Uterine artery pulsatility index: a predictor of methotrexate resistance in gestational trophoblastic neoplasia

Background: Neo-angiogenesis is a hallmark of cancer. The aim of this study was to test the hypothesis, in a prospective patient cohort, that in low-risk gestational trophoblastic neoplasia (LR-GTN) the uterine artery pulsatility index (UAPI), a measure of tumour vascularity, can predict resistance...

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Veröffentlicht in:	British journal of cancer 2012-03, Vol.106 (6), p.1089-1094
Hauptverfasser:	Agarwal, R, Harding, V, Short, D, Fisher, R A, Sebire, N J, Harvey, R, Patel, D, Savage, P M, Lim, A K P, Seckl, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/67/1059/2326 692/699/67/1517 692/699/67/2328 Adult Angiogenesis Antimetabolites, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood Flow Velocity Cancer Cancer Research Chemotherapy Clinical Study Diseases of mother, fetus and pregnancy Drug Resistance Drug Resistance, Neoplasm Epidemiology Female Gestational Trophoblastic Disease - blood supply Gestational Trophoblastic Disease - drug therapy Gynecology. Andrology. Obstetrics Hospitals Humans Logistic Models Medical prognosis Medical research Medical sciences Metastasis Methotrexate - pharmacology Methotrexate - therapeutic use Molecular Medicine Multivariate Analysis Oncology Patients Pregnancy Pregnancy. Fetus. Placenta Pulsatile Flow Risk Factors Statistics, Nonparametric Surveillance Tumors Uterine Artery - physiopathology Veins & arteries
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