Toll-like receptors in chronic pain
Proinflammatory central immune signaling contributes significantly to the initiation and maintenance of heightened pain states. Recent discoveries have implicated the innate immune system, pattern recognition Toll-like receptors in triggering these proinflammatory central immune signaling events. Th...
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| Veröffentlicht in: | Experimental neurology 2012-04, Vol.234 (2), p.316-329 |
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| creator | Nicotra, Lauren Loram, Lisa C. Watkins, Linda R. Hutchinson, Mark R. |
| description | Proinflammatory central immune signaling contributes significantly to the initiation and maintenance of heightened pain states. Recent discoveries have implicated the innate immune system, pattern recognition Toll-like receptors in triggering these proinflammatory central immune signaling events. These exciting developments have been complemented by the discovery of neuronal expression of Toll-like receptors, suggesting pain pathways can be activated directly by the detection of pathogen associated molecular patterns or danger associated molecular patterns. This review will examine the evidence to date implicating Toll-like receptors and their associated signaling components in heightened pain states. In addition, insights into the impact Toll-like receptors have on priming central immune signaling systems for heightened pain states will be discussed. The influence possible sex differences in Toll-like receptor signaling have for female pain and the recognition of small molecule xenobiotics by Toll-like receptors will also be reviewed.
► Proinflammatory central immune signaling contributes to chronic pain. ► Toll-like receptors are now recognized to contribute to the chronic pain process. ► Recent evidence shows neuronal Toll-like receptor expression and activation. ► This review examines Toll-like receptors in chronic pain and xenobiotic recognition. |
| doi_str_mv | 10.1016/j.expneurol.2011.09.038 |
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► Proinflammatory central immune signaling contributes to chronic pain. ► Toll-like receptors are now recognized to contribute to the chronic pain process. ► Recent evidence shows neuronal Toll-like receptor expression and activation. ► This review examines Toll-like receptors in chronic pain and xenobiotic recognition.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/j.expneurol.2011.09.038</identifier><identifier>PMID: 22001158</identifier><identifier>CODEN: EXNEAC</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Chronic pain ; Chronic Pain - immunology ; Chronic Pain - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Glia ; Humans ; Immunity, Innate - physiology ; Male ; Medical sciences ; Neurology ; Nociception ; Nociception - physiology ; Proinflammatory ; Sex ; Sex Characteristics ; Signal Transduction - immunology ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Toll-like receptors ; Toll-Like Receptors - metabolism ; Vertebrates: nervous system and sense organs ; Xenobiotics</subject><ispartof>Experimental neurology, 2012-04, Vol.234 (2), p.316-329</ispartof><rights>2011</rights><rights>2015 INIST-CNRS</rights><rights>Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved.</rights><rights>Crown Copyright © 2011 Published by Elsevier Inc. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-1a7aa4211e273bf51e379f58c2a516df81fc19967474286c9f90305a6547c51e3</citedby><cites>FETCH-LOGICAL-c561t-1a7aa4211e273bf51e379f58c2a516df81fc19967474286c9f90305a6547c51e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.expneurol.2011.09.038$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25702850$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22001158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nicotra, Lauren</creatorcontrib><creatorcontrib>Loram, Lisa C.</creatorcontrib><creatorcontrib>Watkins, Linda R.</creatorcontrib><creatorcontrib>Hutchinson, Mark R.</creatorcontrib><title>Toll-like receptors in chronic pain</title><title>Experimental neurology</title><addtitle>Exp Neurol</addtitle><description>Proinflammatory central immune signaling contributes significantly to the initiation and maintenance of heightened pain states. Recent discoveries have implicated the innate immune system, pattern recognition Toll-like receptors in triggering these proinflammatory central immune signaling events. These exciting developments have been complemented by the discovery of neuronal expression of Toll-like receptors, suggesting pain pathways can be activated directly by the detection of pathogen associated molecular patterns or danger associated molecular patterns. This review will examine the evidence to date implicating Toll-like receptors and their associated signaling components in heightened pain states. In addition, insights into the impact Toll-like receptors have on priming central immune signaling systems for heightened pain states will be discussed. The influence possible sex differences in Toll-like receptor signaling have for female pain and the recognition of small molecule xenobiotics by Toll-like receptors will also be reviewed.
