Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations

The epidermal growth factor receptor (EGFR) pathway is one of the most dysregulated molecular pathways in human cancers. Despite its well-established importance in tumor growth, progression and drug-resistant phenotype over the past several decades, targeted therapy designed to circumvent EGFR has y...

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Veröffentlicht in:	Cancer letters 2012-05, Vol.318 (2), p.124-134
Hauptverfasser:	Han, Woody, Lo, Hui-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autophagy Biology Cancer Cancer therapies Cell growth cell nucleus DNA repair drug resistance EGFR EGFRvIII Epidermal growth factor epidermal growth factor receptors Gene regulation Hematology, Oncology and Palliative Medicine HER2 Humans Kinases landscapes Ligands lung neoplasms Mutation Neoplasms - metabolism Neoplasms - pathology organelles patients phenotype Plasma prognosis Proliferation Radioresistance Receptor, Epidermal Growth Factor - metabolism Rodents Signal Transduction Subcellular Fractions - metabolism Survival therapeutics transcription (genetics) Tumorigenesis Tumors tyrosine
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