Cdc6-Induced Conformational Changes in ORC Bound to Origin DNA Revealed by Cryo-Electron Microscopy

The eukaryotic origin recognition complex (ORC) interacts with and remodels origins of DNA replication prior to initiation in S phase. Here, we report a single-particle cryo-EM-derived structure of the supramolecular assembly comprising Saccharomyces cerevisiae ORC, the replication initiation factor...

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Veröffentlicht in:	Structure (London) 2012-03, Vol.20 (3), p.534-544
Hauptverfasser:	Sun, Jingchuan, Kawakami, Hironori, Zech, Juergen, Speck, Christian, Stillman, Bruce, Li, Huilin
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Assembly BASIC BIOLOGICAL SCIENCES Bends Binding Cell Cycle Proteins - chemistry CONFORMATIONAL CHANGES Cryoelectron Microscopy CRYSTAL STRUCTURE Deoxyribonucleic acid DNA DNA REPLICATION DNA-Binding Proteins - chemistry MICROSCOPY Models, Molecular ORIGIN Origin Recognition Complex - chemistry Origins Protein Conformation Protein Subunits - chemistry PROTEINS Replication SACCHAROMYCES CEREVISIAE Saccharomyces cerevisiae Proteins - chemistry Three dimensional Transcription Factors - chemistry
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