Maternal angiogenic profile in pregnancies that remain normotensive

Abstract Objective We sought to determine if maternal characteristics are associated with angiogenic profile in the first and second trimester of normotensive pregnancies. Study design Circulating levels of maternal placental like growth factor (PlGF), soluble fms-like tyrosine kinase receptor (sFlt...

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Veröffentlicht in:European journal of obstetrics & gynecology and reproductive biology 2011-10, Vol.158 (2), p.189-193
Hauptverfasser: Faupel-Badger, Jessica M, Staff, Anne Cathrine, Thadhani, Ravi, Powe, Camille E, Potischman, Nancy, Hoover, Robert N, Troisi, Rebecca
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container_issue 2
container_start_page 189
container_title European journal of obstetrics & gynecology and reproductive biology
container_volume 158
creator Faupel-Badger, Jessica M
Staff, Anne Cathrine
Thadhani, Ravi
Powe, Camille E
Potischman, Nancy
Hoover, Robert N
Troisi, Rebecca
description Abstract Objective We sought to determine if maternal characteristics are associated with angiogenic profile in the first and second trimester of normotensive pregnancies. Study design Circulating levels of maternal placental like growth factor (PlGF), soluble fms-like tyrosine kinase receptor (sFlt1), and soluble endoglin (sEng) were measured in serum samples collected during the first (median 11.3 weeks) and second trimester (median 17.1 weeks) of 182 normotensive pregnancies. Diastolic blood pressure (DBP), systolic blood pressure (SBP), and mean arterial pressure (MAP) were measured at the same visits when samples were collected to measure angiogenic factors. Linear regression analysis was used to examine associations of the angiogenic measures with maternal characteristics. The association between blood pressure measures and concentrations of angiogenic factors was evaluated using Spearman correlation and linear regression analysis. Results In adjusted analyses, nulliparous women had higher sFlt1 concentrations in both first ( p = 0.06) and second ( p = 0.001) trimester. Higher BMI was associated with greater sFlt1 concentrations in both the first ( p = 0.004) and second trimester ( p = 0.008), but significantly lower sEng concentrations in both trimesters ( p = 0.002 for first trimester and p = 0.0009 for second). Nulliparity and higher BMI also were associated with higher sFlt1/PLGF anti-angiogenic ratios in both first ( p = 0.05 and p = 0.007, respectively) and second trimesters ( p = 0.003 and p = 0.02, respectively). First trimester sFlt1 levels were weakly correlated with first trimester SBP ( rs = 0.18, p = 0.03) and MAP ( rs = 0.16, p = 0.04). Second trimester sEng levels were inversely associated with second trimester MAP ( rs = −0.17, p = 0.05). Including blood pressure measures in the linear regression models did not change the reported associations of angiogenic factors with maternal characteristics. Conclusions These results demonstrate that even early in normotensive pregnancies maternal characteristics are associated with variations in angiogenic profile across this population.
