Metabolism Molecular Medicine Osteoarthritis Pain perichondrium Physiological aspects Proteomics Review scaffolds Signal Transduction Tissue engineering Tissue Engineering - methods Tissue Engineering - trends Tissue Scaffolds |
| title | Tissue engineering of functional articular cartilage: the current status |
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