Mycophenolate mofetil but not atorvastatin attenuates atherosclerosis in lupus-prone LDLr−/− mice

Rationale Recent clinical and preclinical studies have demonstrated that systemic lupus erythematosus (SLE) is associated with an increased risk for cardiovascular disease (CVD). However, unlike in the general population, little is known regarding the efficacy of atheroprotective interventions in pa...

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Veröffentlicht in:	Annals of the rheumatic diseases 2012-03, Vol.71 (3), p.408-414
Hauptverfasser:	van Leuven, Sander I, Mendez-Fernandez, Yanice V, Wilhelm, Ashley J, Wade, Nekeithia S, Gabriel, Curtis L, Kastelein, John J, Stroes, Erik S, Tak, Paul P, Major, Amy S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Atherosclerosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - etiology Atherosclerosis - immunology Atherosclerosis - pathology Atherosclerosis - prevention & control Atorvastatin Calcium Biological and medical sciences Blood and lymphatic vessels Bone marrow Cardiology. Vascular system CD4-Positive T-Lymphocytes - drug effects Cholesterol Cholesterol - blood Cytokines Dermatology Disease Models, Animal Diseases of the osteoarticular system Drug Evaluation, Preclinical - methods Drug Therapy, Combination Female Genetic Predisposition to Disease Heptanoic Acids - therapeutic use Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Immunity, Cellular - drug effects Immunoglobulins Immunosuppressive Agents - therapeutic use Kidney diseases Laboratories Lipoproteins Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - immunology Lymphocytes Medical sciences Mice Mice, Inbred C57BL Mortality Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - therapeutic use Pathology Pyrroles - therapeutic use Rodents Skin involvement in other diseases. Miscellaneous. General aspects Software Studies
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