doi_str_mv 10.1016/j.ejogrb.2011.05.001
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Study design Circulating levels of maternal placental like growth factor (PlGF), soluble fms-like tyrosine kinase receptor (sFlt1), and soluble endoglin (sEng) were measured in serum samples collected during the first (median 11.3 weeks) and second trimester (median 17.1 weeks) of 182 normotensive pregnancies. Diastolic blood pressure (DBP), systolic blood pressure (SBP), and mean arterial pressure (MAP) were measured at the same visits when samples were collected to measure angiogenic factors. Linear regression analysis was used to examine associations of the angiogenic measures with maternal characteristics. The association between blood pressure measures and concentrations of angiogenic factors was evaluated using Spearman correlation and linear regression analysis. Results In adjusted analyses, nulliparous women had higher sFlt1 concentrations in both first ( p = 0.06) and second ( p = 0.001) trimester. Higher BMI was associated with greater sFlt1 concentrations in both the first ( p = 0.004) and second trimester ( p = 0.008), but significantly lower sEng concentrations in both trimesters ( p = 0.002 for first trimester and p = 0.0009 for second). Nulliparity and higher BMI also were associated with higher sFlt1/PLGF anti-angiogenic ratios in both first ( p = 0.05 and p = 0.007, respectively) and second trimesters ( p = 0.003 and p = 0.02, respectively). First trimester sFlt1 levels were weakly correlated with first trimester SBP ( rs = 0.18, p = 0.03) and MAP ( rs = 0.16, p = 0.04). Second trimester sEng levels were inversely associated with second trimester MAP ( rs = −0.17, p = 0.05). Including blood pressure measures in the linear regression models did not change the reported associations of angiogenic factors with maternal characteristics. Conclusions These results demonstrate that even early in normotensive pregnancies maternal characteristics are associated with variations in angiogenic profile across this population.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/j.ejogrb.2011.05.001</identifier><identifier>PMID: 21641103</identifier><identifier>CODEN: EOGRAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Angiogenesis Inducing Agents - blood ; Angiogenic factors ; Antigens, CD - blood ; Biological and medical sciences ; Biomarkers - blood ; Blood Pressure ; Endoglin ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Maternal ; Medical sciences ; Obstetrics and Gynecology ; Placenta Growth Factor ; PlGF ; Pregnancy ; Pregnancy - blood ; Pregnancy Proteins - blood ; Pregnancy Trimester, First - blood ; Pregnancy Trimester, First - physiology ; Pregnancy Trimester, Second - blood ; Pregnancy Trimester, Second - physiology ; Prospective Studies ; Receptors, Cell Surface - blood ; sFlt1 ; Soluble endoglin ; Vascular Endothelial Growth Factor Receptor-1 - blood</subject><ispartof>European journal of obstetrics &amp; gynecology and reproductive biology, 2011-10, Vol.158 (2), p.189-193</ispartof><rights>2011</rights><rights>2015 INIST-CNRS</rights><rights>Published by Elsevier Ireland Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-584678496b0407af13e16e11f9c238c88875d82e59226328a8fabc7327c323f83</citedby><cites>FETCH-LOGICAL-c547t-584678496b0407af13e16e11f9c238c88875d82e59226328a8fabc7327c323f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejogrb.2011.05.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=24604325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21641103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faupel-Badger, Jessica M</creatorcontrib><creatorcontrib>Staff, Anne Cathrine</creatorcontrib><creatorcontrib>Thadhani, Ravi</creatorcontrib><creatorcontrib>Powe, Camille E</creatorcontrib><creatorcontrib>Potischman, Nancy</creatorcontrib><creatorcontrib>Hoover, Robert N</creatorcontrib><creatorcontrib>Troisi, Rebecca</creatorcontrib><title>Maternal angiogenic profile in pregnancies that remain normotensive</title><title>European journal of obstetrics &amp; gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Abstract Objective We sought to determine if maternal characteristics are associated with angiogenic profile in the first and second trimester of normotensive pregnancies. Study design Circulating levels of maternal placental like growth factor (PlGF), soluble fms-like