► Proinflammatory central immune signaling contributes to chronic pain. ► Toll-like receptors are now recognized to contribute to the chronic pain process. ► Recent evidence shows neuronal Toll-like receptor expression and activation. ► This review examines Toll-like receptors in chronic pain and xenobiotic recognition.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chronic pain</subject><subject>Chronic Pain - immunology</subject><subject>Chronic Pain - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glia</subject><subject>Humans</subject><subject>Immunity, Innate - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Nociception</subject><subject>Nociception - physiology</subject><subject>Proinflammatory</subject><subject>Sex</subject><subject>Sex Characteristics</subject><subject>Signal Transduction - immunology</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Toll-like receptors</subject><subject>Toll-Like Receptors - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Xenobiotics</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi1ERUPhL0AkhDjtdsZef12QqoqPSpV6KWfLdWapg7Ne7E1F_z0bJQQ49TSHeebVzDyMvUVoEVCdr1v6NQ60LTm1HBBbsC0I84wtECw0vBPwnC0AsGs6Y9Qpe1nrGgBsx_ULdsr53EJpFuzdbU6pSfEHLQsFGqdc6jIOy3Bf8hDDcvRxeMVOep8qvT7UM_bt86fby6_N9c2Xq8uL6yZIhVODXnvfcUTiWtz1Eklo20sTuJeoVr3BPqC1Sne640YF21sQIL2SnQ47-ox93OeO27sNrQINU_HJjSVufHl02Uf3f2eI9-57fnBCgLBCzgEfDgEl_9xSndwm1kAp-YHytjqrDCojlH2a5EZosHqXqfdkKLnWQv1xHwS3c-HW7ujC7Vw4sG52MU---fec49yf58_A-wPga_CpL34Isf7lpAZuJMzcxZ6j-fkPkYqrIdIQaBVnZ5Nb5fjkMr8B9oCq1w</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Nicotra, Lauren</creator><creator>Loram, Lisa C.</creator><creator>Watkins, Linda R.</creator><creator>Hutchinson, Mark R.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20120401</creationdate><title>Toll-like receptors in chronic pain</title><author>Nicotra, Lauren ; Loram, Lisa C. ; Watkins, Linda R. ; Hutchinson, Mark R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-1a7aa4211e273bf51e379f58c2a516df81fc19967474286c9f90305a6547c51e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chronic pain</topic><topic>Chronic Pain - immunology</topic><topic>Chronic Pain - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glia</topic><topic>Humans</topic><topic>Immunity, Innate - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Nociception</topic><topic>Nociception - physiology</topic><topic>Proinflammatory</topic><topic>Sex</topic><topic>Sex Characteristics</topic><topic>Signal Transduction - immunology</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Toll-like receptors</topic><topic>Toll-Like Receptors - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Xenobiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nicotra, Lauren</creatorcontrib><creatorcontrib>Loram, Lisa C.</creatorcontrib><creatorcontrib>Watkins, Linda R.</creatorcontrib><creatorcontrib>Hutchinson, Mark R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nicotra, Lauren</au><au>Loram, Lisa C.</au><au>Watkins, Linda R.</au><au>Hutchinson, Mark R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toll-like receptors in chronic pain</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>234</volume><issue>2</issue><spage>316</spage><epage>329</epage><pages>316-329</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>Proinflammatory central immune signaling contributes significantly to the initiation and maintenance of heightened pain states. Recent discoveries have implicated the innate immune system, pattern recognition Toll-like receptors in triggering these proinflammatory central immune signaling events. These exciting developments have been complemented by the discovery of neuronal expression of Toll-like receptors, suggesting pain pathways can be activated directly by the detection of pathogen associated molecular patterns or danger associated molecular patterns. This review will examine the evidence to date implicating Toll-like receptors and their associated signaling components in heightened pain states. In addition, insights into the impact Toll-like receptors have on priming central immune signaling systems for heightened pain states will be discussed. The influence possible sex differences in Toll-like receptor signaling have for female pain and the recognition of small molecule xenobiotics by Toll-like receptors will also be reviewed.
► Proinflammatory central immune signaling contributes to chronic pain. ► Toll-like receptors are now recognized to contribute to the chronic pain process. ► Recent evidence shows neuronal Toll-like receptor expression and activation. ► This review examines Toll-like receptors in chronic pain and xenobiotic recognition.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>22001158</pmid><doi>10.1016/j.expneurol.2011.09.038</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Chronic pain Chronic Pain - immunology Chronic Pain - metabolism Female Fundamental and applied biological sciences. Psychology Glia Humans Immunity, Innate - physiology Male Medical sciences Neurology Nociception Nociception - physiology Proinflammatory Sex Sex Characteristics Signal Transduction - immunology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Toll-like receptors Toll-Like Receptors - metabolism Vertebrates: nervous system and sense organs Xenobiotics |
| title | Toll-like receptors in chronic pain |
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