tyrosine kinase receptor (sFlt1), and soluble endoglin (sEng) were measured in serum samples collected during the first (median 11.3 weeks) and second trimester (median 17.1 weeks) of 182 normotensive pregnancies. Diastolic blood pressure (DBP), systolic blood pressure (SBP), and mean arterial pressure (MAP) were measured at the same visits when samples were collected to measure angiogenic factors. Linear regression analysis was used to examine associations of the angiogenic measures with maternal characteristics. The association between blood pressure measures and concentrations of angiogenic factors was evaluated using Spearman correlation and linear regression analysis. Results In adjusted analyses, nulliparous women had higher sFlt1 concentrations in both first ( p = 0.06) and second ( p = 0.001) trimester. Higher BMI was associated with greater sFlt1 concentrations in both the first ( p = 0.004) and second trimester ( p = 0.008), but significantly lower sEng concentrations in both trimesters ( p = 0.002 for first trimester and p = 0.0009 for second). Nulliparity and higher BMI also were associated with higher sFlt1/PLGF anti-angiogenic ratios in both first ( p = 0.05 and p = 0.007, respectively) and second trimesters ( p = 0.003 and p = 0.02, respectively). First trimester sFlt1 levels were weakly correlated with first trimester SBP ( rs = 0.18, p = 0.03) and MAP ( rs = 0.16, p = 0.04). Second trimester sEng levels were inversely associated with second trimester MAP ( rs = −0.17, p = 0.05). Including blood pressure measures in the linear regression models did not change the reported associations of angiogenic factors with maternal characteristics. 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Obstetrics</subject><subject>Humans</subject><subject>Maternal</subject><subject>Medical sciences</subject><subject>Obstetrics and Gynecology</subject><subject>Placenta Growth Factor</subject><subject>PlGF</subject><subject>Pregnancy</subject><subject>Pregnancy - blood</subject><subject>Pregnancy Proteins - blood</subject><subject>Pregnancy Trimester, First - blood</subject><subject>Pregnancy Trimester, First - physiology</subject><subject>Pregnancy Trimester, Second - blood</subject><subject>Pregnancy Trimester, Second - physiology</subject><subject>Prospective Studies</subject><subject>Receptors, Cell Surface - blood</subject><subject>sFlt1</subject><subject>Soluble endoglin</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - blood</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2P0zAQhi0EYrsL_wChXBCnFI8df-SChCpgkRZxAM6W606yDold7LTS_nsctewCF3yxZb_zzviZIeQF0DVQkG-GNQ6xT9s1owBrKtaUwiOyAq1YraRoHpMV5RRqBiAuyGXOAy2L8_YpuWAgGwDKV2Tz2c6Ygh0rG3ofewzeVfsUOz9i5UM5Yh9scB5zNd_auUo42XIfYprijCH7Iz4jTzo7Znx-3q_I9w_vv22u65svHz9t3t3UTjRqroVupNJNK7e0ocp2wBEkAnStY1w7rbUSO81QtIxJzrTVnd06xZlynPFO8yvy9uS7P2wn3DkMc7Kj2Sc_2XRnovXm75fgb00fj4ZzyoSGYvD6bJDizwPm2Uw-OxxHGzAestGtZJRJpoqyOSldijkn7O6zADULfjOYE36z4DdUmIK_hL38s8L7oN-8i-DVWWCzs2OXFrT5QddI2nAmHr6KhefRYzK5tCA43PmEbja76P9Xyb8GbvSlt3b8gXeYh3hYmp4NmMwMNV-XUVkmpVRZCCjOfwHEF7nR</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Faupel-Badger, Jessica M</creator><creator>Staff, Anne Cathrine</creator><creator>Thadhani, Ravi</creator><creator>Powe, Camille E</creator><creator>Potischman, Nancy</creator><creator>Hoover, Robert N</creator><creator>Troisi, Rebecca</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111001</creationdate><title>Maternal angiogenic profile in pregnancies that remain normotensive</title><author>Faupel-Badger, Jessica M ; Staff, Anne Cathrine ; Thadhani, Ravi ; Powe, Camille E ; Potischman, Nancy ; Hoover, Robert N ; Troisi, Rebecca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-584678496b0407af13e16e11f9c238c88875d82e59226328a8fabc7327c323f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Angiogenesis Inducing Agents - blood</topic><topic>Angiogenic factors</topic><topic>Antigens, CD - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood Pressure</topic><topic>Endoglin</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Maternal</topic><topic>Medical sciences</topic><topic>Obstetrics and Gynecology</topic><topic>Placenta Growth Factor</topic><topic>PlGF</topic><topic>Pregnancy</topic><topic>Pregnancy - blood</topic><topic>Pregnancy Proteins - blood</topic><topic>Pregnancy Trimester, First - blood</topic><topic>Pregnancy Trimester, First - physiology</topic><topic>Pregnancy Trimester, Second - blood</topic><topic>Pregnancy Trimester, Second - physiology</topic><topic>Prospective Studies</topic><topic>Receptors, Cell Surface - blood</topic><topic>sFlt1</topic><topic>Soluble endoglin</topic><topic>Vascular Endothelial Growth Factor Receptor-1 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faupel-Badger, Jessica M</creatorcontrib><creatorcontrib>Staff, Anne Cathrine</creatorcontrib><creatorcontrib>Thadhani, Ravi</creatorcontrib><creatorcontrib>Powe, Camille E</creatorcontrib><creatorcontrib>Potischman, Nancy</creatorcontrib><creatorcontrib>Hoover, Robert N</creatorcontrib><creatorcontrib>Troisi, Rebecca</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of obstetrics &amp; gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faupel-Badger, Jessica M</au><au>Staff, Anne Cathrine</au><au>Thadhani, Ravi</au><au>Powe, Camille E</au><au>Potischman, Nancy</au><au>Hoover, Robert N</au><au>Troisi, Rebecca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal angiogenic profile in pregnancies that remain normotensive</atitle><jtitle>European journal of obstetrics &amp; gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>158</volume><issue>2</issue><spage>189</spage><epage>193</epage><pages>189-193</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><coden>EOGRAL</coden><abstract>Abstract Objective We sought to determine if maternal characteristics are associated with angiogenic profile in the first and second trimester of normotensive pregnancies. Study design Circulating levels of maternal placental like growth factor (PlGF), soluble fms-like tyrosine kinase receptor (sFlt1), and soluble endoglin (sEng) were measured in serum samples collected during the first (median 11.3 weeks) and second trimester (median 17.1 weeks) of 182 normotensive pregnancies. Diastolic blood pressure (DBP), systolic blood pressure (SBP), and mean arterial pressure (MAP) were measured at the same visits when samples were collected to measure angiogenic factors. Linear regression analysis was used to examine associations of the angiogenic measures with maternal characteristics. The association between blood pressure measures and concentrations of angiogenic factors was evaluated using Spearman correlation and linear regression analysis. Results In adjusted analyses, nulliparous women had higher sFlt1 concentrations in both first ( p = 0.06) and second ( p = 0.001) trimester. Higher BMI was associated with greater sFlt1 concentrations in both the first ( p = 0.004) and second trimester ( p = 0.008), but significantly lower sEng concentrations in both trimesters ( p = 0.002 for first trimester and p = 0.0009 for second). Nulliparity and higher BMI also were associated with higher sFlt1/PLGF anti-angiogenic ratios in both first ( p = 0.05 and p = 0.007, respectively) and second trimesters ( p = 0.003 and p = 0.02, respectively). First trimester sFlt1 levels were weakly correlated with first trimester SBP ( rs = 0.18, p = 0.03) and MAP ( rs = 0.16, p = 0.04). Second trimester sEng levels were inversely associated with second trimester MAP ( rs = −0.17, p = 0.05). Including blood pressure measures in the linear regression models did not change the reported associations of angiogenic factors with maternal characteristics. Conclusions These results demonstrate that even early in normotensive pregnancies maternal characteristics are associated with variations in angiogenic profile across this population.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>21641103</pmid><doi>10.1016/j.ejogrb.2011.05.001</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Angiogenesis Inducing Agents - blood
Angiogenic factors
Antigens, CD - blood
Biological and medical sciences
Biomarkers - blood
Blood Pressure
Endoglin
Female
Gynecology. Andrology. Obstetrics
Humans
Maternal
Medical sciences
Obstetrics and Gynecology
Placenta Growth Factor
PlGF
Pregnancy
Pregnancy - blood
Pregnancy Proteins - blood
Pregnancy Trimester, First - blood
Pregnancy Trimester, First - physiology
Pregnancy Trimester, Second - blood
Pregnancy Trimester, Second - physiology
Prospective Studies
Receptors, Cell Surface - blood
sFlt1
Soluble endoglin
Vascular Endothelial Growth Factor Receptor-1 - blood
title Maternal angiogenic profile in pregnancies that remain normotensive
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